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Review ArticleInvited Review

High-Flow Nasal Cannula Oxygen Therapy in Adults: Physiological Benefits, Indication, Clinical Benefits, and Adverse Effects

Masaji Nishimura
Respiratory Care April 2016, 61 (4) 529-541; DOI: https://doi.org/10.4187/respcare.04577
Masaji Nishimura
Department of Emergency and Critical Care Medicine, Tokushima University Graduate School, Kuramoto, Tokushima, Japan.
MD PhD
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References

  1. 1.↵
    1. Rouadi P,
    2. Baroody FM,
    3. Abbott D,
    4. Naureckas E,
    5. Solway J,
    6. Naclerio RM
    . A technique to measure the ability of the human nose to warm and humidify air. J Appl Physiol 1999;87(1):400–406.
    OpenUrlAbstract/FREE Full Text
  2. 2.↵
    1. Chanques G,
    2. Constantin JM,
    3. Sauter M,
    4. Jung B,
    5. Sebbane M,
    6. Verzilli D,
    7. et al
    . Discomfort associated with underhumidified high-flow oxygen therapy in critically ill patients. Intensive Care Med 2009;35(6):996–1003.
    OpenUrlCrossRefPubMedWeb of Science
  3. 3.↵
    1. Fontanari P,
    2. Burnet H,
    3. Zattara-Hartmann MC,
    4. Jammes Y
    . Changes in airway resistance induced by nasal inhalation of cold dry, dry, or moist air in normal individuals. J Appl Physiol 1996;81(4):1739–1743.
    OpenUrlAbstract/FREE Full Text
  4. 4.↵
    1. Fontanari P,
    2. Zattara-Hartmann MC,
    3. Burnet H,
    4. Jammes Y
    . Nasal eupnoeic inhalation of cold, dry air increases airway resistance in asthmatic patients. Eur Respir J 1997;10(10):2250–2254.
    OpenUrlAbstract
  5. 5.↵
    1. Salah B,
    2. Dinh Xuan AT,
    3. Fouilladieu JL,
    4. Lockhart A,
    5. Regnard J
    . Nasal mucociliary transport in healthy subjects is slower when breathing dry air. Eur Respir J 1988;1(9):852–855.
    OpenUrlAbstract/FREE Full Text
  6. 6.↵
    1. L'Her E,
    2. Deye N,
    3. Lellouche F,
    4. Taille S,
    5. Demoule A,
    6. Fraticelli A,
    7. et al
    . Physiologic effects of noninvasive ventilation during acute lung injury. Am J Respir Crit Care Med 2005;172(9):1112–1118.
    OpenUrlCrossRefPubMedWeb of Science
  7. 7.↵
    1. Markovitz GH,
    2. Colthurst J,
    3. Storer TW,
    4. Cooper CB
    . Effective inspired oxygen concentration measured via transtracheal and oral gas analysis. Respir Care 2010;55(4):453–459.
    OpenUrlAbstract/FREE Full Text
  8. 8.↵
    1. Bazuaye EA,
    2. Stone TN,
    3. Corris PA,
    4. Gibson GJ
    . Variability of inspired oxygen concentration with nasal cannulas. Thorax 1992;47(8):609–611.
    OpenUrlAbstract/FREE Full Text
  9. 9.↵
    1. Nishimura M
    . High-flow nasal cannula oxygen therapy in adults. J Intensive Care 2015;3(1):15.
    OpenUrlCrossRefPubMed
  10. 10.↵
    1. Frat JP,
    2. Thille AW,
    3. Mercat A,
    4. Girault C,
    5. Ragot S,
    6. Perbet S,
    7. et al
    . High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 2015;372(23):2185–2196.
    OpenUrlCrossRefPubMed
  11. 11.↵
    1. Stéphan F,
    2. Barrucand B,
    3. Petit P,
    4. Rézaiguia-Delclaux S,
    5. Médard A,
    6. Delannoy B,
    7. et al
    . High-flow nasal oxygen vs noninvasive positive airway pressure in hypoxemic patients after cardiothoracic surgery: A randomized clinical trial. JAMA 2015;313(23):2331–2339.
    OpenUrlPubMed
  12. 12.↵
    1. Parke RL,
    2. McGuinness SP
    . Pressures delivered by nasal high flow oxygen during all phases of the respiratory cycle. Respir Care 2013;58(10):1621–1624.
    OpenUrlAbstract/FREE Full Text
  13. 13.↵
    1. Girou E,
    2. Brun-Buisson C,
    3. Taillé S,
    4. Lemaire F,
    5. Brochard L
    . Secular trends in nosocomial infections and mortality associated with noninvasive ventilation in patients with exacerbation of COPD and pulmonary edema. JAMA 2003;290(22):2985–2991.
    OpenUrlCrossRefPubMedWeb of Science
  14. 14.↵
    1. Nava S,
    2. Cirio S,
    3. Fanfulla F,
    4. Carlucci A,
    5. Navarra A,
    6. Negri A,
    7. Ceriana P
    . Comparison of two humidification systems for long-term noninvasive mechanical ventilation. Eur Respir J 2008;32(2):460–464.
