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Research ArticleConference Proceedings

Pediatric Aerosol Therapy

Ariel Berlinski
Respiratory Care June 2017, 62 (6) 662-677; DOI: https://doi.org/10.4187/respcare.05298
Ariel Berlinski
Pulmonary Medicine Section, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas and the Pediatric Aerosol Research Laboratory, Arkansas Children's Research Institute. Little Rock, Arkansas.
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References

  1. 1.↵
    National Asthma Education and Prevention Program. National Heart, Lung, and Blood Institute, National Institutes of Health. Expert panel report 3: guidelines for the diagnosis and management of asthma. NIH publication No 08-4051, Bethesda, MD: National Institutes of Health; 2007. http://www.nhlbi.nih.gov/health-pro/guidelines/current/asthma-guidelines. Accessed March 10, 2017.
  2. 2.
    1. Abadesso C,
    2. Nunes P,
    3. Silvestre C,
    4. Matias E,
    5. Loureiro H,
    6. Almeida H
    . Non-invasive ventilation in acute respiratory failure in children. Pediatr Rep 2012;4(2):e16.
    OpenUrlPubMed
  3. 3.
    1. ten Brink F,
    2. Duke T,
    3. Evans J
    . High-flow nasal prong oxygen therapy or nasopharyngeal continuous positive airway pressure for children with moderate-to-severe respiratory distress? Pediatr Crit Care Med 2013;14(7):e326–e331.
    OpenUrlCrossRefPubMed
  4. 4.↵
    1. Willis LD,
    2. Berlinski A
    . Survey of aerosol delivery techniques to spontaneously breathing tracheostomized children. Respir Care 2012;57(8):1234–1241.
    OpenUrlAbstract/FREE Full Text
  5. 5.↵
    1. DiBlasi RM
    . Clinical controversies in aerosol therapy for infants and children. Respir Care 2015;60(6):894–914; discussion 914-916.
    OpenUrlAbstract/FREE Full Text
  6. 6.↵
    1. 't Jong GW,
    2. Eland IA,
    3. Sturkenboom MCJM,
    4. van den Anker JN,
    5. Stricker BHC
    . Unlicensed and off-label prescription of respiratory drugs to children. Eur Respir J 2004;23(2):310–313.
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. Amirav I,
    2. Newhouse MT,
    3. Minocchieri S,
    4. Castro-Rodriguez JA,
    5. Schüepp KG
    . Factors that affect the efficacy of inhaled corticosteroids for infants and young children. J Allergy Clin Immunol 2010;125(6):1206–1211.
    OpenUrlPubMed
  8. 8.↵
    1. Hanania NA,
    2. Wittman R,
    3. Kesten S,
    4. Chapman KR
    . Medical personnel's knowledge of and ability to use inhaling devices: metered-dose inhalers, spacing chambers, and breath-actuated dry powder inhalers. Chest 1994;105(1):111–116.
    OpenUrlCrossRefPubMedWeb of Science
  9. 9.↵
    1. Giner J,
    2. Roura P,
    3. Hernández C,
    4. Torrejón M,
    5. Peiró M,
    6. Fernández MJ,
    7. et al
    . Knowledge and attitudes of nurses in spain about inhaled therapy: results of a national survey. J Aerosol Med Pulm Drug Deliv 2016;29(1):86–93. doi: 10.1089/jamp.2014.1198.
    OpenUrl
  10. 10.↵
    1. Castro-Rodriguez JA,
    2. Rodrigo GJ
    . Beta-agonists through metered-dose inhaler with valved holding chamber versus nebulizer for acute exacerbation of wheezing or asthma in children under 5 years of age: a systematic review with meta-analysis. J Pediatr 2004;145(2):172–177.
    OpenUrlCrossRefPubMedWeb of Science
  11. 11.↵
    1. Cates CJ,
    2. Welsh EJ,
    3. Rowe BH
    . Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma. Cochrane Database Syst Rev 2013;(9):CD000052.
  12. 12.↵
    1. Salyer JW,
    2. DiBlasi RM,
    3. Crotwell DN,
    4. Cowan CA,
    5. Carter ER
    . The conversion to metered-dose inhaler with valved holding chamber to administer inhaled albuterol: a pediatric hospital experience. Respir Care 2008;53(3):338–345.
