Skip to main content
 

Main menu

  • Home
  • Content
    • Current Issue
    • Editor's Commentary
    • Archives
    • Most-Read Papers of 2022
  • Authors
    • Author Guidelines
    • Submit a Manuscript
  • Reviewers
    • Reviewer Information
    • Create Reviewer Account
    • Reviewer Guidelines: Original Research
    • Reviewer Guidelines: Reviews
    • Appreciation of Reviewers
  • CRCE
    • Through the Journal
    • JournalCasts
    • AARC University
    • PowerPoint Template
  • Open Forum
    • 2023 Call for Abstracts
    • 2022 Abstracts
    • Previous Open Forums
  • Podcast
    • English
    • Español
    • Portugûes
    • 国语
  • Videos
    • Video Abstracts
    • Author Interviews
    • Highlighted Articles
    • The Journal

User menu

  • Subscribe
  • My alerts
  • Log in

Search

  • Advanced search
American Association for Respiratory Care
  • Subscribe
  • My alerts
  • Log in
American Association for Respiratory Care

Advanced Search

  • Home
  • Content
    • Current Issue
    • Editor's Commentary
    • Archives
    • Most-Read Papers of 2022
  • Authors
    • Author Guidelines
    • Submit a Manuscript
  • Reviewers
    • Reviewer Information
    • Create Reviewer Account
    • Reviewer Guidelines: Original Research
    • Reviewer Guidelines: Reviews
    • Appreciation of Reviewers
  • CRCE
    • Through the Journal
    • JournalCasts
    • AARC University
    • PowerPoint Template
  • Open Forum
    • 2023 Call for Abstracts
    • 2022 Abstracts
    • Previous Open Forums
  • Podcast
    • English
    • Español
    • Portugûes
    • 国语
  • Videos
    • Video Abstracts
    • Author Interviews
    • Highlighted Articles
    • The Journal
  • Twitter
  • Facebook
  • YouTube
Research ArticleConference Proceedings

