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Research ArticleOriginal Research

Dead Space to Tidal Volume Ratio Is Associated With Higher Postextubation Support in Children

Jonathan A Gehlbach, Andrew G Miller, Christoph P Hornik and Ira M Cheifetz
Respiratory Care November 2020, 65 (11) 1721-1729; DOI: https://doi.org/10.4187/respcare.07351
Jonathan A Gehlbach
Department of Pediatrics, Division of Pediatric Critical Care Medicine, The University of Illinois College of Medicine, Peoria, Illinois.
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  • For correspondence: [email protected]
Andrew G Miller
Respiratory Care Services, Duke University Medical Center, Durham, North Carolina.
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Christoph P Hornik
Department of Pediatrics, Division of Pediatric Critical Care Medicine, Duke Children’s Hospital, Durham, North Carolina.
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Ira M Cheifetz
Respiratory Care Services, Duke University Medical Center, Durham, North Carolina.
Department of Pediatrics, Division of Pediatric Critical Care Medicine, Duke Children’s Hospital, Durham, North Carolina.
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Abstract

BACKGROUND: Extubation failure is associated with increased duration of mechanical ventilation, length of hospital stay, and mortality. An elevated dead-space-to-tidal-volume ratio (VD/VT) has been proposed as a predictor of successful extubation in children. We hypothesized that a higher VD/VT value would be associated with extubation failure and higher postextubation respiratory support.

METHODS: This was a prospective, observational, cohort study. All subjects were < 18 y old and were extubated in the pediatric multidisciplinary ICU or the cardiac ICU at an academic medical center from June 2016 through March 2017. Using arterial blood gas analysis and mainstream volumetric capnography, daily VD/VT measurements were obtained on intubated subjects using an automated algorithm. Respiratory support upon extubation was based on the clinical team’s judgment and defined as low (ie, room air or nasal cannula) or high (ie, high-flow nasal cannula, CPAP, or bi-level positive airway pressure). Subjects were monitored for 48 h after extubation for escalation in respiratory support and need for re-intubation.

RESULTS: Of 189 subjects included in the analysis, 166 were successfully extubated and 23 (12%) required re-intubation. There was no significant difference in final VD/VT between those who extubated successfully and those who failed extubation, with a median VD/VT of 0.28 (interquartile range [IQR] 0.20–0.37) vs 0.29 (IQR 0.21–0.33), respectively (P = .87). Those who received a high level of support upon extubation had a higher VD/VT than those who received a low level of support, with a median of 0.32 (IQR 0.23–0.39) vs 0.25 (IQR 0.16–0.30), respectively (P < .001). This association remained significant when controlling for age, duration of intubation, and cyanotic congenital heart disease (odds ratio 1.63, 95% CI 1.18–2.24).

CONCLUSIONS: There was no significant relationship between VD/VT and extubation success, although VD/VT was associated with the level of respiratory support provided following extubation. Further studies should investigate whether the use of VD/VT can help reduce extubation failure rates with varying levels of postextubation respiratory support.

  • dead space
  • respiratory failure
  • extubation readiness
  • mechanical ventilation
  • critical care
  • pediatric
  • gas exchange

Introduction

Extubation failure occurs in 4–14% of mechanically ventilated pediatric patients.1-7 The need for re-intubation has been associated with increased duration of mechanical ventilation, length of hospital and ICU stay, and mortality.2,4,6 Currently, there is no one tool that reliably predicts successful extubation in children. Validated extubation tools that quantify pulmonary disease may help reduce the incidence of failed extubation and thus may limit morbidity and potentially mortality. Furthermore, improved ability to predict those at risk for extubation failure may influence the choice of postextubation respiratory support.