    OpenUrlAbstract/FREE Full Text
  13. 13.↵
    ProAirR HFA Package Insert. Highlights of prescribing information. Horsham, Pennsylvania: Teva Respiratory; Revised June 2016.
  14. 14.
    ProventilR HFA Package Insert. Prescribing information. Kenilworth, New Jersey: Schering-Plough Corporation; Revised December 2014.
  15. 15.↵
    VentolinR HFA Package Insert. Highlights of prescribing information. Brentford, United Kingdom: GlaxoSmithKline; Revised December 2014.
  16. 16.↵
    1. Berlinski A,
    2. Pennington D
    . Effect of interval between actuations of albuterol HFA inhalers on their aerosol characteristics (abstract). Eur Respir J 2016;48(Suppl 60):A3363.
    OpenUrl
  17. 17.↵
    1. Chua HL,
    2. Collis GG,
    3. Newbury AM,
    4. Chan K,
    5. Bower GD,
    6. Sly PD,
    7. Le Souef PN
    . The influence of age on aerosol deposition in children with cystic fibrosis. Eur Respir J 1994;7(12):2185–2191.
    OpenUrlAbstract/FREE Full Text
  18. 18.↵
    1. Amirav I,
    2. Luder A,
    3. Chleechel A,
    4. Newhouse MT,
    5. Gorenberg M
    . Lung aerosol deposition in suckling infants. Arch Dis Child 2012;97(6):497–501.
    OpenUrlAbstract/FREE Full Text
  19. 19.↵
    1. Mallol J,
    2. Rattray S,
    3. Walker G,
    4. Cook D,
    5. Robertson CF
    . Aerosol deposition in infants with cystic fibrosis. Pediatr Pulmonol 1996;21(5):276–281.
    OpenUrlCrossRefPubMed
  20. 20.↵
    1. Schüepp KG,
    2. Devadson S,
    3. Roller C,
    4. Wildhaber JH
    . A complementary combination of delivery device and drug formulation for inhalation therapy in preschool children. Swiss Med Wkly 2004;134(13-14):198–200.
    OpenUrlPubMed
  21. 21.↵
    1. Amirav I,
    2. Borojeni AA,
    3. Halamish A,
    4. Newhouse MT,
    5. Golshahi L
    . Nasal versus oral aerosol delivery to the “lungs” in infants and toddlers. Pediatr Pulmonol 2015;50(3):276–283. doi: 10.1002/ppul.22999.
    OpenUrl
  22. 22.↵
    1. Xi J,
    2. Si X,
    3. Kim JW,
    4. Berlinski A
    . Simulation of airflow and aerosol deposition in the nasal cavity of a 5-year-old child. J Aerosol Sci 2011;42(3):156–173.
    OpenUrl
  23. 23.↵
    1. El Taoum KK,
    2. Xi J,
    3. Kim J,
    4. Berlinski A
    . In-vitro evaluation of nebulized aerosols delivered via nasal route. Respir Care 2015;60(7):1015–1025.
    OpenUrlAbstract/FREE Full Text
  24. 24.↵
    1. Berlinski A,
    2. Xi J
    . Characterization of nebulized aerosols using a next generation impactor and an anatomically correct pediatric airway model. Respir Drug Deliv 2014;3:637–640.
    OpenUrl
  25. 25.↵
    1. Berlinski A,
    2. Hayden JB
    . Optimization of a procedure used to measure aerosol characteristics of nebulized solutions using a cooled next generation impactor. J Aerosol Med Pulm Drug Deliv 2010;23(6):397–404.
    OpenUrlPubMed
  26. 26.↵
    1. Cooper B,
    2. Berlinski A
    . Albuterol delivery via facial and tracheostomy route in a model of a spontaneously breathing child. Respir Care 2015;60(12):1749–1758.
    OpenUrlAbstract/FREE Full Text
  27. 27.↵
    1. Janssens HM,
    2. de Jongste JC,
    3. Fokkens WJ,
    4. Robben SG,
    5. Wouters K,
    6. Tiddens HA
    . The Sophia Anatomical Infant Nose-Throat (Saint) model: a valuable tool to study aerosol deposition in infants. J Aerosol Med 2001;14(4):433–441.
    OpenUrlPubMed
  28. 28.↵
    1. Janssens HM,
    2. De Jongste JC,
    3. Hop WC,
    4. Tiddens HA
    . Extra-fine particles improve lung delivery of inhaled steroids in infants: a study in an upper airway model. Chest 2003;123(6):2083–2088.