Clinical Pharmacology of Corticosteroids

Dennis M Williams
Respiratory Care June 2018, 63 (6) 655-670; DOI: https://doi.org/10.4187/respcare.06314
Dennis M Williams
Division of Pharmacotherapy and Experimental Therapeutic, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
  • Article
  • Figures & Data
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Gupta P,
    2. Bhatia V
    . Corticosteroid physiology and principles of therapy. Indian J Pediatr 2008;75(10):1039–1044.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Shaikh S,
    2. Verma H,
    3. Yadav M,
    4. Jauhari M,
    5. Bullangowda J
    , Applications of steroid in clinical practice: a review. ISRN Anesthesiol 2012, vol. 2012, Article ID 985495, 11 pages, 2012. doi:10.5402/2012/985495.
    OpenUrlCrossRef
  3. 3.↵
    1. Becker DE
    . Basic and clinical pharmacology of glucocorticosteroids. Anesth Prog 2013;60(1):25–31; quiz 32.
    OpenUrl
  4. 4.↵
    1. Annane D
    . Adrenal insufficiency in sepsis. Curr Pharm Des 2008;14(19):1882–1886.
    OpenUrlCrossRefPubMedWeb of Science
  5. 5.↵
    1. Taylor DR,
    2. Hancox RJ
    . Interactions between corticosteroids and beta agonists. Thorax 2000;55:595–602.
    OpenUrlFREE Full Text
  6. 6.↵
    1. Derendorf H,
    2. Nave R,
    3. Drollmann A,
    4. Cerasoli F,
    5. Wurst W
    . Relevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthma. Eur Respir J 2006;28(5):1042–1050.
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. Raissy HH,
    2. Kelly HW,
    3. Harkins M,
    4. Szefler SJ
    . Inhaled corticosteroids in lung diseases. Am J Respir Crit Care Med 2013;187(8):798–803.
    OpenUrlCrossRefPubMed
  8. 8.↵
    1. Barnes PJ
    . How Do Corticosteroids Work in Asthma? Ann Intern Med 2003;139(5 Pt 1):359–370.
    OpenUrlCrossRefPubMedWeb of Science
  9. 9.↵
    1. Ye Q,
    2. He XO,
    3. D'Urzo A
    . A review on the safety and efficacy of inhaled corticosteroids in the management of asthma. Pulm Ther 2017;3(1):1–18.
    OpenUrl
  10. 10.↵
    1. Ericson-Neilsen W,
    2. Kaye AD
    . Steroids: pharmacology, complications, and practice delivery issues. Ochsner J 2014;14(2):203–207.
    OpenUrl
  11. 11.↵
    1. Moss GP
    . Nomenclature of steroids. Pure Appl Chem 1989;61(10):1783–1822.
    OpenUrl
  12. 12.↵
    1. Daley-Yates PT
    . Inhaled corticosteroids: potency, dose equivalence and therapeutic index. Br J Clin Pharmacol 2015;80(3):372–380.
    OpenUrl
  13. 13.↵
    1. Swartz SL,
    2. Dluhy RG
    . Corticosteroids: clinical pharmacology and therapeutic use. Drugs 1978;16(3):238–255.
    OpenUrlCrossRefPubMedWeb of Science
  14. 14.↵
    1. Liu D,
    2. Ahmet A,
    3. Ward L,
    4. Krishnamoorthy P,
    5. Mandelcorn ED,
    6. Leigh R,
    7. et al
    . A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. Allergy Asthma Clin Immunol 2013;9(1):30–37.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Waljee AK,
    2. Rogers MA,
    3. Lin P,
    4. Singal AG,
    5. Stein JD,
    6. Marks RM,
    7. et al
    . Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study. BMJ 2017;357:j1415.
    OpenUrlAbstract/FREE Full Text
  16. 16.↵
    1. Lipworth BJ
    . Clinical pharmacology of corticosteroids in bronchial asthma. Pharmacol Ther 1993;58(2):173–209.
    OpenUrlCrossRefPubMedWeb of Science
  17. 17.↵
    National Institute for Health and Care Excellence (2017). List of Drug Interactions: Corticosteroids. Evidence Search. Accessed 16 May 2017.
  18. 18.↵
    1. Johnson M
    . Development of fluticasone propionate and comparison with other inhaled corticosteroids. J Allergy Clin Immunol 1998;101(4 Pt 2):S434–S439.
    OpenUrlCrossRefPubMedWeb of Science
  19. 19.↵
    1. Dalby RN,
    2. Byron PR,
    3. Peart J,
    4. Farr SJ
    1. Brattsand R
    . Development of inhaled steroids: past, present and prospects. In: Dalby RN, Byron PR, Peart J, Farr SJ, editors. Respiratory Drug Delivery. Richmond, VA: Virginia Commonwealth University; 2002:1–14.
  20. 20.↵
    1. Phillips K,
    2. Oborne J,
    3. Lewis S,
    4. Harrison TW,
    5. Tattersfield AE
    . Time course of action of two inhaled corticosteroids, fluticasone propionate and budesonide. Thorax 2004;59(1):26–30.
    OpenUrlAbstract/FREE Full Text
  21. 21.↵
    1. Yeo SH,
    2. Aggarwal B,
    3. Shantakumar S,
    4. Mulgirigama A,
    5. Daley-Yates P
    . Efficacy and safety of inhaled corticosteroids relative to fluticasone propionate: a systematic review of randomized controlled trials in asthma. Expert Rev Respir Med 2017;11(10):763–778.
    OpenUrl
  22. 22.↵
    1. Thorsson L,
    2. Edsbäcker S,
    3. Conradson TB
    . Lung deposition of budesonide from Turbuhaler is twice that from a pressurized metered-dose inhaler P-MDI. Eur Respir J 1994;7(10):1839–1844.
    OpenUrlAbstract
  23. 23.↵
    1. van der Molen T,
    2. Kocks JW
    . The efficacy and safety of inhaled corticosteroids: are we ignoring the potential advantages of ciclesonide? NPJ Prim Care Respir Med 2014;24:14013.
    OpenUrl