One such proposed tool is the ratio of dead space to tidal volume (VD/VT). Physiologic dead space represents the portion of the respiratory tract that does not participate in gas exchange. Normal VD/VT ranges from 0.25 to 0.4, whereas VD/VT > 0.4 (ie, more dead space) suggests pulmonary pathology. A quantitative assessment of physiologic dead space, VD/VT has been reported to have utility in predicting extubation failure in adults,8,9 as well as prognosticating in ARDS10-13 and measuring the impact of bronchodilators in COPD.14 In children, VD/VT has been used as a marker of severity of lung disease15,16 and as a method to trend gas exchange in the lungs of neonates requiring extracorporeal membranous oxygenation,17 and it is associated with prolonged duration of mechanical ventilation.18 VD/VT has been studied as a predictor of successful extubation in children with mixed results. Hubble et al19 and Riou et al20 each reported that a higher VD/VT (> 0.65 and > 0.55, respectively) was associated with extubation failure, whereas Bousso et al21 failed to find such an association. Of these, only the study by Riou et al20 was published within the past 10 y, during which time there have been significant advancements in respiratory management in the ICU. More recently, Devor et al22 noted an association between extubation failure and VD/VT > 0.5 in children who underwent cardiac surgery with 2-ventricle repair, but not in those with single-ventricle physiology.

The purpose of this study was to add to the existing literature on VD/VT as a potential risk factor for extubation failure in children after the widespread adoption of noninvasive respiratory support in the ICU. Most studies to date were published prior to the introduction and adoption of high-flow nasal cannula (HFNC) and noninvasive ventilation. We hypothesized that elevated VD/VT would be associated with risk for extubation failure. We also hypothesized, as a secondary outcome, that VD/VT would be associated with the need for a higher level of postextubation respiratory support.

Quick Look

Current Knowledge

The dead space to tidal volume ratio (VD/VT) is a quantitative measurement of respiratory dead space and has been reported to have prognostic value in a variety of disease states. In pediatrics, there have been 3 prior studies that yielded conflicting results when evaluating the association between VD/VT and extubation success, and only one of these studies was performed within the past 10 years.

What This Paper Contributes to Our Knowledge

This prospective, observational, cohort analysis is the largest clinical study to date to evaluate the association between VD/VT and extubation success. VD/VT was associated with the level of respiratory support provided immediately following extubation.

Methods

The Institutional Review Board at Duke University Medical Center approved this study, including a waiver of informed consent. We prospectively enrolled consecutive, invasively ventilated children < 18 y old who were extubated in the pediatric multidisciplinary ICU and cardiac ICU at Duke Children’s Hospital in Durham, North Carolina, from June 2016 through March 2017. We collected data using a combination of the electronic health record and a bedside data-collection sheet. Patients were excluded if they were extubated as part of withdrawal of life-sustaining care, received a tracheostomy at the time of extubation, or did not have an arterial blood gas (ABG) drawn within 12 h prior to extubation (ie, Embedded Image is required to determine VD/VT). We did not exclude patients on the basis of their disease processes. Subjects with multiple episodes of invasive ventilation were considered individually for each episode of extubation.

While receiving mechanical ventilation, subjects were managed with a respiratory therapist-driven mechanical ventilation protocol that included daily extubation readiness trials (ERT) in accordance with our institutional practice (see supplementary material at http://www.rcjournal.com). All children received invasive ventilation with AVEA ventilators (CareFusion, San Diego, California) while on conventional ventilator support, and all had heated humidifiers included in the ventilator circuit. To be considered for extubation, subjects had to pass an ERT, which consisted of 60–90 min of pressure support ventilation. The amount of pressure support provided (ie, 10 cm H2O for 3.0–3.5-mm tubes, 8 cm H2O for 4.0–4.5-mm tubes, and 6 cm H2O for tubes ≥ 5.0 mm) was set based on the size of the child.23 Subjects were considered to have failed their ERT if they developed one or more of the following: tachypnea (ie, breathing frequency > 60 breaths/min for those < 6 months old, breathing frequency > 45 breaths/min for those 6–24 months old, breathing frequency > 40 breaths/min for those who were 25–60 months old, or breathing frequency > 35 breaths/min for older children), VT < 5 mL/kg, or hypoxemia requiring Embedded Image > 0.5. Additional findings, such as unexplained tachycardia during the ERT, were subjectively considered by the clinical team when deciding whether to proceed with extubation. Extubation was considered appropriate if the following conditions were met: passed ERT with adequate gas exchange, minimal sedation requirements, presence of cough and gag reflexes, and the presence of a leak around the endotracheal tube with the cuff deflated. The absence of a leak was not a contraindication to extubation, as routine practice in these instances is to proceed with extubation while administering 24–48 h of systemic corticosteroids to treat airway inflammation. The mechanical ventilation protocol used at our institution suggested an additional extubation criterion of VD/VT < 0.6, although the procedure also states that extubation could be considered at higher values (eg, if noninvasive ventilation was to be used after extubation). The ultimate decision to extubate was made at the discretion of the attending physician in conjunction with the clinical team.

