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Research ArticleReview

Patient-Ventilator Asynchronies: Clinical Implications and Practical Solutions

Lucia Mirabella, Gilda Cinnella, Roberta Costa, Andrea Cortegiani, Livio Tullo, Michela Rauseo, Giorgio Conti and Cesare Gregoretti
Respiratory Care November 2020, 65 (11) 1751-1766; DOI: https://doi.org/10.4187/respcare.07284
Lucia Mirabella
Department of Medical and Surgical Science, University of Foggia, Foggia, Italy.
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  • For correspondence: [email protected]
Gilda Cinnella
Department of Medical and Surgical Science, University of Foggia, Foggia, Italy.
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Roberta Costa
Department of Anesthesia and Intensive Care, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
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Andrea Cortegiani
Department of Surgical, Oncological and Oral Science, Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Palermo, Italy. Dr Gregoretti is affiliated with Istituto Fondazione G Giglio, Cefalù, Italy.
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Livio Tullo
Department of Medical and Surgical Science, University of Foggia, Foggia, Italy.
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Michela Rauseo
Department of Medical and Surgical Science, University of Foggia, Foggia, Italy.
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Giorgio Conti
Department of Anesthesia and Intensive Care, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
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Cesare Gregoretti
Department of Surgical, Oncological and Oral Science, Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Palermo, Italy. Dr Gregoretti is affiliated with Istituto Fondazione G Giglio, Cefalù, Italy.
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    Fig. 1.

    Several factors may cause asynchrony, some related to patient characteristics (eg, respiratory mechanics, effort), others related to the ventilator (eg, setting, level of assistance, cycling criteria) and to the interface used (ie, invasive or noninvasive). NIV = noninvasive ventilation.

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    Fig. 2.

    Asynchronies are common in both obstructive and restrictive patients, although alterations of the underlying respiratory mechanics generate different types of asynchronies. FRC = functional residual capacity; Te = expiratory time constant.

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    Fig. 3.

    Representative waveforms of flow (red track), Paw (yellow track), and Pes (blue track) in a patient receiving ventilatory support. The blue arrow shows a delay of > 100 ms between the beginning of inspiratory muscle activity and the beginning of mechanical inflation (ie, trigger delay). Paw = airway pressure; Pes = esophageal pressure.

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    Fig. 4.

    Representative waveforms of flow (red track), Paw (yellow track), and Pes (blue track) in a patient receiving ventilatory support. Arrows indicate ineffective effort. The ventilator is enable to detect the patient’s effort as a deflection on Pes generating only a bump in Flow and Paw tracings. Paw = airway pressure; Pes = esophageal pressure.

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    Fig. 5.

    Representative waveforms of flow (red track), Paw (yellow track), and Pes (blue track) in a patient receiving ventilatory support showing 2 samples of auto-triggering (blue arrows). A: 3 mandatory breaths are delivered in the absence of the patient’s inspiratory effort, separated by a very short expiratory time. B: A single mandatory breath is delivered in the absence of the patient’s inspiratory effort. Paw = airway pressure; Pes = esophageal pressure.

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    Fig. 6.

    Representative waveforms of flow (red track), Paw (yellow track), and Pes (blue track) in a patient receiving ventilatory support. The figure shows a double-triggering in the pressure support ventilation mode depicted by the presence of 2 inspiratory cycles separated by a very short expiratory time. Paw = airway pressure; Pes = esophageal pressure.

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    Fig. 7.

    Clinical implication of poor patient-ventilator interactions. VIDD = ventilator-induced diaphragmatic dysfunction.

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Respiratory Care: 65 (11)
Respiratory Care
Vol. 65, Issue 11
1 Nov 2020
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Patient-Ventilator Asynchronies: Clinical Implications and Practical Solutions
Lucia Mirabella, Gilda Cinnella, Roberta Costa, Andrea Cortegiani, Livio Tullo, Michela Rauseo, Giorgio Conti, Cesare Gregoretti
Respiratory Care Nov 2020, 65 (11) 1751-1766; DOI: 10.4187/respcare.07284

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Patient-Ventilator Asynchronies: Clinical Implications and Practical Solutions
Lucia Mirabella, Gilda Cinnella, Roberta Costa, Andrea Cortegiani, Livio Tullo, Michela Rauseo, Giorgio Conti, Cesare Gregoretti
Respiratory Care Nov 2020, 65 (11) 1751-1766; DOI: 10.4187/respcare.07284
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  • Article
    • Abstract
    • Introduction
    • Respiratory Physiology and Mechanical Ventilation
    • Asynchronies
    • Types of Asynchronies
    • Clinical Implications
    • How to Monitor Asynchronies
    • Strategies to Improve Patient-Ventilator Interaction
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Keywords

  • asynchrony
  • diaphragm
  • dyspnea
  • intensive care units
  • Mechanical ventilation
  • work of breathing

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