    OpenUrlCrossRefPubMedWeb of Science
  29. 29.↵
    1. Bhashyam AR,
    2. Wolf MT,
    3. Marcinkowski AL,
    4. Saville A,
    5. Thomas K,
    6. Carcillo JA,
    7. Corcoran TE
    . Aerosol delivery through nasal cannulas: an in vitro study. J Aerosol Med Pulm Drug Deliv 2008;21(2):181–188.
    OpenUrlPubMed
  30. 30.↵
    1. Longest PW,
    2. Golshahi L,
    3. Hindle M
    . Improving pharmaceutical aerosol delivery during noninvasive ventilation: effects of streamlined components. Ann Biomed Eng 2013;41(6):1217–1232.
    OpenUrlPubMed
  31. 31.↵
    1. Ari A,
    2. Harwood R,
    3. Sheard M,
    4. Dailey P,
    5. Fink JB
    . In vitro comparison of heliox and oxygen in aerosol delivery using pediatric high flow nasal cannula. Pediatr Pulmonol 2011;46(8):795–801.
    OpenUrlCrossRefPubMed
  32. 32.↵
    1. Perry SA,
    2. Kesser KC,
    3. Geller DE,
    4. Selhorst DM,
    5. Rendle JK,
    6. Hertzog JH
    . Influences of cannula size and flow rate on aerosol drug delivery through the Vapotherm humidified high-flow nasal cannula system. Pediatr Crit Care Med 2013;14(5):e250–e256.
    OpenUrlPubMed
  33. 33.↵
    1. Réminiac F,
    2. Vecellio L,
    3. Heuzé-Vourc'h N,
    4. Petitcollin A,
    5. Respaud R,
    6. Cabrera M,
    7. et al
    . Aerosol therapy in adults receiving high flow nasal cannula oxygen therapy. J Aerosol Med Pulm Drug Deliv 2016;29(2):134–141.
    OpenUrl
  34. 34.↵
    1. Réminiac F,
    2. Vecellio L,
    3. Loughlin RM,
    4. Le Pennec D,
    5. Cabrera M,
    6. Vourc'h NH,
    7. et al
    . Nasal high flow nebulization in infants and toddlers: An in vitro and in vivo scintigraphic study. Pediatr Pulmonol 2017;52(3):337–344.
    OpenUrl
  35. 35.↵
    1. O'Brien KC,
    2. Newth CJL,
    3. Leung K,
    4. Coates A
    . Epinephrine delivery using a humidified high flow oxygen delivery system (abstract). Am J Respir Crit Care Med 2007;175:A195.
    OpenUrl
  36. 36.↵
    1. Leung K,
    2. Newth CJ,
    3. Hotz JC,
    4. O'Brien KC,
    5. Fink JB,
    6. Coates AL
    . Delivery of epinephrine in the vapor phase for the treatment of croup. Pediatr Crit Care Med 2016;17(4):e177–e181.
    OpenUrl
  37. 37.↵
    1. Farney KD,
    2. Kuehne BT,
    3. Gibson LA,
    4. Nelin LD,
    5. Shepherd EG
    . In vitro evaluation of radio-labeled aerosol delivery via a variable-flow infant CPAP system. Respir Care 2014;59(3):340–344.
    OpenUrlAbstract/FREE Full Text
  38. 38.↵
    1. Boucher P,
    2. Boucher R,
    3. Button BM,
    4. Johnson MR,
    5. Fink JB,
    6. Hickey AJ,
    7. et al
    . Aerosol delivery systems, compositions and methods. United States Patent 20140109899 A1. http://www.google.com/patents/US20140109899. Accessed March 10, 2017.
  39. 39.↵
    1. Morgan SE,
    2. Mosakowski S,
    3. Solano P,
    4. Hall JB,
    5. Tung A
    . High-flow nasal cannula and aerosolized β agonists for rescue therapy in children with bronchiolitis: a case series. Respir Care 2015;60(9):e161–e165.
    OpenUrlAbstract/FREE Full Text
  40. 40.↵
    1. Longest PW,
    2. Golshahi L,
    3. Behara SR,
    4. Tian G,
    5. Farkas DR,
    6. Hindle M
    . Efficient nose-to-lung (N2L) aerosol delivery with a dry powder inhaler. J Aerosol Med Pulm Drug Deliv 2015;28(3):189–201.