Following extubation, clinical management continued according to standard practice. Support at extubation was determined by the care team under the supervision of the attending physician and was based on various factors such as radiographic evidence of disease, anticipated work of breathing after extubation, Embedded Image , baseline chronic lung disease, and duration of intubation. Because this was an observational study, we did not prescribe a formal protocol for respiratory support following extubation. HFNC was managed by the provider team, and CPAP and bi-level positive airway pressure (BPAP) were managed per the respiratory therapist-driven protocol, although transition from one mode to another required discussion with a physician or advanced practice nurse practitioner. The decision to escalate support was based on the clinical care team’s assessment of work of breathing (eg, tachypnea, nasal flaring, accessory muscle use), hypoxemia, hypoventilation, or hemodynamic instability.

he primary end point for this study was extubation success, defined as avoiding re-intubation for 48 h after extubation. Secondary end points were planned support on extubation and escalation in support within 48 h after extubation. Low support was defined a priori as room air (ie, no respiratory support) or nasal cannula, whereas high support was defined as HFNC (defined as flow titrated to meet subjects’ inspiratory demand and the Embedded Image goal per clinical policy), CPAP, or BPAP. Escalation in support was defined as re-intubation, transition from low to high support, or from HFNC to CPAP or BPAP. Use of a helium-oxygen mixture for postextubation stridor was not tracked as part of this study.

Data Collection

We collected demographic data on each subject, including age, gender, race, diagnosis, ICU in which the subject was extubated, and duration of invasive ventilation prior to extubation. Age was recorded in years, rounded to the nearest month for those < 2 y old. We categorized indications for invasive ventilation as pulmonary disease, cardiovascular disease, hemodynamic instability, operative/procedural, neurologic impairment, or upper-airway obstruction (including stridor). The same categorizations were used to stratify cause of extubation failure. Subjects were not limited to a single indication (eg, a subject who remained intubated postoperatively for a single-ventricle palliation procedure would have been included in the cardiovascular disease and operative/procedural groups). We also noted presence of baseline pulmonary disease and cyanotic congenital heart disease, when present.

Per standard clinical practice, daily (at minimum) VD/VT measurements were obtained with each morning ABG, excluding days in which subjects required extracorporeal membranous oxygenation or high-frequency ventilation. Additional VD/VT measurements were obtained at the discretion of the clinical team. For each VD/VT recorded, we documented the ventilator settings at the time the ABG was obtained: ventilator mode, set frequency, total peak inspiratory pressure, PEEP, pressure support, and Embedded Image . Per unit policy, targeted exhaled VT was 5–8 mL/kg of ideal body weight.

Respironics NM3 respiratory monitors (Philips Healthcare, Eindhoven, Netherlands) were used to calculate VD/VT values. The monitors utilize mainstream capnography at the endotracheal tube Y-piece to measure single-breath, real-time, mixed, expired CO2 concentration (Embedded Image ), so named because it represents the concentration of CO2 exhaled from a mixture of large airways (physiologic dead space) and alveolar space. The monitors then use the subject’s Embedded Image (obtained via ABG and manually entered into the monitor) to calculate the VD/VT using the Enghoff modification of the Bohr equation: (Embedded Image )/Embedded Image .24 When technical issues precluded automated determination of VD/VT values using the NM3 monitor, a small percentage were calculated manually using the same equation and a value for Embedded Image that was pulled directly from the monitor at the coinciding time. Final VD/VT refers to the last VD/VT obtained before extubation; initial VD/VT is the first VD/VT obtained after intubation; mean VD/VT is the average of all VD/VT values during a subject’s course of invasive mechanical ventilation; and peak VD/VT is the maximum VD/VT obtained during a subject’s ventilator course.

