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EditorialEditor's Choice

Effect of Interval Between Actuations of Albuterol Hydrofluoroalkane Pressurized Metered-Dose Inhalers on Their Aerosol Characteristics

Ariel Berlinski and David Pennington
Respiratory Care September 2017, 62 (9) 1123-1130; DOI: https://doi.org/10.4187/respcare.05528
Ariel Berlinski
University of Arkansas for Medical Sciences, College of Medicine.
Pediatric Pulmonology Division, UAMS, and the Pediatric Aerosol Research Laboratory, Arkansas Children's Research Institute, Little Rock, Arkansas.
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  • For correspondence: [email protected]
David Pennington
University of Arkansas for Medical Sciences, College of Medicine.
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References

  1. 1.↵
    Centers for Disease Control and Prevention. Most Recent Asthma Data. http://www.cdc.gov/asthma/most_recent_data.htm. Accessed April 25, 2017.
  2. 2.↵
    National Institutes of Health. National Heart, Lung, and Blood Institute. National Asthma Education and Prevention Program. Expert Panel Report 3: guidelines for the diagnosis and management of asthma. Aug 2007. NIH publication no. 07-4051. http://www.nhlbi.nih.gov/guidelines/asthma/index.htm. Accessed December 30, 2015.
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    VentolinR HFA package insert. Highlights of prescribing information. Philadelphia, Pennsylvania: GlaxoSmithKline; June 2009.
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    ProAirR HFA package insert. Highlights of prescribing information. Horsham, Pennsylvania: Teva Respiratory; Revised July 2010.
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    ProventilR HFA package insert. Prescribing information. Kenilworth, New Jersey: Schering-Plough Corporation; Revised November 2010.
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    7. et al
    . Effect of time between actuation on the dose variability for three metered dose inhalers. Respir Drug Deliv Eur 2013;2:429–434.
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    1. Clark DJ,
    2. Lipworth BJ
    . Effect of multiple actuations, delayed inhalation and antistatic treatment on the lung bioavailability of salbutamol via a spacer device. Thorax 1996;51(10):981–984.
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  9. 9.↵
    1. McCabe JC,
    2. Koppenhagen F,
    3. Blair J,
    4. Zeng XM
    . ProAir HFA delivers warmer, lower-impact, longer-duration plumes containing higher fine particle dose than Ventolin HFA. J Aerosol Med and Pulm Drug Deliv 2012;25(2):104–109.
    OpenUrl
  10. 10.↵
    1. Marple VA,
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    . Next generation pharmaceutical impactor (a new impactor for pharmaceutical inhaler testing). Part II: Archival calibration. J Aerosol Med 2003;16(3):301–324.
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  11. 11.↵
    1. Kelly HW,
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  12. 12.↵
    1. Slator L,
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    . In vitro comparison of the effect of inhalation delay and flow rate on the emitted dose from three valved holding chambers. J Aerosol Med Pulm Drug Deliv 2014;27 Suppl 1:S37–S43.
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    . The importance of nonelectrostatic materials in holding chambers for delivery of hydrofluoroalkane albuterol. Respir Care 2006;51(5):503–510.
    OpenUrlAbstract/FREE Full Text
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Respiratory Care: 62 (9)
Respiratory Care
Vol. 62, Issue 9
1 Sep 2017
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Effect of Interval Between Actuations of Albuterol Hydrofluoroalkane Pressurized Metered-Dose Inhalers on Their Aerosol Characteristics
Ariel Berlinski, David Pennington
Respiratory Care Sep 2017, 62 (9) 1123-1130; DOI: 10.4187/respcare.05528

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Effect of Interval Between Actuations of Albuterol Hydrofluoroalkane Pressurized Metered-Dose Inhalers on Their Aerosol Characteristics
Ariel Berlinski, David Pennington
Respiratory Care Sep 2017, 62 (9) 1123-1130; DOI: 10.4187/respcare.05528
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Keywords

  • drug delivery
  • aerosol characteristics
  • valved holding chamber
  • metered dose inhaler
  • particle size
  • delay

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