    OpenUrl
  41. 41.↵
    1. Golshahi L,
    2. Tian G,
    3. Azimi M,
    4. Son YJ,
    5. Walenga R,
    6. Longest PW,
    7. Hindle M
    . The use of condensational growth methods for efficient drug delivery to the lungs during noninvasive ventilation high flow therapy. Pharm Res 2013;30(11):2917–2930.
    OpenUrlPubMed
  42. 42.↵
    1. Trachsel D,
    2. Hammer J
    . Indications for tracheostomy in children. Paediatr Respir Rev 2006;7(3):162–168.
    OpenUrlCrossRefPubMed
  43. 43.↵
    1. Baran D,
    2. Dachy A,
    3. Klastersky J
    . Concentration of gentamicin in bronchial secretions of children with cystic fibrosis of tracheostomy (Comparison between the intramuscular route, the endotracheal instillation and aerosolization). Int J Clin Pharmacol Biopharm 1975;12(3):336–341.
    OpenUrlPubMed
  44. 44.↵
    1. Lewis JF,
    2. McCaig L
    . Aerosolized versus instilled exogenous surfactant in a nonuniform pattern of lung injury. Am Rev Respir Dis 1993;148(5):1187–1193.
    OpenUrlPubMedWeb of Science
  45. 45.↵
    1. Berlinski A,
    2. Chavez A
    . Albuterol delivery via metered dose inhaler in a spontaneously breathing pediatric tracheostomy model. Pediatr Pulmonol 2013;48(10):1026–1034.
    OpenUrlPubMed
  46. 46.↵
    1. Berlinski A
    . Nebulized albuterol delivery in a model of spontaneously breathing children with tracheostomy. Respir Care 2013;58(12):2076–2086.
    OpenUrlAbstract/FREE Full Text
  47. 47.↵
    1. Alhamad BR,
    2. Fink JB,
    3. Harwood RJ,
    4. Sheard MM,
    5. Ari A
    . Effect of aerosol devices and administration techniques on drug delivery in a simulated spontaneously breathing pediatric tracheostomy model. Respir Care 2015;60(7):1026–1032.
    OpenUrlAbstract/FREE Full Text
  48. 48.↵
    1. Berlinski A,
    2. Cooper B
    . Oronasal and tracheostomy delivery of soft mist and pressurized metered-dose inhalers with valved holding chamber. Respir Care 2016;61(7):913–919.
    OpenUrlAbstract/FREE Full Text
  49. 49.↵
    1. Piccuito CM,
    2. Hess DR
    . Albuterol delivery via tracheostomy tube. Respir Care 2005;50(8):1071–1076.
    OpenUrlAbstract/FREE Full Text
  50. 50.↵
    1. Amirav I,
    2. Newhouse MT
    . Aerosol therapy in tracheotomized children: time for guidelines! Respir Care 2012;57(8):1350.
    OpenUrlFREE Full Text
  51. 51.↵
    1. Sherman JM,
    2. Davis S,
    3. Albamonte-Petrick S,
    4. Chatburn RL,
    5. Fitton C,
    6. Green C,
    7. et al
    . Care of the child with a chronic tracheostomy. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med 2000;161(1):297–308.
    OpenUrlCrossRefPubMedWeb of Science
  52. 52.↵
    1. Ari A,
    2. Harwood RJ,
    3. Sheard MM,
    4. Fink JB
    . An in vitro evaluation of aerosol delivery through tracheostomy and endotracheal tubes using different interfaces. Respir Care 2012;57(7):1066–1070.
    OpenUrlAbstract/FREE Full Text
  53. 53.↵
    1. Lazner MR,
    2. Basu AP,
    3. Klonin H
    . Non-invasive ventilation for severe bronchiolitis: analysis and evidence. Pediatr Pulmonol 2012;47(9):909–916.
    OpenUrlCrossRefPubMed
  54. 54.↵
    1. Amaddeo A,
    2. Moreau J,
    3. Frapin A,
    4. Khirani S,
    5. Felix O,
    6. Fernandez-Bolanos M,
    7. et al
    . Long term continuous positive airway pressure (CPAP) and noninvasive ventilation (NIV) in children: initiation criteria in real life. Pediatr Pulmonol 2016;51(9):968–974.
    OpenUrl
  55. 55.↵
    1. Sterni LM,
    2. Carroll JL
    1. Berlinski A
    . Inhaled drug delivery for children on long-term mechanical ventilation. In: Sterni LM, Carroll JL. Caring for the ventilator dependent child: a clinical guide, 1st edition. New York: Humana Press; 2016:217–239.