Data Analysis

We used count and percentage or median and interquartile range (IQR) to describe categorical and continuous study variables, respectively. We compared the distribution of study variables among subjects who met or did not meet the primary and secondary end points using the Fisher exact or chi-square tests of association. We performed multivariable logistic regression analysis to evaluate the association between final VD/VT prior to extubation and extubation failure, controlling for duration of intubation, presence of cyanotic congenital heart disease, and postnatal age. We used Stata 14.1 (StataCorp, College Station, Texas) to conduct all statistical analyses; P < .05 was considered statistically significant.

Results

We enrolled 318 children in the study. After excluding 109 subjects based on our aforementioned criteria and 20 for whom we had incomplete data, we analyzed 189 subjects (Fig. 1). The following indications for invasive mechanical ventilation were present: cardiovascular disease, 108 (57%) subjects; operative/procedural, 102 (54%) subjects; hemodynamic instability, 52 (28%) subjects; pulmonary disease, 51 (27%) subjects; neurologic impairment, 32 (17%) subjects; and upper-airway obstruction, 4 (2%) subjects. The pre-extubation characteristics are summarized in Table 1. The median (IQR) age was 0.42 y (0.08–3.0). One hundred seven (56%) children were males. Eighty-one (43%) subjects were extubated in the pediatric multidisciplinary ICU (as opposed to the pediatric cardiac ICU), and 44 (23%) subjects had cyanotic congenital heart disease. Six (3%) subjects were extubated inadvertently. The median (IQR) duration of invasive ventilation prior to attempted extubation was 80 h (31–173). Average ventilator support at the time the final pre-extubation VD/VT was obtained was inspiratory pressure 12 ± 2 cm H2O, PEEP 5 ± 1 cm H2O, pressure support 10 ± 2 cm H2O, set frequency 18 ± 5 breaths/min, and Embedded Image 0.29 ± 0.09. The mode of mechanical ventilation when the final VD/VT was obtained was pressure support ventilation (97 subjects, 51.3%) or pressure control intermittent mandatory ventilation (86 subjects, 45.5%) for the majority of subjects, while a significantly smaller number were supported with pressure-regulated volume control ventilation (3 subjects, 1.6%) or continuous mandatory ventilation (1 subject, 0.5%) (data not available for 2 subjects).

Fig. 1.
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Fig. 1.

Flow chart of subject enrollment. ABG = arterial blood gas analysis.

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Table 1.

Baseline Subject Characteristics at Time of Extubation

Twenty-three subjects (12%) were re-intubated for the following reasons: 11 (48%) for cardiovascular disease, 8 (35%) for hemodynamic instability, 6 (26%) for operative/procedural, 5 (22%) for pulmonary disease, and 3 (13%) each for neurologic impairment and upper-airway obstruction. Those who were successfully extubated had similar final pre-extubation VD/VT to those who failed extubation, with a median (IQR) of 0.28 (0.20–0.37) vs 0.29 (0.21–0.33), respectively (P = .87) (Figure 2). Similarly, there were no significant differences between mean VD/VT (0.29 [IQR 0.22–0.37] vs 0.31 [IQR 0.24–0.37], P = .49) and peak VD/VT (0.37 [IQR 0.27–0.45] vs 0.42 [IQR 0.33–0.45], P = .15) during the course of invasive ventilation. Those who failed extubation had slightly higher initial VD/VT than those who successfully extubated, although this association did not meet statistical significance (0.30 [IQR 0.21–0.39] vs 0.39 [IQR 0.23–0.43], P = .067). Of the subjects who had upper-airway obstruction at the time of initial intubation, only 1 required an increase in respiratory support after extubation and was re-intubated. When we limited our analysis to compare only the 5 subjects who were re-intubated due to a pulmonary etiology versus those who were not (eg, excluding those with postextubation stridor), none of these parameters (eg, final VD/VT, mean VD/VT, peak VD/VT, initial VD/VT) reached statistical significance (Fig. 2).