    OpenUrlAbstract/FREE Full Text
  15. 15.↵
    1. Nagata K,
    2. Morimoto T,
    3. Fujimoto D,
    4. Otoshi T,
    5. Nakagawa A,
    6. Otsuka K,
    7. et al
    . Efficacy of high-flow nasal cannula therapy in acute hypoxemic respiratory failure: decreased use of mechanical ventilation. Respir Care 2015;60(10):1390–1396.
    OpenUrlAbstract/FREE Full Text
  16. 16.↵
    1. Hirsch JA,
    2. Tokayer JL,
    3. Robinson MJ,
    4. Sackner MA
    . Effects of dry air and subsequent humidification on tracheal mucous velocity in dogs. J Appl Physiol 1975;39(2):242–246.
    OpenUrlAbstract/FREE Full Text
  17. 17.↵
    1. Chidekel A,
    2. Zhu Y,
    3. Wang J,
    4. Mosko JJ,
    5. Rodriguez E,
    6. Shaffer TH
    . The effects of gas humidification with high-flow nasal cannula on cultured human airway epithelial cells. Pulm Med 2012;2012:380686.
    OpenUrlPubMed
  18. 18.↵
    1. Barbet JP,
    2. Chauveau M,
    3. Labbé S,
    4. Lockhart A
    . Breathing dry air causes acute epithelial damage and inflammation of the guinea pig trachea. J Appl Physiol 1988;64(5):1851–1857.
    OpenUrlAbstract/FREE Full Text
  19. 19.↵
    1. Berk JL,
    2. Lenner KA,
    3. McFadden ER Jr.
    . Cold-induced bronchoconstriction: role of cutaneous reflexes vs. direct airway effects. J Appl Physiol 1987;63(2):659–664.
    OpenUrlAbstract/FREE Full Text
  20. 20.↵
    1. Van Oostdam JC,
    2. Walker DC,
    3. Knudson K,
    4. Dirks P,
    5. Dahlby RW,
    6. Hogg JC
    . Effect of breathing dry air on structure and function of airways. J Appl Physiol 1986;61(1):312–317.
    OpenUrlAbstract/FREE Full Text
  21. 21.↵
    1. Campbell EJ,
    2. Baker MD,
    3. Crites-Silver P
    . Subjective effects of humidification of oxygen for delivery by nasal cannula: a prospective study. Chest 1988;93(2):289–293.
    OpenUrlCrossRefPubMedWeb of Science
  22. 22.↵
    1. Carratalá Perales JM,
    2. Llorens P,
    3. Brouzet B,
    4. Albert Jiménez AR,
    5. Fernández-Cañadas JM,
    6. Carbajosa Dalmau J,
    7. et al
    . High-flow therapy via nasal cannula in acute heart failure. Rev Esp Cardiol 2011;64(8):723–725.
    OpenUrlPubMed
  23. 23.↵
    1. Koutsourelakis I,
    2. Vagiakis E,
    3. Perraki E,
    4. Karatza M,
    5. Magkou C,
    6. Kopaka M,
    7. et al
    . Nasal inflammation in sleep apnoea patients using CPAP and effect of heated humidification. Eur Respir J 2011;37(3):587–594.
    OpenUrlAbstract/FREE Full Text
  24. 24.↵
    1. Oto J,
    2. Imanaka H,
    3. Nishimura M
    . Clinical factors affecting inspired gas humidification and oral dryness during noninvasive ventilation. J Crit Care 2011;26(5):535.e9–535.e15.
    OpenUrlPubMed
  25. 25.↵
    1. Wood KE,
    2. Flaten AL,
    3. Backes WJ
    . Inspissated secretions: a life-threatening complication of prolonged noninvasive ventilation. Respir Care 2000;45(5):491–493.
    OpenUrlPubMed
  26. 26.↵
    1. Doyle A,
    2. Joshi M,
    3. Frank P,
    4. Craven T,
    5. Moondi P,
    6. Young P
    . A change in humidification system can eliminate endotracheal tube occlusion. J Crit Care 2011;26(6):637.e1–e4.
    OpenUrlPubMed
  27. 27.↵
    1. Greenspan JS,
    2. Wolfson MR,
    3. Shaffer TH
    . Airway responsiveness to low inspired gas temperature in preterm neonates. J Pediatr 1991;118(3):443–445.
    OpenUrlCrossRefPubMedWeb of Science
  28. 28.↵
    1. Rea H,
    2. McAuley S,
    3. Jayaram L,
    4. Garrett J,
    5. Hockey H,
    6. Storey L,
    7. et al
    . The clinical utility of long-term humidification therapy in chronic airway disease. Respir Med 2010;104(4):525–533.
    OpenUrlCrossRefPubMed
  29. 29.↵
    1. Tobin MJ,
    2. Mador MJ,
    3. Guenther SM,
    4. Lodato RF,
    5. Sackner MA
    . Variability of resting respiratory drive and timing in healthy subjects. J Appl Physiol 1988;65(1):309–317.
