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Research ArticleOriginal Research

Aerosol Delivery Through an Adult High-Flow Nasal Cannula Circuit Using Low-Flow Oxygen

Yasmin M Madney, Maha Fathy, Ahmed A Elberry, Hoda Rabea and Mohamed EA Abdelrahim
Respiratory Care April 2019, 64 (4) 453-461; DOI: https://doi.org/10.4187/respcare.06345
Yasmin M Madney
Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
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Maha Fathy
Respiratory Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
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Ahmed A Elberry
Clinical Pharmacology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
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Hoda Rabea
Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
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Mohamed EA Abdelrahim
Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Clinical Pharmacy Department, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt.
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    Fig. 1.

    Schematic design of an in vivo setting showing the positions of the aerosol generator within the high-flow nasal cannula circuit and measurement of urinary salbutamol excretion. RH = relative humidity.

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    Fig. 2.

    Assembly of aerosol generators with its connections. VMN = vibrating mesh nebulizer; pMDI = pressurized metered-dose inhaler.

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    Fig. 3.

    Schematic design of ex vivo setting, showing the positions of the aerosol generator and the ex vivo filter within the high-flow nasal cannula circuit. RH = relative humidity.

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    Fig. 4.

    Percentage of the urinary salbutamol amount (mean ± SD) excreted 30 min after dosing by a different aerosol generator. VMN = vibrating mesh nebulizer.

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    Fig. 5.

    Percentage of the urinary salbutamol amount (mean ± SD) pooled at 24 h after dosing by a different aerosol generator. VMN = vibrating mesh nebulizer.

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    Fig. 6.

    Percentage of the salbutamol amount (mean ± SD) deposited on the ex vivo filter (% aerosol emitted) by different aerosol generator. VMN = vibrating mesh nebulizer.

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Respiratory Care: 64 (4)
Respiratory Care
Vol. 64, Issue 4
1 Apr 2019
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Aerosol Delivery Through an Adult High-Flow Nasal Cannula Circuit Using Low-Flow Oxygen
Yasmin M Madney, Maha Fathy, Ahmed A Elberry, Hoda Rabea, Mohamed EA Abdelrahim
Respiratory Care Apr 2019, 64 (4) 453-461; DOI: 10.4187/respcare.06345

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Aerosol Delivery Through an Adult High-Flow Nasal Cannula Circuit Using Low-Flow Oxygen
Yasmin M Madney, Maha Fathy, Ahmed A Elberry, Hoda Rabea, Mohamed EA Abdelrahim
Respiratory Care Apr 2019, 64 (4) 453-461; DOI: 10.4187/respcare.06345
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Keywords

  • nebulizers
  • large spacer
  • HFNC
  • inhalation therapy
  • nasal cannula
  • low-flow oxygen

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