Fig. 2.
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Fig. 2.

Differences in the dead space to tidal volume (VD/VT) between those who were extubated successfully and those who failed extubation. Black and white boxes represent all subjects, while gray and red boxes denote extubation outcome due to a pulmonary cause.

Table 2 summarizes the planned respiratory support upon extubation for the study subjects. Of the 188 subjects initially supported with noninvasive support upon extubation, 114 (61%) were extubated to high support. One subject who had been inadvertently extubated was immediately re-intubated and, therefore, did not have any planned postextubation support documented. As shown in Figure 3, those who were extubated to high support had higher final VD/VT than those who were extubated to low support (0.32 [IQR 0.23–0.39 vs 0.25 [IQR 0.16–0.30], P < .001), mean VD/VT (0.33 [IQR 0.25–0.40] vs 0.26 [IQR 0.20–0.32], P < .001), peak VD/VT (0.41 [IQR 0.32–0.51] vs 0.31 [IQR 0.22–0.39], P < .001), and initial VD/VT (0.34 [IQR 0.22–0.43] vs 0.28 [IQR 0.20–0.37], P = .005).

Fig. 3.
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Fig. 3.

Differences in the ratio of dead space to tidal volume (VD/VT) between those requiring low support and high support on extubation. Low support refers to room air or nasal cannula; high support refers to high-flow nasal cannula, CPAP, or bi-level positive airway pressure.

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Table 2.

Planned Respiratory Support Upon Extubation

Forty-four (23%) subjects required an escalation of support after extubation. There were no significant associations between requiring an escalation in support and final VD/VT (0.31 [IQR 0.22–0.38] vs 0.28 [IQR 0.20–0.36], P = .44), mean VD/VT (0.31 [IQR 0.22–0.39] vs 0.29 [IQR 0.23–0.36], P = .38), peak VD/VT (0.40 [IQR 0.31–0.45] vs 0.36 [IQR 0.27–0.45], P = .19), or initial VD/VT (0.35 [IQR 0.20–0.42] vs 0.29 [IQR 0.21–0.39], P = .36). These relationships are displayed in Figure 4.

Fig. 4.
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Fig. 4.

Differences in the ratio of dead space to tidal volume (VD/VT) between those who were extubated without escalation of support and those who required an escalation in support after extubation. Escalation refers to re-intubation, transition from low support (ie, room air or nasal cannula) to high support (ie, high-flow nasal cannula, CPAP, or bi-level positive airway pressure), or transition from high-flow nasal cannula to noninvasive ventilation.

Multivariate Analysis

In multivariate analysis, the adjusted odds ratio for increased final VD/VT and extubation failure was 0.11 (95% CI < 0.01–7.34, P = .30) when controlling for intubation duration, presence of cyanotic congenital heart disease, and age. For our secondary analyses, the adjusted odds ratio for an increase in VD/VT of ≥ 0.1 and high support upon extubation was 1.63 (95% CI 1.18–2.24, P = .003); and the adjusted odds ratio for an increase in final VD/VT of 0.1 and escalation in support after extubation was 1.01 (95% CI 0.74–1.38, P = .93), controlling for these same factors.

Discussion

In this prospective, observational, cohort study, we performed the largest analysis to date of the association between VD/VT and extubation success. In adjusted analysis, the final pre-extubation VD/VT was not associated with an increased risk of re-intubation when controlling for age, presence of cyanotic congenital heart disease, and duration of intubation. We did, however, find a significant association between final VD/VT and initial noninvasive respiratory support selected by the clinical team at the time of extubation.