    OpenUrlAbstract/FREE Full Text
  30. 30.↵
    1. Chikata Y,
    2. Izawa M,
    3. Okuda N,
    4. Itagaki T,
    5. Nakataki E,
    6. Onodera M,
    7. et al
    . Humidification performance of two high-flow nasal cannula devices: a bench study. Respir Care 2014;59(8):1186–1190.
    OpenUrlAbstract/FREE Full Text
  31. 31.↵
    1. Chikata Y,
    2. Unai K,
    3. Izawa M,
    4. Okuda N,
    5. Oto J,
    6. Nishimura M
    . Condensation in the tube during high-flow nasal cannula therapy: a bench study. Respir Care 2016;61(3):300–305.
    OpenUrlAbstract/FREE Full Text
  32. 32.↵
    1. Navalesi P,
    2. Fanfulla F,
    3. Frigerio P,
    4. Gregoretti C,
    5. Nava S
    . Physiologic evaluation of noninvasive mechanical ventilation delivered with three types of masks in patients with chronic hypercapnic respiratory failure. Crit Care Med 2000;28(6):1785–1790.
    OpenUrlCrossRefPubMedWeb of Science
  33. 33.↵
    1. Conti G,
    2. Antonelli M,
    3. Navalesi P,
    4. Rocco M,
    5. Bufi M,
    6. Spadetta G,
    7. Meduri GU
    . Noninvasive vs. conventional mechanical ventilation in patients with chronic obstructive pulmonary disease after failure of medical treatment in the ward: a randomized trial. Intensive Care Med 2002;28(12):1701–1707.
    OpenUrlCrossRefPubMedWeb of Science
  34. 34.↵
    1. Gregoretti C,
    2. Confalonieri M,
    3. Navalesi P,
    4. Squadrone V,
    5. Frigerio P,
    6. Beltrame F,
    7. et al
    . Evaluation of patient skin breakdown and comfort with a new face mask for non-invasive ventilation: a multi-center study. Intensive Care Med 2002;28(3):278–284.
    OpenUrlCrossRefPubMedWeb of Science
  35. 35.↵
    1. Collins CL,
    2. Barfield C,
    3. Horne RS,
    4. Davis PG
    . A comparison of nasal trauma in preterm infants extubated to either heated humidified high-flow nasal cannulae or nasal continuous positive airway pressure. Eur J Pediatr 2014;173(2):181–186.
    OpenUrlCrossRefPubMed
  36. 36.↵
    1. Schwabbauer N,
    2. Berg B,
    3. Blumenstock G,
    4. Haap M,
    5. Hetzel J,
    6. Riessen R
    . Nasal high-flow oxygen therapy in patients with hypoxic respiratory failure: effect on functional and subjective respiratory parameters compared to conventional oxygen therapy and non-invasive ventilation (NIV). BMC Anesthesiol 2014;14:66.
    OpenUrlPubMed
  37. 37.↵
    1. Peters SG,
    2. Holets SR,
    3. Gay PC
    . High-flow nasal cannula therapy in do-not-intubate patients with hypoxemic respiratory distress. Respir Care 2013;58(4):597–600.
    OpenUrlAbstract/FREE Full Text
  38. 38.↵
    1. Itagaki T,
    2. Okuda N,
    3. Tsunano Y,
    4. Kohata H,
    5. Nakataki E,
    6. Onodera M,
    7. et al
    . Effect of high-flow nasal cannula on thoraco-abdominal synchrony in adult critically ill patients. Respir Care 2014;59(1):70–74.
    OpenUrlAbstract/FREE Full Text
  39. 39.↵
    1. Sztrymf B,
    2. Messika J,
    3. Bertrand F,
    4. Hurel D,
    5. Leon R,
    6. Dreyfuss D,
    7. Ricard JD
    . Beneficial effects of humidified high flow nasal oxygen in critical care patients: a prospective pilot study. Intensive Care Med 2011;37(11):1780–1786.
    OpenUrlCrossRefPubMedWeb of Science
  40. 40.↵
    1. Sztrymf B,
    2. Messika J,
    3. Mayot T,
    4. Lenglet H,
    5. Dreyfuss D,
    6. Ricard JD
    . Impact of high-flow nasal cannula oxygen therapy on intensive care unit patients with acute respiratory failure: a prospective observational study. J Crit Care 2012;27(3):324.e9–13.
    OpenUrlCrossRefPubMed
  41. 41.
    1. Roca O,
    2. Riera J,
    3. Torres F,
    4. Masclans JR
    . High-flow oxygen therapy in acute respiratory failure. Respir Care 2010;55(4):408–413.
    OpenUrlAbstract/FREE Full Text
  42. 42.↵
    1. Corley A,
    2. Caruana LR,
    3. Barnett AG,
    4. Tronstad O,
    5. Fraser JF
    . Oxygen delivery through high-flow nasal cannulae increase end-expiratory lung volume and reduce respiratory rate in post-cardiac surgical patients. Br J Anaesth 2011;107(6):998–1004.
