Skip to main content
 

Main menu

  • Home
  • Content
    • Current Issue
    • Editor's Commentary
    • Archives
    • Most-Read Papers of 2022
  • Authors
    • Author Guidelines
    • Submit a Manuscript
  • Reviewers
    • Reviewer Information
    • Create Reviewer Account
    • Reviewer Guidelines: Original Research
    • Reviewer Guidelines: Reviews
    • Appreciation of Reviewers
  • CRCE
    • Through the Journal
    • JournalCasts
    • AARC University
    • PowerPoint Template
  • Open Forum
    • 2023 Call for Abstracts
    • 2022 Abstracts
    • Previous Open Forums
  • Podcast
    • English
    • Español
    • Portugûes
    • 国语
  • Videos
    • Video Abstracts
    • Author Interviews
    • Highlighted Articles
    • The Journal

User menu

  • Subscribe
  • My alerts
  • Log in

Search

  • Advanced search
American Association for Respiratory Care
  • Subscribe
  • My alerts
  • Log in
American Association for Respiratory Care

Advanced Search

  • Home
  • Content
    • Current Issue
    • Editor's Commentary
    • Archives
    • Most-Read Papers of 2022
  • Authors
    • Author Guidelines
    • Submit a Manuscript
  • Reviewers
    • Reviewer Information
    • Create Reviewer Account
    • Reviewer Guidelines: Original Research
    • Reviewer Guidelines: Reviews
    • Appreciation of Reviewers
  • CRCE
    • Through the Journal
    • JournalCasts
    • AARC University
    • PowerPoint Template
  • Open Forum
    • 2023 Call for Abstracts
    • 2022 Abstracts
    • Previous Open Forums
  • Podcast
    • English
    • Español
    • Portugûes
    • 国语
  • Videos
    • Video Abstracts
    • Author Interviews
    • Highlighted Articles
    • The Journal
  • Twitter
  • Facebook
  • YouTube
Research ArticleOriginal Research

Risks of N95 Face Mask Use in Subjects With COPD

Sun Young Kyung, Yujin Kim, Hyunjoong Hwang, Jeong-Woong Park and Sung Hwan Jeong
Respiratory Care May 2020, 65 (5) 658-664; DOI: https://doi.org/10.4187/respcare.06713
Sun Young Kyung
Division of Pulmonology, Allergy and Critical Care, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yujin Kim
Division of Pulmonology, Allergy and Critical Care, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hyunjoong Hwang
Division of Pulmonology, Allergy and Critical Care, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jeong-Woong Park
Division of Pulmonology, Allergy and Critical Care, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sung Hwan Jeong
Division of Pulmonology, Allergy and Critical Care, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

Abstract

BACKGROUND: The N95 filtering facepiece respirator (FFR) is the most popular individual protective device to reduce exposure to particulate matter. However, concerns have been raised with regard to its use because it can increase respiratory resistance and dead space. Therefore, this study assessed the safety of N95 use in patients with COPD and air-flow limitation.

METHODS: This prospective study was performed at a tertiary hospital and enrolled 97 subjects with COPD. The subjects were monitored for symptoms and physiologic variables during a 10-min rest period and 6-min walking test while wearing an N95.

RESULTS: Of the 97 subjects, 7 with COPD did not wear the N95 for the entire test duration. This mask-failure group showed higher British modified Medical Research Council dyspnea scale scores and lower FEV1 percent of predicted values than did the successful mask use group. A modified Medical Research Council dyspnea scale score ≥ 3 (odds ratio 167, 95% CI 8.4 to >999.9; P = .008) or a FEV1 < 30% predicted (odds ratio 163, 95% CI 7.4 to >999.9; P = .001) was associated with a risk of failure to wear the N95. Breathing frequency, blood oxygen saturation, and exhaled carbon dioxide levels also showed significant differences before and after N95 use.

CONCLUSIONS: This study demonstrated that subjects with COPD who had modified Medical Research Council dyspnea scale scores ≥ 3 or FEV1 < 30% predicted wear N95s only with care.