  24. 24.↵
    1. Kramer S,
    2. Rottier BL,
    3. Scholten RJ,
    4. Boluyt N
    . Ciclesonide versus other inhaled corticosteroids for chronic asthma in children. Cochrane Database Syst Rev 2013;(2):CD010352.
  25. 25.↵
    1. Derendorf H,
    2. Hochhaus G,
    3. Meibohm B,
    4. Möllmann H,
    5. Barth J
    . Pharmacokinetics and pharmacodynamics of inhaled corticosteroids. J Allergy Clin Immunol 1998;101(4 Pt 2):S440–S446.
    OpenUrlCrossRefPubMedWeb of Science
  26. 26.↵
    1. Sobande PO,
    2. Kercsmar CM
    . Inhaled corticosteroids in asthma management. Respir Care 2008;53(5):625–633; discussion 633-634.
    OpenUrlAbstract/FREE Full Text
  27. 27.↵
    1. García-Arieta A
    . Sensitive studies with a significant dose-response curve for inhaled corticosteroids to investigate equivalent relative potency are feasible. Br J Clin Pharmacol 2011;72(5):832–833; author reply 834-835.
    OpenUrlPubMed
  28. 28.↵
    1. Colice GL
    . Comparing inhaled corticosteroids. Respir Care 2000;45(7):846–853.
    OpenUrlPubMed
  29. 29.↵
    1. Kelly HW
    . Comparison of inhaled corticosteroids: an update. Ann Pharmacother 2009;43(3):519–527.
    OpenUrlCrossRefPubMed
  30. 30.↵
    1. Zitt MJ
    . Advances in inhaled corticosteroid pharmacology. Allergy Asthma Proc 2007;28(2):114–124.
    OpenUrlCrossRefPubMedWeb of Science
  31. 31.↵
    1. Geddes DM
    . Inhaled corticosteroids: benefits and risks. Thorax 1992;47(6):404–407.
    OpenUrlFREE Full Text
  32. 32.↵
    1. Currie GP,
    2. Fowler SJ,
    3. Lipworth BJ
    . Dose response of inhaled corticosteroids on bronchial hyperresponsiveness: a meta-analysis. Ann Allergy Asthma Immunol 2003;90(2):194–198.
    OpenUrlCrossRefPubMedWeb of Science
  33. 33.↵
    1. Martin RJ,
    2. Szefler SJ,
    3. Chinchilli VM,
    4. Kraft M,
    5. Dolovich M,
    6. Boushey HA,
    7. et al
    . Systemic effect comparisons of six inhaled corticosteroid preparations. Am J Respir Crit Care Med 2002;165(10):1377–1383.
    OpenUrlCrossRefPubMedWeb of Science
  34. 34.↵
    1. Kelly HW,
    2. Sternberg AL,
    3. Lescher R,
    4. Fuhlbrigge AL,
    5. Williams P,
    6. Zeiger RS,
    7. et al
    ; CAMP Research Goup. Effect of inhaled glucocorticoids in childhood on adult height. N Engl J Med 2012;367(10):904–912.
    OpenUrlCrossRefPubMedWeb of Science
  35. 35.↵
    1. Loke YK,
    2. Blanco P,
    3. Thavarajah M,
    4. Wilson AM
    . Impact of inhaled corticosteroids on growth in children with asthma: Systematic review and meta-analysis. PLoS One 2015;10(7):e0133428.
    OpenUrl
  36. 36.↵
    1. Bourbeau J,
    2. Aaron SD,
    3. Barnes NC,
    4. Davis KJ,
    5. Lacasse Y,
    6. Nadeau G
    . Evaluating the risk of pneumonia with inhaled corticosteroids in COPD: Retrospective database studies have their limitations SA. Respir Med 2017;123:94–97.
    OpenUrl
  37. 37.↵
    1. Suissa S,
    2. Patenaude V,
    3. Lapi F,
    4. Ernst P
    . Inhaled corticosteroids in COPD and the risk of serious pneumonia. Thorax 2013;68(11):1029–1036.
    OpenUrlAbstract/FREE Full Text
  38. 38.↵
    1. Kew KM,
    2. Seniukovich A
    . Inhaled steroids and risk of pneumonia for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2014;(3):CD010115.
  39. 39.↵
    1. Qian CJ,
    2. Coulombe J,
    3. Suissa S,
    4. Ernst P
    . Pneumonia risk in asthma patients using inhaled corticosteroids: a quasi-cohort study. Br J Clin Pharmacol 2017;83(9):2077–2086.
    OpenUrl
  40. 40.↵
    1. Saberi P,
    2. Phengrasamy T,
    3. Nguyen DP
    . Inhaled corticosteroid use in HIV-positive individuals taking protease inhibitors: a review of pharmacokinetics, case reports and clinical management. HIV Med 2013;14(9):519–529.
    OpenUrlCrossRefPubMed
  41. 41.↵
    1. Drummond MB,
    2. Kunisaki KM,
    3. Huang L
    . Obstructive lung diseases in HIV: A clinical review and identification of key future research needs. Semin Respir Crit Care Med 2016;37(2):277–288.
    OpenUrlCrossRefPubMed
  42. 42.↵
    1. Daveluy A,
    2. Raignoux C,
    3. Miremont-Salamé G,
    4. Girodet PO,
    5. Moore N,
    6. Haramburu F,
    7. Molimard M
    . Drug interactions between inhaled corticosteroids and enzymatic inhibitors. Eur J Clin Pharmacol 2009;65(7):743–745.
    OpenUrlCrossRefPubMed
  43. 43.↵
    GOLD Science Committee. Global Initiative for Chronic Obstructive Lung Disease. 2018 ed. Global Initiative for Chronic Obstructive Lung Disease, Inc; 2018. http://copdgold.org. Accessed December 31, 2017.
  44. 44.↵
    1. Babu KS,
    2. Kastelik JA,
    3. Morjaria JB
    . Inhaled corticosteroids in chronic obstructive pulmonary disease: a pro-con perspective. Br J Clin Pharmacol 2014;78(2):282–300.
    OpenUrl
  45. 45.↵
    1. Leuppi JD,
    2. Schuetz P,
    3. Bingisser R,
    4. Bodmer M,
    5. Briel M,
    6. Drescher T,
    7. et al
    . Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial. JAMA 2013;309(21):2223–2231.
    OpenUrlCrossRefPubMedWeb of Science
PreviousNext
Back to top

