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LetterCorrespondence

Continuous Mouthpiece Daytime Amyotrophic Lateral Sclerosis in Noninvasive Ventilation: Definitive Solid Therapy?

Giuseppe Fiorentino and Antonio M Esquinas
Respiratory Care March 2017, 62 (3) 387; DOI: https://doi.org/10.4187/respcare.05229
Giuseppe Fiorentino
Respiratory Unit AO Ospedali dei Colli Monaldi Naples, Italy
MD
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Antonio M Esquinas
Intensive Care Unit Hospital Morales Meseguer Murcia, Spain
MD PhD
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To the Editor:

Treatment options for amyotrophic lateral sclerosis (ALS) are very limited.1 In some cases, noninvasive ventilation (NIV) by mouthpiece ventilation is a technique that is useful in the treatment of chronic ventilatory failure, particularly in neuromuscular patients.2 The literature on mouthpiece ventilation in ALS is limited, and there are no published evidence-based guidelines concerning mouthpiece ventilation. Its application is mainly based on the experience of a few centers. Mouthpiece ventilation is particularly useful when there are problems with conventional masks. Patient selection for adequate bulbar muscle function is of paramount importance, and in these patients, mouthpiece ventilation was shown to be an effective alternative to tracheostomy, optimizing convenience and communication.

We have read with great interest the study by Bédard and McKim3 that concludes that mouthpiece ventilation is a safe, convenient, and effective way to provide NIV in ALS with adequate bulbar function requiring continuous ventilatory support. Although this study shows an original contribution for NIV in severe ALS, we believe that there are some key issues that require evaluation.

First, the addition of mouthpiece ventilation was based primarily on the objective of improving quality of life related to prolonged hours of inconvenient and uncomfortable mask use (>12 h daily) (24 of 37 subjects) and symptoms of dyspnea (9 of 37 subjects).3 We believe other aspects need to be considered.

Second, the evaluation of bulbar function remains subjective as a clinical assessment, where some clinical tests (swallowing and speech) and patient recall define the level of bulbar involvement. This is in contrast to the evaluation of ventilation, where several objective functional markers are followed through time. Of all of the routine respiratory tests ordered, cough peak flow is the only test that reflects bulbar function in addition to inspiratory and expiratory muscle function. The difference between cough peak flow and peak expiratory flow has thus been proposed to measure bulbar involvement.4

Third, the bulbar subscores of the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale discriminated between those subjects having sufficient bulbar function to succeed with mouthpiece ventilation and those who did not. It seems to be a simple and useful tool to assess candidacy for mouthpiece ventilation. In this study, the scores' cutoff points are arbitrary, and no study has defined a cutoff that accurately reflects an objectively measured clinical impairment. We need a more accurate way to detect and quantify the level of bulbar involvement.4 For example, a specific test of bulbar function may help to recognize the group of patients at higher risk of NIV failure or in need of early initiation of mechanical cough assistance, or it may simply help to better classify/quantify bulbar involvement4 Further prospective clinical trials to confirm the efficacy of mouthpiece ventilation should be offered as a rational alternative to tracheostomy for individuals able to hold a mouthpiece, particularly in individuals with non-bulbar ALS needing continuous ventilatory support.

Footnotes

  • The authors have disclosed no conflicts of interest.

  • Copyright © 2017 by Daedalus Enterprises

References

  1. 1.↵
    1. Bourke SC,
    2. Steer J
    . Practical respiratory management in amyotrophic lateral sclerosis: evidence, controversies and recent advances. Neurodegener Dis Manag 2016;6(2):147–160.
    OpenUrl
  2. 2.↵
    1. Aboussouan LS,
    2. Mireles-Cabodevila E
    . Respiratory support in patients with amyotrophic lateral sclerosis. Respir Care 2013;58(9):1555–1558.
    OpenUrlFREE Full Text
  3. 3.↵
    1. Bédard ME,
    2. McKim DA
    . Daytime mouthpiece for continuous noninvasive ventilation in individuals with amyotrophic lateral sclerosis. Respir Care 2016;61(10):1341–1348.
    OpenUrlAbstract/FREE Full Text
  4. 4.↵
    1. Suárez AA,
    2. Pessolano FA,
    3. Monteiro SG,
    4. Ferreyra G,
    5. Capria ME,
    6. Mesa L,
    7. et al
    . Peak flow and peak cough flow in the evaluation of expiratory muscle weakness and bulbar impairment in patients with neuromuscular disease. Am J Phys Med Rehabil 2002;81(7):506–511.
    OpenUrlCrossRefPubMed
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Respiratory Care: 62 (3)
Respiratory Care
Vol. 62, Issue 3
1 Mar 2017
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Continuous Mouthpiece Daytime Amyotrophic Lateral Sclerosis in Noninvasive Ventilation: Definitive Solid Therapy?
Giuseppe Fiorentino, Antonio M Esquinas
Respiratory Care Mar 2017, 62 (3) 387; DOI: 10.4187/respcare.05229

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Continuous Mouthpiece Daytime Amyotrophic Lateral Sclerosis in Noninvasive Ventilation: Definitive Solid Therapy?
Giuseppe Fiorentino, Antonio M Esquinas
Respiratory Care Mar 2017, 62 (3) 387; DOI: 10.4187/respcare.05229
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