  • Air pollution
  • COPD
  • particulate matter
  • respirators
  • respiratory protective devices
  • safety

Introduction

Particulate matter (PM) consists of a complex mixture of solid and liquid organic and inorganic particles suspended in the air.1 The most harmful particles are those with diameters ≤ 2.5 μm, which can penetrate and lodge deep inside the lungs.1,2 Exposure to air pollutants, including PM, is associated with negative health impacts, and PM is considered one of the most important air pollutants associated with adverse health problems worldwide.2,3 For example, many epidemiological studies have shown that PM has noxious effects in respiratory, cardiovascular, cerebrovascular, metabolic, and neuropsychiatric disorders as well as during pregnancy.4–7 PM exposure is also associated with increased exacerbation in patients with COPD, asthma, and several other respiratory diseases, which thus results in increased hospitalization and mortality.4,7–11 In addition, PM exposure increases the incidence of lung cancer and pneumonia.12,13

The best solution for reducing the health hazards associated with PM exposure is to remove the sources of PM via environmental interventions; however, this is very expensive and takes time. Therefore, individual interventions to protect against the adverse health effects of PM are required. The most popular practical solution to reduce individual exposure is the use of an N95 filtering facepiece respirator (N95 FFR), which is a respiratory protective device designed to achieve a very close facial fit and efficient filtration of airborne particles, blocking at least 95% of small particles (0.3 μm).14 N95s are most commonly used by health-care and industrial workers to minimize exposure to microorganisms or airborne dust.15–17 They are also frequently used in areas with high concentrations of air pollutants to protect against PM.15,18,19 The use of face masks to decrease personal PM exposure has been shown to reduce systolic blood pressure in healthy volunteers during a 2-h walk.15 Furthermore, N95 use during walking in areas with high atmospheric PM concentrations is associated with improvements in objective measures of myocardial ischemia, exercise-related increases in blood pressure, and heart rate variability in patients with coronary heart disease.20

However, the adverse physiologic impacts of N95 are a concern because N95 use can cause increased inspiratory and expiratory flow resistance and dead space.14 The increased flow resistance can cause an increase in tidal volume, a decrease in breathing frequency, and a decrease in minute ventilation, with a concomitant decrease in alveolar ventilation.14 In healthy subjects, wearing a gas mask increases breathing effort by ∼1.5-fold.21 In healthy health-care workers, N95 use did not cause any important physiologic burden during 1 h of use.22 However, continuous use of the N95 that exceeded 4 h was associated with the development of headaches.23 According to respiratory protection guidelines for the workplace, N95-induced increases in respiratory flow resistance, dead space, and physiologic load are small and generally well tolerated in healthy individuals and persons with impaired lung function.14 Nevertheless, when the elderly or patients with respiratory disease, heart disease, or stroke wear an N95 to reduce PM exposure, they should consult their physician about the safety of N95 use.24 The balance between the risks and benefits of N95 use in these patients, particularly patients with chronic pulmonary function impairment, is unclear. Therefore, we evaluated the safety and risk of N95 use in subjects with COPD, which is associated with chronic air-flow limitation and is substantially affected by PM exposure.

QUICK LOOK

Current knowledge

Previous studies indicate that the use of the N95 face mask in patients with mild respiratory disease (FEV1 ≥ 50%) did not induce significant adverse effects. However, the use of the N95 face mask could induce an increase in flow resistance and dead space.

What this paper contributes to our knowledge

In this prospective study, we evaluated the physiologic impacts of N95 face mask use in subjects with COPD and severe air-flow obstruction. Patients with COPD and with modified Medical Research Council dyspnea scale scores ≥ 3 or FEV1 < 30% predicted should be careful when using N95 face masks because these may increase the risk of dyspnea and breathing discomfort.