    OpenUrlAbstract/FREE Full Text
  43. 43.↵
    1. Frizzola M,
    2. Miller TL,
    3. Rodriguez ME,
    4. Zhu Y,
    5. Rojas J,
    6. Hesek A,
    7. et al
    . High-flow nasal cannula: impact on oxygenation and ventilation in an acute lung injury model. Pediatr Pulmonol 2011;46(1):67–74.
    OpenUrlCrossRefPubMed
  44. 44.↵
    1. Lavizzari A,
    2. Veneroni C,
    3. Colnaghi M,
    4. Ciuffini F,
    5. Zannin E,
    6. Fumagalli M,
    7. et al
    . Respiratory mechanics during NCPAP and HHHFNC at equal distending pressures. Arch Dis Child Fetal Neonatal Ed 2014;99(4):F315–F320.
    OpenUrlAbstract/FREE Full Text
  45. 45.↵
    1. Saslow JG,
    2. Aghai ZH,
    3. Nakhla TA,
    4. Hart JJ,
    5. Lawrysh R,
    6. Stahl GE,
    7. Pyon KH
    . Work of breathing using high-flow nasal cannula in preterm infants. J Perinatol 2006;26(8):476–480.
    OpenUrlCrossRefPubMedWeb of Science
  46. 46.↵
    1. de Jongh BE,
    2. Locke R,
    3. Mackley A,
    4. Emberger J,
    5. Bostick D,
    6. Stefano J,
    7. et al
    . Work of breathing indices in infants with respiratory insufficiency receiving high-flow nasal cannula and nasal continuous positive airway pressure. J Perinatol 2014;34(1):27–32.
    OpenUrlCrossRefPubMed
  47. 47.↵
    1. Pham TM,
    2. O'Malley L,
    3. Mayfield S,
    4. Martin S,
    5. Schibler A
    . The effect of high flow nasal cannula therapy on the work of breathing in infants with bronchiolitis. Pediatr Pulmonol 2015;50(7):713–720.
    OpenUrlPubMed
  48. 48.↵
    1. Benchetrit G
    . Breathing pattern in humans: diversity and individuality. Respir Physiol 2000;122(2):123–129.
    OpenUrlCrossRefPubMed
  49. 49.↵
    1. Ritchie JE,
    2. Williams AB,
    3. Gerard C,
    4. Hockey H
    . Evaluation of a humidified nasal high-flow oxygen system, using oxygraphy, capnography and measurement of upper airway pressures. Anaesth Intensive Care 2011;39(6):1103–1110.
    OpenUrlPubMedWeb of Science
  50. 50.↵
    1. Wettstein RB,
    2. Shelledy DC,
    3. Peters JI
    . Delivered oxygen concentrations using low-flow and high-flow nasal cannulas. Respir Care 2005;50(5):604–609.
    OpenUrlAbstract/FREE Full Text
  51. 51.↵
    1. Lampland AL,
    2. Plumm B,
    3. Meyers PA,
    4. Worwa CT,
    5. Mammel MC
    . Observational study of humidified high-flow nasal cannula compared with nasal continuous positive airway pressure. J Pediatr 2009;154(2):177–182.
    OpenUrlCrossRefPubMedWeb of Science
  52. 52.↵
    1. Parke R,
    2. McGuinness S,
    3. Eccleston M
    . Nasal high-flow therapy delivers low level positive airway pressure. Br J Anaesth 2009;103(6):886–890.
    OpenUrlAbstract/FREE Full Text
  53. 53.↵
    1. Groves N,
    2. Tobin A
    . High flow nasal oxygen generates positive airway pressure in adult volunteers. Aust Crit Care 2007;20(4):126–131.
    OpenUrlCrossRefPubMed
  54. 54.↵
    1. Riera J,
    2. Pérez P,
    3. Cortés J,
    4. Roca O,
    5. Masclans JR,
    6. Rello J
    . Effect of high-flow nasal cannula and body position on end-expiratory lung volume: a cohort study using electrical impedance tomography. Respir Care 2013;58(4):589–596.
    OpenUrlAbstract/FREE Full Text
  55. 55.↵
    1. Parke RL,
    2. Bloch A,
    3. McGuinness SP
    . Effect of very-high-flow nasal therapy on airway pressure and end-expiratory lung impedance in healthy volunteers. Respir Care 2015;60(10):1397–1403.
    OpenUrlAbstract/FREE Full Text
  56. 56.
    1. Diab S,
    2. Fraser JF
    . Maintaining oxygenation successfully with high flow nasal cannula during diagnostic bronchoscopy on a postoperative lung transplant patient in the intensive care. Case Rep Crit Care 2014;2014:198262.