  56. 56.↵
    1. Brodie T,
    2. Adalat S
    . Unilateral fixed dilated pupil in a well child. Arch Dis Child 2006;91(12):961.
    OpenUrlFREE Full Text
  57. 57.↵
    1. Simonds AK,
    2. Hanak A,
    3. Chatwin M,
    4. Morrell M,
    5. Hall A,
    6. Parker KH,
    7. et al
    . Evaluation of droplet dispersion during noninvasive ventilation, oxygen therapy, nebuliser treatment and chest physiotherapy in clinical practice: implications for management of pandemic influenza and other airborne infections. Health Technol Assess 2010;14(46):131–172.
    OpenUrlPubMed
  58. 58.↵
    1. Fauroux B,
    2. Itti E,
    3. Pigeot J,
    4. Isabey D,
    5. Meignan M,
    6. Ferry G,
    7. et al
    . Optimization of aerosol deposition by pressure support in children with cystic fibrosis: an experimental and clinical study. Am J Respir Crit Care Med 2000;162(6):2265–2271.
    OpenUrlPubMed
  59. 59.↵
    1. White CC,
    2. Crotwell DN,
    3. Shen S,
    4. Salyer J,
    5. Yung D,
    6. Zheng J,
    7. DiBlasi RM
    . Bronchodilator delivery during simulated pediatric noninvasive ventilation. Respir Care 2013;58(9):1459–1466.
    OpenUrlAbstract/FREE Full Text
  60. 60.↵
    1. Velasco J,
    2. Berlinski A
    . Aerosol delivery in a pediatric model of non-invasive ventilation (abstract). Am J Respir Crit Care Med 2016;A2201.
  61. 61.↵
    1. Dai B,
    2. Kang J,
    3. Sun LF,
    4. Tan W,
    5. Zhao HW
    . Influence of exhalation valve and nebulizer position on albuterol delivery during noninvasive positive pressure ventilation. J Aerosol Med Pulm Drug Deliv 2014;27(2):125–132.
    OpenUrlPubMed
  62. 62.↵
    1. Branconnier MP,
    2. Hess DR
    . Albuterol delivery during noninvasive ventilation. Respir Care 2005;50(12):1649–1653.
    OpenUrlAbstract/FREE Full Text
  63. 63.↵
    1. Lin HL,
    2. Harwood RJ,
    3. Fink JB,
    4. Goodfellow LT,
    5. Ari A
    . In vitro comparison of aerosol delivery using different face masks and flow rates with a high-flow humidity system. Respir Care 2015;60(9):1215–1219.
    OpenUrlAbstract/FREE Full Text
  64. 64.↵
    1. Ari A,
    2. Fink JB,
    3. Dhand R
    . Inhalation therapy in patients receiving mechanical ventilation: an update. J Aerosol Med Pulm Drug Deliv 2012;25(6):319–332.
    OpenUrlPubMed
  65. 65.↵
    1. Garner SS,
    2. Wiest DB,
    3. Bradley JW,
    4. Habib DM
    . Two administration methods for inhaled salbutamol in intubated patients. Arch Dis Child 2002;87(1):49–53.
    OpenUrlAbstract/FREE Full Text
  66. 66.↵
    1. Ferrari F,
    2. Liu ZH,
    3. Lu Q,
    4. Becquemin MH,
    5. Louchahi K,
    6. Aymard G,
    7. et al
    . Comparison of lung tissue concentrations of nebulized ceftazidime in ventilated piglets: ultrasonic versus vibrating plate nebulizers. Intensive Care Med 2008;34(9):1718–1723.
    OpenUrlCrossRefPubMed
  67. 67.↵
    1. Berlinski A,
    2. Holt S,
    3. Thurman T,
    4. Heulitt M
    . Albuterol delivery during mechanical ventilation in an ex-vivo porcine model. J Aerosol Med Pulm Drug Deliv 2013;26(2):A57.
    OpenUrl
  68. 68.↵
    1. Garner SS,
    2. Wiest DB,
    3. Bradley JW
    . Albuterol delivery by metered-dose inhaler with a pediatric mechanical ventilatory circuit model. Pharmacotherapy 1994;14(2):210–214.
    OpenUrlPubMed
  69. 69.
