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ReplyCorrespondence

Continuous Mouthpiece Daytime Amyotrophic Lateral Sclerosis in Noninvasive Ventilation: Definitive Solid Therapy?—Reply

Marie-Eve Bédard and Douglas A McKim
Respiratory Care March 2017, 62 (3) 387-388; DOI: https://doi.org/10.4187/respcare.05453
Marie-Eve Bédard
University Laval Québec, Québec, Canada
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Douglas A McKim
University of Ottawa Ottawa, Ontario, Canada
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In reply:

We appreciate very much the opportunity to respond to the letter from Drs Fiorentino and Esquinas with regard to our publication on mouthpiece ventilation in amyotrophic lateral sclerosis (ALS).1 We are pleased that it was read with great interest, and we sincerely thank our subjects for allowing us the opportunity to document the effectiveness of mouthpiece ventilation. Providing ventilator support and airway clearance to individuals with ALS is often challenging; therefore, developing more accurate means of assessment and novel techniques of support, such as mouthpiece ventilation, is critical, particularly in avoiding unnecessary tracheostomy placement.

We are in full agreement with many of the statements expressed in this letter and recognize the importance of mutual effort in establishing evidence-based and best practices in the respiratory care of those with ALS. Sadly, even in the Canadian Thoracic Society clinical practice guideline on home mechanical ventilation,2 there are no specific recommendations for mouthpiece ventilation for patients with ALS, although there are for patients with Duchenne muscular dystrophy. The recommendations for up to 24-h noninvasive ventilation (NIV), rather than tracheostomy, although not explicit, could be interpreted to include mouthpiece ventilation, clearly a form of NIV. We also agree that the paper demonstrates that mouthpiece ventilation is safe, convenient, and effective and that, indeed, key issues are still in need of further evaluation.

In particular, we agree entirely that a more objective assessment of bulbar function and its potentially predictive relationship to success with mouthpiece ventilation would be helpful rather than relying on the first 3 questions of the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale score, referred to as the bulbar subscore (b-ALSFRS-R). Within individuals, this score may vary from time to time, and in our experience, it may differ significantly from a more objective clinician assessment. However, we do not have consistent access to more objective measures of bulbar function and must rely on this value as a subjective estimate. It may also be of greater utility in studying populations of ALS patients as opposed to single individuals. Not even we, however, would rely entirely upon a single threshold in the b-ALSFRS-R score (<6/12) to exclude a patient from mouthpiece ventilation, but we would rely on an adequate clinical trial, particularly in the absence of prospective studies establishing a more discriminative threshold in a larger population of individuals with ALS. Hence, a small number of subjects were included whose b-ALSFRS-R score was low but who seemed at least initially to be capable and motivated enough to grip the mouthpiece. Even prospective trials may not be able to adequately address the question of sufficient bulbar function for mouthpiece ventilation in given individuals. In the same way that clinically, individuals with severe bulbar ALS with low cough peak flows may not be expected to tolerate NIV or mechanical in-exsufflation based on objective evaluation and published experience,3–6 much to our surprise, many do. As a result, we suspect that even prospectively established, objective cutoffs will not replace adequate clinical trials of mask NIV, mechanical in-exsufflation, or mouthpiece ventilation.

While we also agree that cough peak flow is an excellent assessment of bulbar function, we would not suggest that it “is the only test that reflects bulbar function.” Although glottic function is clearly necessary to enhance expiratory flows above those observed with forced exhalation alone, in our experience, the difference between the maximum insufflation capacity and vital capacity is an equally robust measure of glottic and bulbar function. In fact, the difference between the maximum insufflation capacity and vital capacity has been demonstrated to correlate highly with cough peak flow in a population with Duchenne muscular dystrophy.7 Clinically, some individuals may fail to demonstrate an enhanced cough peak flow greater than the peak expiratory flow but may still demonstrate a considerable difference between maximum insufflation capacity and vital capacity. As such, we would prefer to rely on either measure or both to help define those who are more likely to manage mouthpiece ventilation effectively.