    OpenUrlPubMed
  57. 57.↵
    1. Moriyama K,
    2. Satoh T,
    3. Motoyasu A,
    4. Kohyama T,
    5. Kotani M,
    6. Kanai R,
    7. et al
    . High-flow nasal cannula therapy in a patient with reperfusion pulmonary edema following percutaneous transluminal pulmonary angioplasty. Case Rep Pulmonol 2014;2014:837612.
    OpenUrlPubMed
  58. 58.↵
    1. Boyer A,
    2. Vargas F,
    3. Delacre M,
    4. Saint-Léger M,
    5. Clouzeau B,
    6. Hilbert G,
    7. Gruson D
    . Prognostic impact of high-flow nasal cannula oxygen supply in an ICU patient with pulmonary fibrosis complicated by acute respiratory failure. Intensive Care Med 2011;37(3):558–559.
    OpenUrlCrossRefPubMedWeb of Science
  59. 59.↵
    1. Calvano TP,
    2. Sill JM,
    3. Kemp KR,
    4. Chung KK
    . Use of a high-flow oxygen delivery system in a critically ill patient with dementia. Respir Care 2008;53(12):1739–1743.
    OpenUrlAbstract/FREE Full Text
  60. 60.↵
    1. Díaz-Lobato S,
    2. Folgado MA,
    3. Chapa A,
    4. Mayoralas Alises S
    . Efficacy of high-flow oxygen by nasal cannula with active humidification in a patient with acute respiratory failure of neuromuscular origin. Respir Care 2013;58(12):e164–e167.
    OpenUrlAbstract/FREE Full Text
  61. 61.↵
    1. Miyagi K,
    2. Haranaga S,
    3. Higa F,
    4. Tateyama M,
    5. Fujita J
    . Implementation of bronchoalveolar lavage using a high-flow nasal cannula in five cases of acute respiratory failure. Respir Investig 2014;52(5):310–314.
    OpenUrlPubMed
  62. 62.↵
    1. Roca O,
    2. de Acilu MG,
    3. Caralt B,
    4. Sacanell J,
    5. Masclans JR
    . Humidified high flow nasal cannula supportive therapy improves outcomes in lung transplant recipients readmitted to the intensive care unit because of acute respiratory failure. Transplantation 2015;99(5):1092–1098.
    OpenUrlPubMed
  63. 63.↵
    1. Lee HY,
    2. Rhee CK,
    3. Lee JW
    . Feasibility of high-flow nasal cannula oxygen therapy for acute respiratory failure in patients with hematologic malignancies: a retrospective single-center study. J Crit Care 2015;30(4):773–777.
    OpenUrlPubMed
  64. 64.↵
    1. Brotfain E,
    2. Zlotnik A,
    3. Schwartz A,
    4. Frenkel A,
    5. Koyfman L,
    6. Gruenbaum SE,
    7. Klein M
    . Comparison of the effectiveness of high flow nasal oxygen cannula vs. standard non-rebreather oxygen face mask in post-extubation intensive care unit patients. Isr Med Assoc J 2014;16(11):718–722.
    OpenUrlPubMed
  65. 65.↵
    1. Kang BJ,
    2. Koh Y,
    3. Lim CM,
    4. Huh JW,
    5. Baek S,
    6. Han M,
    7. et al
    . Failure of high-flow nasal cannula therapy may delay intubation and increase mortality. Intensive Care Med 2015;41(4):623–632.
    OpenUrlCrossRefPubMed
  66. 66.↵
    1. Nilius G,
    2. Franke KJ,
    3. Domanski U,
    4. Rühle KH,
    5. Kirkness JP,
    6. Schneider H
    . Effects of nasal insufflation on arterial gas exchange and breathing pattern in patients with chronic obstructive pulmonary disease and hypercapnic respiratory failure. Adv Exp Med Biol 2013;755:27–34.
    OpenUrlCrossRefPubMed
  67. 67.↵
    1. McGinley B,
    2. Halbower A,
    3. Schwartz AR,
    4. Smith PL,
    5. Patil SP,
    6. Schneider H
    . Effect of a high-flow open nasal cannula system on obstructive sleep apnea in children. Pediatrics 2009;124(1):179–188.
    OpenUrlAbstract/FREE Full Text
  68. 68.↵
    1. Roca O,
    2. Pérez-Téran P,
    3. Masclans JR,
    4. Pérez L,
    5. Galve E,
    6. Evangelista A,
    7. Rello J
    . Patients with New York Heart Association class III heart failure may benefit with high flow nasal cannula supportive therapy: high flow nasal cannula in heart failure. J Crit Care 2013;28(5):741–746.
    OpenUrlPubMed
  69. 69.↵
    1. Lenglet H,
    2. Sztrymf B,
    3. Leroy C,
    4. Brun P,
    5. Dreyfuss D,
    6. Ricard JD
    . Humidified high flow nasal oxygen during respiratory failure in the emergency department: feasibility and efficacy. Respir Care 2012;57(11):1873–1878.
    OpenUrlAbstract/FREE Full Text
  70. 70.↵
    1. Parke R,
    2. McGuinness S,
    3. Dixon R,
    4. Jull A
    . Open-label, phase II study of routine high-flow nasal oxygen therapy in cardiac surgical patients. Br J Anaesth 2013;111(6):925–931.