Because VD/VT is a quantitative measure of physiologic dead space, its association with extubation failure would only pertain to those at risk of failing extubation from a pulmonary etiology (ie, those with increased alveolar dead space). We would not expect VD/VT to be associated with failure from other causes, such as upper-airway obstruction, which is the most common cause of extubation failure in children.1,4,5 However, when we limited our analysis to examine the 5 subjects who failed extubation due to a primarily pulmonary cause, the findings were unchanged from the analyses that included all causes for extubation failure.

Prior studies on this topic have yielded conflicting results. In a 2000 study of 45 subjects, Hubble et al19 reported a positive association between VD/VT > 0.65 and risk for extubation failure, whereas a VD/VT ≤ 0.50 was predictive of extubation success. Riou et al20 noted a similar association in a 2012 study of 42 children, albeit with a different VD/VT threshold. They reported that subjects with VD/VT ≤ 0.55 were significantly more likely to extubate without noninvasive support, which is consistent with our finding that those with higher VD/VT received noninvasive support upon extubation. In a recent retrospective study of children following surgical repair of congenital heart disease, Devor et al22 reported that VD/VT > 0.5 was associated with extubation failure in 61 children with 2-ventricle physiology but was not predictive for children with single-ventricle physiology. Additionally, Bousso et al21 reported that VD/VT > 0.65 was not predictive of re-intubation or of a need for noninvasive support following extubation in a study of 86 children.

Based on the studies by Hubble et al19 and Riou et al,20 the VD/VT threshold that appears to be associated with a higher risk of extubation failure is 0.50–0.55. In this context, it is important to highlight that the 95th percentile for pre-extubation VD/VT in our study was 0.53, indicating that a large majority of subjects we extubated fell below the increased risk threshold. This limitation of our study was likely driven by an institutional bias, as one of the earlier studies showing an association between VD/VT and extubation failure was performed at our center.19 Furthermore, the use of ERTs at our institution may have also limited attempts to extubate subjects with significant pulmonary pathology and higher VD/VT, which is supported by the relatively low average ventilator settings in our subjects when the final VD/VT values were obtained.

Although ours is still a relatively small study, one of its strengths is the number of subjects in comparison to the existing literature. We included a total of 189 subjects, which is more than twice as large as any prior study to evaluate VD/VT and extubation failure in pediatrics. Our study had fewer exclusion criteria than previous studies, but this was deliberate because one of our goals was to assess the utility of VD/VT as a global screening tool for extubation readiness regardless of indication for intubation, given that alveolar dead space can occur in patients intubated for nonpulmonary indications.

We intentionally included subjects with underlying chronic lung disease, given that alveolar dead space may affect successful extubation in these patients. However, the inclusion of these subjects may have confounded our results because it is possible that a subject’s underlying lung disease (and baseline respiratory support) affected the clinical team’s decision on timing of extubation as well as support after extubation. We also included subjects with cyanotic congenital heart disease in whom VD/VT may be elevated by variable amounts of intracardiac shunting because blood passing directly from venous to arterial circulations does so without a chance for CO2 elimination in the lungs.18 Although VD/VT does not differentiate between pulmonary dead space and intracardiac shunting, we opted to include both 2-ventricle and single-ventricle subjects with congenital heart disease given that an increased amount of dead space (even if impacted by intracardiac shunting) might impact the readiness for these children to successfully extubate.

An additional possible limitation is our decision to include subjects who had multiple episodes of invasive mechanical ventilation to capture the potential changes in physiology (and dead space) that can occur with each separate course of intubation. We also included inadvertent extubations because we strove to evaluate whether those with lower VD/VT would be more likely to tolerate extubation than those with high VD/VT in the event of accidental endotracheal tube dislodgement (although these subjects may have other risks for failure, such as persisting effects of sedation).