Methods

Study Design and Subjects

A prospective panel study was performed between March and May 2015 at a tertiary hospital of Incheon, South Korea. In total, 97 patients were recruited from the Gachon University Gil Medical Center (Incheon, South Korea). All the subjects were diagnosed with COPD and were treated in the pulmonary division, with regular visits to the out-patient department. The inclusion criteria were age 19–80 y old, smoking history > 10 pack-years, and adequate physical activity to allow for hospital visitation via unassisted walking. The exclusion criteria were severe respiratory failure with long-term oxygen therapy; history of hospital admission within the previous 3 months due to COPD exacerbation; a history of invasive mechanical ventilation or noninvasive ventilation; severe renal or hepatic failure; history of heart failure; history of acute cardiovascular or cerebrovascular event within the previous 2 months; advanced stage of malignancy, with an expected survival within 6 months; or other severe pulmonary diseases (eg, tuberculosis-destroyed lung and severe bronchiectasis). Baseline data, including smoking history, the British modified Medical Research Council dyspnea scale (mMRC) questionnaire results, COPD Assessment Test (CAT) score, and spirometry and laboratory measurements were recorded in the case report forms.

All the subjects provided written informed consent, and the study was reviewed and approved by the institutional review board of Gachon University Gil Medical Center (GBIRB2015-300). The subjects were monitored for symptoms and safety during a 10-min rest period and 6-min walk test (6MWT) while wearing an N95 (3M 9210, 3M, St. Paul, Minnesota). We purchased the 3M 9210 face mask for this study; however, this device is no longer being manufactured (since 2014). Electrocardiogram and SpO2 monitoring were continuous during the study. Systolic blood pressure, diastolic blood pressure, heart rate, breathing frequency, Embedded Image, and exhaled carbon dioxide (Embedded Image) were measured at baseline and during the 6MWT without a mask, 10 min rest with a mask, and 6MWT with a mask. If the subjects felt too uncomfortable to wear the N95 or their physiologic variables became unstable, they removed the mask immediately; these subjects were included in the mask failure group. Investigators (SYK, YJK, HJH) attended to these subjects and monitored them carefully until recovery.

Baseline Data Collection and Classification of COPD

The severity of COPD was evaluated by using the mMRC score, CAT score, and postbronchodilator FEV1 percent of predicted according to the Global Initiative for Chronic Obstructive Lung Disease guidelines.25 The mMRC dyspnea scale is a simple measure of breathlessness in COPD: grade 0, only experiences breathlessness on strenuous exercise; grade 1, experiences shortness of breath when hurrying on level ground or walking up a slight hill; grade 2, walks on level ground slower than people of the same age due to breathlessness or stops to catch breath when walking at a comfortable pace on level ground; grade 3, stops to catch breath after walking ∼100 m or after a few minutes on level ground; and grade 4, too breathless to leave the house or breathless when dressing or undressing. The CAT is an 8-item unidimensional measure of health status impairment in patients with COPD. The score ranges from 0 to 40 and is closely correlated with the quality of life. The severity of air-flow obstruction in COPD was categorized by using postbronchodilator FEV1 percent of predicted: FEV1 ≥ 80% predicted; FEV1, 50–79% predicted; FEV1, 30–49% predicted; and FEV1 < 30% predicted.

Physiologic Variables and Symptom Questionnaire

Heart rate, breathing frequency, and SpO2 were continuously monitored by using electrocardiogram monitoring and pulse oximetry during the study. Systolic blood pressure, diastolic blood pressure, and Embedded Image were measured at baseline and during the 6MWT without a mask, 10-min rest with a mask, and 6MWT with a mask. Embedded Image was measured by using capnography and was expressed as the mean (mm Hg) of 3 respirations. Symptoms associated with N95 use were evaluated by using a symptom questionnaire that included the presence of dyspnea, headache, dizziness, anxiety, facial pressure, and skin irritation.

