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Research ArticleOriginal Research

Prophylactic Use of Nebulized Hypertonic Saline in Mechanically Ventilated Children: A Randomized Blinded Pilot Study

Steven L Shein, John T Gallagher, Kathleen M Deakins and Dayna M Weinert
Respiratory Care May 2016, 61 (5) 586-592; DOI: https://doi.org/10.4187/respcare.04418
Steven L Shein
Division of Critical Care Medicine, Rainbow Babies and Children's Hospital, and the Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio.
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  • For correspondence: [email protected]
John T Gallagher
Division of Respiratory Care, Rainbow Babies and Children's Hospital, Cleveland, Ohio.
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Kathleen M Deakins
Division of Respiratory Care, Rainbow Babies and Children's Hospital, Cleveland, Ohio.
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Dayna M Weinert
Division of Radiology, Rainbow Babies and Children's Hospital, and the Department of Radiology, Case Western Reserve University School of Medicine, Cleveland, Ohio.
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    Flow chart.

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    Fig. 2.

    Chest radiograph scores at baseline and the average of all post-enrollment scores. Scores ranged from 0 to 3 for each of the 5 lobes of the lungs (15 is the worst possible cumulative score). Scores did not differ significantly in either group between baseline and post-enrollment. The difference between baseline levels between groups approached significance (P = .09). Points represent median; error bars denote interquartile range.

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    Fig. 3.

    Mechanical ventilator parameters before and after drug administration. There were no differences between the before and after values in either group. Several parameters differed before drug administration between groups, suggesting worse respiratory mechanics in the hypertonic saline group. Data are shown as median; error bars denote interquartile range. Cdyn = dynamic compliance of the respiratory system; PIP = peak inspiratory pressure; VT = tidal volume; PETCO2 = end-tidal CO2. *, P < .05.

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Respiratory Care: 61 (5)
Respiratory Care
Vol. 61, Issue 5
1 May 2016
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Prophylactic Use of Nebulized Hypertonic Saline in Mechanically Ventilated Children: A Randomized Blinded Pilot Study
Steven L Shein, John T Gallagher, Kathleen M Deakins, Dayna M Weinert
Respiratory Care May 2016, 61 (5) 586-592; DOI: 10.4187/respcare.04418

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Prophylactic Use of Nebulized Hypertonic Saline in Mechanically Ventilated Children: A Randomized Blinded Pilot Study
Steven L Shein, John T Gallagher, Kathleen M Deakins, Dayna M Weinert
Respiratory Care May 2016, 61 (5) 586-592; DOI: 10.4187/respcare.04418
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Keywords

  • Pediatric
  • hypertonic saline
  • mechanical ventilation

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