    1. Wildhaber JH,
    2. Hayden MJ,
    3. Dore ND,
    4. Devadason SG,
    5. LeSouëf PN
    . Salbutamol delivery from a hydrofluoroalkane pressurized metered-dose inhaler in pediatric ventilator circuits: an in vitro study. Chest 1998;113(1):186–191.
    OpenUrlCrossRefPubMed
  70. 70.↵
    1. Berlinski A,
    2. Waldrep JC
    . Metering performance of several metered-dose inhalers with different spacers/holding chambers. J Aerosol Med 2001;14(4):427–432.
    OpenUrlPubMed
  71. 71.↵
    1. Diot P,
    2. Morra L,
    3. Smaldone GC
    . Albuterol delivery in a model of mechanical ventilation. Comparison of metered-dose inhaler and nebulizer efficiency. Am J Respir Crit Care Med 1995;152(4 Pt 1):1391–1394.
    OpenUrlCrossRefPubMedWeb of Science
  72. 72.↵
    1. Garner SS,
    2. Wiest DB,
    3. Bradley JW
    . Albuterol delivery by metered-dose inhaler in mechanically ventilated pediatric lung model. Crit Care Med 1996;24(5):870–874.
    OpenUrlCrossRefPubMed
  73. 73.↵
    1. Habib DM,
    2. Garner SS,
    3. Brandeburg S
    . Effect of helium-oxygen on delivery of albuterol in a pediatric, volume-cycled, ventilated lung model. Pharmacotherapy 1999;19(2):143–149.
    OpenUrlCrossRefPubMedWeb of Science
  74. 74.↵
    1. Garner SS,
    2. Wiest DB,
    3. Stevens CE,
    4. Habib DM
    . Effect of heliox on albuterol delivery by metered-dose inhaler in pediatric in vitro models of mechanical ventilation. Pharmacotherapy 2006;26(10):1396–1402.
    OpenUrlPubMed
  75. 75.↵
    1. Mitchell JP,
    2. Nagel MW,
    3. Wiersema KJ,
    4. Doyle CC,
    5. Migounov VA
    . The delivery of chlorofluorocarbon-propelled versus hydrofluoroalkane-propelled beclomethasone dipropionate aerosol to the mechanically ventilated patient: a laboratory study. Respir Care 2003;48(11):1025–1032.
    OpenUrlAbstract/FREE Full Text
  76. 76.↵
    1. Mouloudi E,
    2. Katsanoulas K,
    3. Anastasaki M,
    4. Askitopoulou E,
    5. Georgopoulos D
    . Bronchodilator delivery by metered-dose inhaler in mechanically ventilated COPD patients: influence of end-inspiratory pause. Eur Respir J 1998;12(1):165–169.
    OpenUrlAbstract
  77. 77.↵
    1. Mouloudi E,
    2. Prinianakis G,
    3. Kondili E,
    4. Georgopoulos D
    . Bronchodilator delivery by metered-dose inhaler in mechanically ventilated COPD patients: influence of flow pattern. Eur Respir J 2000;16(2):263–268.
    OpenUrlAbstract/FREE Full Text
  78. 78.↵
    1. Hanhan U,
    2. Kissoon N,
    3. Payne M,
    4. Taylor C,
    5. Murphy S,
    6. DeNicola LK
    . Effects of in-line nebulization on preset ventilator variables. Respir Care 1993;38(5):474–478.
    OpenUrl
  79. 79.↵
    1. McPeck M,
    2. O'Riordan TG,
    3. Smaldone GC
    . Choice of mechanical ventilator: influence on nebulizer performance. Respir Care 1993;38(8):887–895.
    OpenUrl
  80. 80.↵
    1. Ari A,
    2. Areabi H,
    3. Fink JB
    . Evaluation of aerosol generator devices at 3 locations in humidified and non-humidified circuits during adult mechanical ventilation. Respir Care 2010;55(7):837–844.
    OpenUrlAbstract/FREE Full Text
  81. 81.↵
    1. Di Paolo ER,
    2. Pannatier A,
    3. Cotting J
    . In vitro evaluation of bronchodilator drug delivery by jet nebulization during pediatric mechanical ventilation. Pediatr Crit Care Med 2005;6(4):462–469.