Although we did not see an association between VD/VT and extubation success, we did find that increased VD/VT was associated with providers’ selection of a higher level of postextubation respiratory support. There have been significant advancements in recent years that have improved the ability to manage patients noninvasively, as several relatively recent studies (of both adult25-27 and pediatric28 subjects) have shown benefit of early extubation to noninvasive support. Perhaps for this reason it is not entirely surprising that more than half of all subjects were extubated to HFNC, although this highly prevalent use of HFNC is a limitation of our study. Although it is premature to conclude that noninvasive support can help successfully bridge those with high VD/VT through extubation, further studies should seek to evaluate extubation criteria in a contemporary era of advanced noninvasive support.

There were other limitations to this study that may affect the generalizability of the results. By using only arterial specimens for blood gas analysis, we optimized the accuracy of our VD/VT values but may have, in turn, sacrificed the generalizability of the results to those who require an arterial sample from an arterial puncture or to those with arterial catheters, which may select for a sicker cohort of invasively ventilated patients. In addition, the observational design of the study leaves it open to potential biases. The management of the subjects, including timing of extubation, planned support on extubation, and decision to escalate support or re-intubate following extubation, was at the discretion of the clinical team. Because the providers were not blinded to the VD/VT data, clinician knowledge of the subjects’ VD/VT may have affected the decision for postextubation support. Therefore, it remains unclear whether VD/VT can be used to guide determination of which patients require noninvasive support at extubation.

Our multivariable analysis controlled for age, the presence of cyanotic congenital heart disease, and the duration of intubation; however, it is possible there were other confounding variables we could not control. The multivariable analysis was limited by our relatively limited sample size.

We considered transition from HFNC to either CPAP or BPAP an escalation in support because transition from noninvasive ventilation to HFNC rarely occurs in our practice. The design of the study may have also had implications because 83 subjects were excluded due to the lack of an ABG within 12 h of extubation. Since most blood gases are obtained in our ICUs around 4:00 am, there may have been a selective exclusion of subjects extubated in the evening (ie, > 12 h later).

Finally, this study was performed at a single center, limiting the generalizability of the results. While our re-intubation rate (12%) is within the range of what has been reported,1-7 the ideal re-intubation rate in pediatrics is unknown and likely differs based on the needs of individual centers, units, and patient populations.

Conclusions

We found no significant relationship between VD/VT and extubation success, but we did observe that higher VD/VT was associated with higher planned respiratory support on extubation. An elevated VD/VT at the time of extubation may serve to alert clinicians of patients who are at increased risk of respiratory distress/failure following extubation.

Footnotes

  • Correspondence: Jonathan A Gehlbach MD, The Children’s Hospital of Illinois at OSF St. Francis Medical Center, 530 NE Glen Oak Ave, Peoria, IL 61637. E-mail: jgehlb2{at}uic.edu
  • Dr Gehlbach presented a version of this paper at the American Thoracic Society International Conference, held May 21, 2017, in Washington, DC.

  • Dr Cheifetz has disclosed relationships with Philips Respironics and Up-to-Date. Mr Miller has disclosed a relationship with Ventec Life Systems. Drs Gehlbach and Hornik have disclosed no conflicts of interest.

  • Supplementary material related to this paper is available at http://www.rcjournal.com.

  • Copyright © 2020 by Daedalus Enterprises

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Respiratory Care: 65 (11)
Respiratory Care
Vol. 65, Issue 11
1 Nov 2020
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Dead Space to Tidal Volume Ratio Is Associated With Higher Postextubation Support in Children
Jonathan A Gehlbach, Andrew G Miller, Christoph P Hornik, Ira M Cheifetz
Respiratory Care Nov 2020, 65 (11) 1721-1729; DOI: 10.4187/respcare.07351

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Dead Space to Tidal Volume Ratio Is Associated With Higher Postextubation Support in Children
Jonathan A Gehlbach, Andrew G Miller, Christoph P Hornik, Ira M Cheifetz
Respiratory Care Nov 2020, 65 (11) 1721-1729; DOI: 10.4187/respcare.07351
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  • dead space
  • respiratory failure
  • extubation readiness
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