In this issue

Respiratory Care: 63 (6)
Respiratory Care
Vol. 63, Issue 6
1 Jun 2018
  • Table of Contents
  • Table of Contents (PDF)
  • Cover (PDF)
  • Index by author

 

Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on American Association for Respiratory Care.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Clinical Pharmacology of Corticosteroids
(Your Name) has sent you a message from American Association for Respiratory Care
(Your Name) thought you would like to see the American Association for Respiratory Care web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Clinical Pharmacology of Corticosteroids
Dennis M Williams
Respiratory Care Jun 2018, 63 (6) 655-670; DOI: 10.4187/respcare.06314

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Clinical Pharmacology of Corticosteroids
Dennis M Williams
Respiratory Care Jun 2018, 63 (6) 655-670; DOI: 10.4187/respcare.06314
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Hypothalamic-Pituitary-Adrenal Axis Physiology
    • Glucocorticoids
    • Agents for Systemic Therapy
    • Inhaled Corticosteroids
    • Clinical Applications in Lung Disease
    • Summary
    • Discussion
    • Footnotes
    • References
    • References
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

Related Articles

Cited By...

Keywords

  • COPD
  • asthma corticosteroids
  • lung disease

Info For

  • Subscribers
  • Institutions
  • Advertisers

About Us

  • About the Journal
  • Editorial Board

AARC

  • Membership
  • Meetings
  • Clinical Practice Guidelines

More

  • Contact Us
  • RSS
American Association for Respiratory Care

Print ISSN: 0020-1324        Online ISSN: 1943-3654

© Daedalus Enterprises, Inc.

Powered by HighWire