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Research ArticleOriginal Research

Cystatin C as a Predictor of In-Hospital Mortality After Exacerbation of COPD

Guoping Hu, Yankui Wu, Yumin Zhou, Yan Yu, Weiqiang Liang and Pixin Ran
Respiratory Care July 2016, 61 (7) 950-957; DOI: https://doi.org/10.4187/respcare.04034
Guoping Hu
Department of Respiratory Medicine, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
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Yankui Wu
Department of Respiratory Disease, People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Zhuang Autonomous Region, China.
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Yumin Zhou
Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
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Yan Yu
Department of Respiratory Medicine, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
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Weiqiang Liang
Department of Respiratory Medicine, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
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Pixin Ran
Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
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    Fig. 1.

    A receiver operator characteristic curve for plasma cystatin C as an overall predictor of death in subjects with COPD exacerbation. Area under the receiver operator characteristic curve = 0.77 (95% CI 0.70–0.84).

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    Fig. 2.

    Cystatin C levels (mg/L) in survivor and non-survivor subjects with COPD exacerbation stratified by the comorbid presence of renal dysfunction (A) and congestive heart failure (B) at the time of admission. Boxes show first and third quartiles, center lines denote the median, and whiskers show the minimum and maximum. * P < .05.

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    Fig. 3.

    Cystatin C levels (mg/L) in the survivor and non-survivor subjects with COPD exacerbation stratified by the levels of pH (A), PaO2 (B), and PaCO2 (C). Low pH is <7.35, and high pH is >7.35; low PaO2 is <60 mm Hg, and high PaO2 is ≥60 mm Hg; low PaCO2 is <50 mm Hg, and high PaCO2 is ≥50 mm Hg. Boxes show first and third quartiles, center lines denote the median, and whiskers show the minimum and maximum. * P < .05.

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Respiratory Care: 61 (7)
Respiratory Care
Vol. 61, Issue 7
1 Jul 2016
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Cystatin C as a Predictor of In-Hospital Mortality After Exacerbation of COPD
Guoping Hu, Yankui Wu, Yumin Zhou, Yan Yu, Weiqiang Liang, Pixin Ran
Respiratory Care Jul 2016, 61 (7) 950-957; DOI: 10.4187/respcare.04034

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Cystatin C as a Predictor of In-Hospital Mortality After Exacerbation of COPD
Guoping Hu, Yankui Wu, Yumin Zhou, Yan Yu, Weiqiang Liang, Pixin Ran
Respiratory Care Jul 2016, 61 (7) 950-957; DOI: 10.4187/respcare.04034
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Keywords

  • COPD exacerbation
  • cystatin C
  • mortality
  • prognosis

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