    OpenUrlAbstract/FREE Full Text
  71. 71.↵
    1. Lucangelo U,
    2. Vassallo FG,
    3. Marras E,
    4. Ferluga M,
    5. Beziza E,
    6. Comuzzi L,
    7. et al
    . High-flow nasal interface improves oxygenation in patients undergoing bronchoscopy. Crit Care Res Pract 2012;2012:506382.
    OpenUrlPubMed
  72. 72.↵
    1. Corley A,
    2. Bull T,
    3. Spooner AJ,
    4. Barnett AG,
    5. Fraser JF
    . Direct extubation onto high-flow nasal cannulae post-cardiac surgery versus standard treatment in patients with a BMI ≥30: a randomised controlled trial. Intensive Care Med 2015;41(5):887–894.
    OpenUrlPubMed
  73. 73.↵
    1. Maggiore SM,
    2. Idone FA,
    3. Vaschetto R,
    4. Festa R,
    5. Cataldo A,
    6. Antonicelli F,
    7. et al
    . Nasal high-flow versus Venturi mask oxygen therapy after extubation: effects on oxygenation, comfort, and clinical outcome. Am J Respir Crit Care Med 2014;190(3):282–288.
    OpenUrlCrossRefPubMed
  74. 74.↵
    1. Vourc'h M,
    2. Asfar P,
    3. Volteau C,
    4. Bachoumas K,
    5. Clavieras N,
    6. Egreteau PY,
    7. et al
    . High-flow nasal cannula oxygen during endotracheal intubation in hypoxemic patients: a randomized controlled clinical trial. Intensive Care Med 2015;41(9):1538–1548.
    OpenUrlCrossRefPubMed
  75. 75.↵
    1. Dewan NA,
    2. Bell CW
    . Effect of low flow and high flow oxygen delivery on exercise tolerance and sensation of dyspnea: a study comparing the transtracheal catheter and nasal prongs. Chest 1994;105(4):1061–1065.
    OpenUrlCrossRefPubMedWeb of Science
  76. 76.↵
    1. Brochard L,
    2. Mancebo J,
    3. Wysocki M,
    4. Lofaso F,
    5. Conti G,
    6. Rauss A,
    7. et al
    . Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease. N Engl J Med 1995;333(13):817–822.
    OpenUrlCrossRefPubMedWeb of Science
  77. 77.↵
    1. Ozyilmaz E,
    2. Ugurlu AO,
    3. Nava S
    . Timing of noninvasive ventilation failure: causes, risk factors, and potential remedies. BMC Pulm Med 2014;14:19.
    OpenUrlPubMed
  78. 78.↵
    1. Nicolini A,
    2. Ferrera L,
    3. Santo M,
    4. Ferrari-Bravo M,
    5. Del Forno M,
    6. Sclifò F
    . Noninvasive ventilation for hypercapnic exacerbation of chronic obstructive pulmonary disease: factors related to noninvasive ventilation failure. Pol Arch Med Wewn 2014;124(10):525–531.
    OpenUrlPubMed
  79. 79.↵
    1. Millar J,
    2. Lutton S,
    3. O'Connor P
    . The use of high-flow nasal oxygen therapy in the management of hypercarbic respiratory failure. Ther Adv Respir Dis 2014;8(2):63–64.
    OpenUrlAbstract/FREE Full Text
  80. 80.↵
    1. Bräunlich J,
    2. Beyer D,
    3. Mai D,
    4. Hammerschmidt S,
    5. Seyfarth HJ,
    6. Wirtz H
    . Effects of nasal high flow on ventilation in volunteers, COPD and idiopathic pulmonary fibrosis patients. Respiration 2013;85(4):319–325.
    OpenUrlCrossRefPubMedWeb of Science
  81. 81.↵
    1. Chatila W,
    2. Nugent T,
    3. Vance G,
    4. Gaughan J,
    5. Criner GJ
    . The effects of high-flow vs low-flow oxygen on exercise in advanced obstructive airways disease. Chest 2004;126(4):1108–1115.
    OpenUrlCrossRefPubMed
  82. 82.↵
    1. Kelly GS,
    2. Simon HK,
    3. Sturm JJ
    . High-flow nasal cannula use in children with respiratory distress in the emergency department: predicting the need for subsequent intubation. Pediatr Emerg Care 2013;29(8):888–892.
    OpenUrlCrossRefPubMedWeb of Science
  83. 83.↵
    1. Rittayamai N,
    2. Tscheikuna J,
    3. Praphruetkit N,
    4. Kijpinyochai S
    . Use of high-flow nasal cannula for acute dyspnea and hypoxemia in the emergency department. Respir Care 2015;60(10):1377–1382.