    OpenUrlPubMed
  82. 82.↵
    1. Ari A,
    2. Atalay OT,
    3. Harwood R,
    4. Sheard MM,
    5. Aljamhan EA,
    6. Fink JB
    . Influence of nebulizer type, position, and bias flow on aerosol drug delivery in simulated pediatric and adult lung models during mechanical ventilation. Respir Care 2010;55(7):845–851.
    OpenUrlAbstract/FREE Full Text
  83. 83.↵
    1. Berlinski A,
    2. Willis JR
    . Albuterol delivery via intrapulmonary percussive ventilator and jet nebulizer in a pediatric ventilator model. Respir Care 2010;55(12):1699–1704.
    OpenUrlAbstract/FREE Full Text
  84. 84.↵
    1. Berlinski A,
    2. Willis JR
    . Albuterol delivery by 4 different nebulizers placed in 4 different positions in a pediatric ventilator in vitro model. Respir Care 2013;58(7):1124–1133.
    OpenUrlAbstract/FREE Full Text
  85. 85.↵
    1. Sidler-Moix AL,
    2. Dolci U,
    3. Berger-Gryllaki M,
    4. Pannatier A,
    5. Cotting J,
    6. Di Paolo ER
    . Albuterol delivery in an in vitro pediatric ventilator lung model: comparison of jet, ultrasonic, and mesh nebulizers. Pediatr Crit Care Med 2013;14(2):e98–e102.
    OpenUrlPubMed
  86. 86.↵
    1. Wan GH,
    2. Lin HL,
    3. Fink JB,
    4. Chen YH,
    5. Wang WJ,
    6. Chiu YC,
    7. et al
    . In vitro evaluation of aerosol delivery by different nebulization modes in pediatric and adult mechanical ventilators. Respir Care 2014;59(10):1494–500.
    OpenUrlAbstract/FREE Full Text
  87. 87.↵
    1. Berlinski A,
    2. Willis JR
    . Effect of tidal volume and nebulizer type and position on albuterol delivery in a pediatric model of mechanical ventilation. Respir Care 2015;60(10):1424–1430.
    OpenUrlAbstract/FREE Full Text
  88. 88.↵
    1. Ahrens RC,
    2. Ries RA,
    3. Popendorf W,
    4. Wiese JA
    . The delivery of therapeutic aerosols through endotracheal tubes. Pediatr Pulmonol 1986;2(1):19–26.
    OpenUrlPubMedWeb of Science
  89. 89.↵
    1. Berlinski A,
    2. Kumaran S
    . Particle size characterization of nebulized albuterol delivered by a vibrating mesh nebulizer through pediatric endotracheal tubes (abstract). Am J Respir Crit Care Med 2016;A2191.
  90. 90.↵
    1. Fang TP,
    2. Lin HL,
    3. Chiu SH,
    4. Wang SH,
    5. DiBlasi RM,
    6. Tsai YH,
    7. Fink JB
    . Aerosol delivery using jet nebulizer and vibrating mesh nebulizer during high frequency oscillatory ventilation: an in vitro comparison. J Aerosol Med Pulm Drug Deliv 2016;29(5):447–453.
    OpenUrl
  91. 91.↵
    1. Longest PW,
    2. Tian G
    . Development of a new technique for the efficient delivery of aerosolized medications to infants on mechanical ventilation. Pharm Res 2015;32(1):321–336.
    OpenUrlPubMed
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Respiratory Care: 62 (6)
Respiratory Care
Vol. 62, Issue 6
1 Jun 2017
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Pediatric Aerosol Therapy
Ariel Berlinski
Respiratory Care Jun 2017, 62 (6) 662-677; DOI: 10.4187/respcare.05298

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Pediatric Aerosol Therapy
Ariel Berlinski
Respiratory Care Jun 2017, 62 (6) 662-677; DOI: 10.4187/respcare.05298
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  • Article
    • Abstract
    • Introduction
    • Delivery Device Selection for the Treatment of Acute Pediatric Asthma
    • Transnasal Aerosol Delivery in Pediatric Patients
    • Delivery Device Selection for Spontaneously Breathing Tracheostomized Children
    • Delivery Device Selection for Pediatric Patients Receiving NIV
    • Delivery Device Selection for Mechanically Ventilated Pediatric Patients
    • Summary
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Keywords

  • nasal cannula
  • noninvasive ventilation
  • NIV
  • nebulizer
  • metered dose inhaler
  • nasal delivery
  • Children
  • valved holding chamber
  • HFNC
  • albuterol
  • mechanical ventilation

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