Further discussion would also be appropriate with regard to the suggestion that mouthpiece ventilation is “particularly useful when there are problems with conventional masks.” Rather, mouthpiece ventilation is introduced precisely to replace even perfectly comfortable and effective masks and expressly to provide independence from them. Indeed, mouthpiece ventilation facilitates speech, swallowing, and, perhaps most importantly, the ability to autonomously perform regular lung volume recruitment to increase cough peak flow, maintain airway clearance, and possibly improve respiratory mechanics, all critical activities that cannot be performed with mask NIV. Furthermore, the suggestion that “other aspects [besides quality of life] need to be taken into account,” if implying that the symptom of dyspnea and/or prolonged use of mask NIV is not a legitimate, sole indication for mouthpiece ventilation and that more objective measure are required, is to suggest that ALS patients experiencing daytime dyspnea need to remain on a confining mask and not be relieved or permitted the ability to perform autonomous lung volume recruitment until more objective signs, such as, presumably, daytime hypercapnia, are identified. To establish definitively the survival benefit of mouthpiece ventilation in ALS, hypercapnia might be necessary, but to provide independence and quality of life in breathing, communicating, and taking nutrition by mouth, it is not. We would continue to advocate that, in those capable of retaining and using a mouthpiece, the introduction of mouthpiece ventilation should occur as soon as the daily amount of mask ventilation exceeds 12 h or whatever time threshold will provide the patient with comfort, relief of dyspnea, and effective daytime ventilation as well as autonomous airway clearance.

We join you in the anticipation of future trials that will better define optimum candidates and the role of mouthpiece ventilation in the respiratory management of individuals with ALS.

Footnotes

  • The authors have disclosed no conflicts of interest.

  • Copyright © 2017 by Daedalus Enterprises

REFERENCES

  1. 1.↵
    1. Bédard ME,
    2. McKim DA
    . Daytime mouthpiece for continuous noninvasive ventilation in individuals with amyotrophic lateral sclerosis. Respir Care 2016;61(10):1341–1348.
    OpenUrlAbstract/FREE Full Text
  2. 2.↵
    1. McKim DA,
    2. Road J,
    3. Avendano M,
    4. Abdool S,
    5. Cote F,
    6. Duguid N,
    7. et al
    . Home mechanical ventilation: a Canadian Thoracic Society clinical practice guideline. Can Respir J 2011;18(4):197–215.
    OpenUrlPubMed
  3. 3.↵
    1. Sancho J,
    2. Servera E,
    3. Díaz J,
    4. Marín J
    . Efficacy of mechanical insufflation-exsufflation in medically stable patients with amyotrophic lateral sclerosis. Chest 2004;125(4):1400–1405.
    OpenUrlCrossRefPubMed
  4. 4.
    1. Bourke SC,
    2. Bullock RE,
    3. Williams TL,
    4. Shaw PJ,
    5. Gibson GJ
    . Noninvasive ventilation in ALS: indications and effect on quality of life. Neurology 2003;61(2):171–177.
    OpenUrlCrossRefPubMed
  5. 5.
    1. Gruis KL,
    2. Brown DL,
    3. Lisabeth LD,
    4. Zebarah VA,
    5. Chervin RD,
    6. Feldman EL
    . Longitudinal assessment of noninvasive positive pressure ventilation adjustments in ALS patients. J Neurol Sci 2006;247(1):59–63.
    OpenUrlPubMed
  6. 6.↵
    1. Aboussouan LS,
    2. Khan SU,
    3. Meeker DP,
    4. Stelmach K,
    5. Mitsumoto H
    . Effect of noninvasive positive-pressure ventilation on survival in amyotrophic lateral sclerosis. Ann Intern Med 1997;127(6):450–453.
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Kang SW,
    2. Kang YS,
    3. Moon JH,
    4. Yoo TW
    . Assisted cough and pulmonary compliance in patients with Duchenne muscular dystrophy. Yonsei Med J 2005;46(2):233–238.
    OpenUrlCrossRefPubMed
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Respiratory Care: 62 (3)
Respiratory Care
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1 Mar 2017
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Continuous Mouthpiece Daytime Amyotrophic Lateral Sclerosis in Noninvasive Ventilation: Definitive Solid Therapy?—Reply
Marie-Eve Bédard, Douglas A McKim
Respiratory Care Mar 2017, 62 (3) 387-388; DOI: 10.4187/respcare.05453

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Continuous Mouthpiece Daytime Amyotrophic Lateral Sclerosis in Noninvasive Ventilation: Definitive Solid Therapy?—Reply
Marie-Eve Bédard, Douglas A McKim
Respiratory Care Mar 2017, 62 (3) 387-388; DOI: 10.4187/respcare.05453
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