    OpenUrlAbstract/FREE Full Text
  84. 84.↵
    1. Rello J,
    2. Pérez M,
    3. Roca O,
    4. Poulakou G,
    5. Souto J,
    6. Laborda C,
    7. et al
    . High-flow nasal therapy in adults with severe acute respiratory infection: a cohort study in patients with 2009 influenza A/H1N1v. J Crit Care 2012;27(5):434–439.
    OpenUrlCrossRefPubMedWeb of Science
  85. 85.↵
    1. Messika J,
    2. Ben Ahmed K,
    3. Gaudry S,
    4. Miguel-Montanes R,
    5. Rafat C,
    6. Sztrymf B,
    7. et al
    . Use of high-flow nasal cannula oxygen therapy in subjects with ARDS: a 1-year observational study. Respir Care 2015;60(2):162–169.
    OpenUrlAbstract/FREE Full Text
  86. 86.↵
    1. Torres A,
    2. Gatell JM,
    3. Aznar E,
    4. el-Ebiary M,
    5. Puig de la Bellacasa J,
    6. González J,
    7. et al
    . Re-intubation increases the risk of nosocomial pneumonia in patients needing mechanical ventilation. Am J Respir Crit Care Med 1995;152(1):137–141.
    OpenUrlCrossRefPubMedWeb of Science
  87. 87.↵
    1. Esteban A,
    2. Anzueto A,
    3. Frutos F,
    4. Alía I,
    5. Brochard L,
    6. Stewart TE,
    7. et al
    . Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA 2002;287(3):345–355.
    OpenUrlCrossRefPubMedWeb of Science
  88. 88.↵
    1. Tiruvoipati R,
    2. Lewis D,
    3. Haji K,
    4. Botha J
    . High-flow nasal oxygen vs high-flow face mask: a randomized crossover trial in extubated patients. J Crit Care 2010;25(3):463–468.
    OpenUrlCrossRefPubMedWeb of Science
  89. 89.↵
    1. Futier E,
    2. Paugam-Burtz C,
    3. Constantin JM,
    4. Pereira B,
    5. Jaber S
    . The OPERA trial: comparison of early nasal high flow oxygen therapy with standard care for prevention of postoperative hypoxemia after abdominal surgery: study protocol for a multicenter randomized controlled trial. Trials 2013;14:341.
    OpenUrlPubMed
  90. 90.↵
    1. Schwartz DE,
    2. Matthay MA,
    3. Cohen NH
    . Death and other complications of emergency airway management in critically ill adults: a prospective investigation of 297 tracheal intubations. Anesthesiology 1995;82(2):367–376.
    OpenUrlCrossRefPubMedWeb of Science
  91. 91.↵
    1. Mort TC
    . Emergency tracheal intubation: complications associated with repeated laryngoscopic attempts. Anesthesia Analgesia 2004;99(2):607–613, table of contents.
    OpenUrlCrossRefPubMedWeb of Science
  92. 92.↵
    1. Baillard C,
    2. Fosse JP,
    3. Sebbane M,
    4. Chanques G,
    5. Vincent F,
    6. Courouble P,
    7. et al
    . Noninvasive ventilation improves preoxygenation before intubation of hypoxic patients. Am J Respir Crit Care Med 2006;174(2):171–177.
    OpenUrlCrossRefPubMedWeb of Science
  93. 93.↵
    1. Miguel-Montanes R,
    2. Hajage D,
    3. Messika J,
    4. Bertrand F,
    5. Gaudry S,
    6. Rafat C,
    7. et al
    . Use of high-flow nasal cannula oxygen therapy to prevent desaturation during tracheal intubation of intensive care patients with mild-to-moderate hypoxemia. Crit Care Med 2015;43(3):574–583.
    OpenUrlCrossRefPubMed
  94. 94.↵
    1. Masip J,
    2. Betbesé AJ,
    3. Páez J,
    4. Vecilla F,
    5. Cañizares R,
    6. Padró J,
    7. et al
    . Non-invasive pressure support ventilation versus conventional oxygen therapy in acute cardiogenic pulmonary oedema: a randomised trial. Lancet 2000;356(9248):2126–2132.
    OpenUrlCrossRefPubMedWeb of Science
  95. 95.↵
    1. Cortuk M,
    2. Akyol S,
    3. Baykan AO,
    4. Kiraz K,
    5. Ucar H,
    6. Cayli M,
    7. et al
    . Aortic stiffness increases in proportion to the severity of apnoea-hypopnea index in patients with obstructive sleep apnoea syndrome. Clin Respir J 2014. doi: 10.111/crj.12244.
  96. 96.
    1. Sahlin C,
    2. Sandberg O,
    3. Gustafson Y,
    4. Bucht G,
    5. Carlberg B,
    6. Stenlund H,
    7. Franklin KA
    . Obstructive sleep apnea is a risk factor for death in patients with stroke: a 10-year follow-up. Arch Intern Med 2008;168(3):297–301.
    OpenUrlCrossRefPubMedWeb of Science
  97. 97.↵
    1. Fonseca MI,
    2. Pereira T,
    3. Caseiro P
    . Death and disability in patients with sleep apnea: a meta-analysis. Arq Bras Cardiol 2015;104(1):58–66.
    OpenUrlPubMed
  98. 98.↵
    1. Marcus CL,
    2. Rosen G,
    3. Ward SL,
    4. Halbower AC,
    5. Sterni L,
    6. Lutz J,
    7. et al
    . Adherence to and effectiveness of positive airway pressure therapy in children with obstructive sleep apnea. Pediatrics 2006;117(3):e442–e451.
    OpenUrlAbstract/FREE Full Text
  99. 99.↵
    1. McGinley BM,
    2. Patil SP,
    3. Kirkness JP,
    4. Smith PL,
    5. Schwartz AR,
    6. Schneider H
    . A nasal cannula can be used to treat obstructive sleep apnea. Am J Respir Crit Care Med 2007;176(2):194–200.
    OpenUrlCrossRefPubMedWeb of Science
  100. 100.↵
    1. Haba-Rubio J,
    2. Andries D,
    3. Rey-Bataillard V,
    4. Michel P,
    5. Tafti M,
    6. Heinzer R
    . Effect of transnasal insufflation on sleep-disordered breathing in acute stroke. Sleep Breath 2015;19(1):3.
    OpenUrlPubMed
  101. 101.↵
    1. Schettino G,
    2. Altobelli N,
    3. Kacmarek RM
    . Noninvasive positive pressure ventilation reverses acute respiratory failure in select “do-not-intubate” patients. Crit Care Med 2005;33(9):1976–1982.
    OpenUrlCrossRefPubMedWeb of Science
  102. 102.↵
    1. Levy M,
    2. Tanios MA,
    3. Nelson D,
    4. Short K,
    5. Senechia A,
    6. Vespia J,
    7. Hill NS
    . Outcomes of patients with do-not-intubate orders treated with noninvasive ventilation. Crit Care Med 2004;32(10):2002–2007.
    OpenUrlCrossRefPubMedWeb of Science
  103. 103.↵
    1. Byerly FL,
    2. Haithcock JA,
    3. Buchanan IB,
    4. Short KA,
    5. Cairns BA
    . Use of high flow nasal cannula on a pediatric burn patient with inhalation injury and post-extubation stridor. Burns 2006;32(1):121–125.
    OpenUrlCrossRefPubMed
  104. 104.↵
    1. Esteban A,
    2. Frutos-Vivar F,
    3. Ferguson ND,
    4. Arabi Y,
    5. Apezteguía C,
    6. González M,
    7. et al
    . Noninvasive positive-pressure ventilation for respiratory failure after extubation. N Engl J Med 2004;350(24):2452–2460.
    OpenUrlCrossRefPubMedWeb of Science
  105. 105.↵
    1. Moretti M,
    2. Cilione C,
    3. Tampieri A,
    4. Fracchia C,
    5. Marchioni A,
    6. Nava S
    . Incidence and causes of non-invasive mechanical ventilation failure after initial success. Thorax 2000;55(10):819–825.
    OpenUrlAbstract/FREE Full Text
  106. 106.↵
    1. Carrillo A,
    2. Gonzalez-Diaz G,
    3. Ferrer M,
    4. Martinez-Quintana ME,
    5. Lopez-Martinez A,
    6. Llamas N,
    7. et al
    . Non-invasive ventilation in community-acquired pneumonia and severe acute respiratory failure. Intensive Care Med 2012;38(3):458–466.
    OpenUrlCrossRefPubMedWeb of Science
  107. 107.↵
    1. Hegde S,
    2. Prodhan P
    . Serious air leak syndrome complicating high-flow nasal cannula therapy: a report of 3 cases. Pediatrics 2013;131(3):e939–e944.
    OpenUrlAbstract/FREE Full Text
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Respiratory Care: 61 (4)
Respiratory Care
Vol. 61, Issue 4
1 Apr 2016
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High-Flow Nasal Cannula Oxygen Therapy in Adults: Physiological Benefits, Indication, Clinical Benefits, and Adverse Effects
Masaji Nishimura
Respiratory Care Apr 2016, 61 (4) 529-541; DOI: 10.4187/respcare.04577

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High-Flow Nasal Cannula Oxygen Therapy in Adults: Physiological Benefits, Indication, Clinical Benefits, and Adverse Effects
Masaji Nishimura
Respiratory Care Apr 2016, 61 (4) 529-541; DOI: 10.4187/respcare.04577
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  • Article
    • Abstract
    • Introduction
    • Adverse Effects of Lack of Humidification
    • Humidification Performance of HFNC Devices
    • Interface
    • Physiological Effect
    • Fraction of Inspired Oxygen
    • PEEP Effect
    • Clinical Trials
    • Hypercapnic Respiratory Failure
    • Hypoxemic Respiratory Failure
    • Postextubation
    • Preintubation Oxygenation
    • Acute Heart Failure
    • Sleep Apnea
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Keywords

  • noninvasive ventilation
  • high-flow oxygen therapy
  • escalation
  • randomized
  • controlled trials
  • humidification

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