Statistical Analyses

We used IBM SPSS Statistics for Windows/Macintosh, Version 23.0 (IBM, Armonk, New York) and SAS version 9.4 (SAS Institute, Cary, North Carolina) for statistical analyses. Categorical variables were compared by using the Fisher exact test, and continuous variables were compared by using the Mann–Whitney test, between the successful mask use group and mask failure group. To identify differences in the physiologic variables, repeated-measures analysis of variance was performed for blood pressure, heart rate, breathing frequency, SpO2, and Embedded Image by using the values from the baseline data without a mask as the covariant. The impacts of potential risk factors of the failure to wear a mask were analyzed by using univariate logistic regression analyses. Significant variables in the univariate analyses were included in the multivariate logistic regression analyses by using the Firth method to identify independent risk factors of N95 safety. The Firth method was used because one cell had a value of zero. Independent influences of risk factors of N95 safety were expressed as the odds ratio with 95% CI. Significance was considered as P < .05.

Results

Subject Characteristics

The mean ± SD age of the subjects was 68 ± 6.5 y and 94% were male subjects. The mean ± SD mMRC score was 1.5 ± 0.9 and the mean ± SD CAT score was 15.1 ± 8.2. The mean FEV1 was 57.1% predicted and the most common air-flow obstruction category was moderate (FEV1, 50–79% predicted; n = 58). Seven of the 97 subjects with COPD (7.2%) failed to wear the N95 during the test (Table 1). The mask failure group (n = 7) showed significantly higher mMRC scores and CAT scores as well as lower FEV1/FVC, FEV1, FVC, and SpO2 values than did the successful mask use group (n = 90). The subjects who failed to wear the mask had an mMRC score ≥ 3 and FEV1 < 50% predicted. The most common mask-associated symptom was dyspnea (n = 8); however, the subjects who failed to wear the mask had dizziness or headache as well as dyspnea.

View this table:
  • View inline
  • View popup
  • Download powerpoint
Table 1.

Characteristics of the Subjects and Differences According to N95 Safety Outcome

Risk Factors for the Development of N95–Associated Complications

According to the multivariate logistic regression analyses, the independent risk factors for the failure to wear the mask included a high mMRC score, with an odds ratio of 12.58, 95% CI 1.49–105.95 (P = .02) (Table 2). In particular, an mMRC score of 3 was associated with a 167-fold increased risk of failure to wear the mask (95% CI 8.43 to >999.99; P < .001) (Table 3). In addition, FEV1 < 30% predicted was associated with a 162.5-fold increased risk of failure to wear the mask (95% CI 7.36 to >999.99; P = .001).

View this table:
  • View inline
  • View popup
  • Download powerpoint
Table 2.

Risk Factors for the Development of N95 Complications

View this table:
  • View inline
  • View popup
  • Download powerpoint
Table 3.

Risk of N95 Failure According to Binary Values of mMRC and FEV1%

Characteristics of the Mask Failure Group

Only one subject failed to wear the mask after 8 min during the rest period and showed increased Embedded Image and mask-associated symptoms, such as headache, dizziness, and facial pressure (Table 4). Most of the subjects (n = 6) in the mask failure group removed the mask during the 6MWT due to low SpO2 or CO2 retention. All the subjects exhibited decreased SpO2, increased Embedded Image, and dyspnea.

View this table:
  • View inline
  • View popup
  • Download powerpoint
Table 4.

Characteristics and Mask-Associated Symptoms in Subjects in the Mask Failure Group

Physiologic Variables before and after Mask Use in the Successful Mask Use Group

In the mask-safe group, the breathing frequency, SpO2, and Embedded Image significantly differed before and after N95 use for 10 min in a resting state (Table 5). The heart rate, breathing frequency, and Embedded Image were significantly higher after the 6MWT with a mask than after the 6MWT without a mask. The SpO2 levels were significantly lower after the 6MWT with a mask than after the 6MWT without a mask.

View this table:
  • View inline
  • View popup
  • Download powerpoint
Table 5.

Physiologic Variables after Use of N95 in Subjects Who Successfully Used a Mask

Discussion

To our knowledge, this was the first study on the safety of N95 use in subjects with COPD and severely limited air flow. Patients with COPD are sensitive to PM, which can induce exacerbation of COPD, and experience respiratory failure, which can increase the risk of N95 use. The results of this study indicated that the subjects with COPD and with mMRC scores ≥ 3 or FEV1 < 30% predicted should be careful to use N95s due to the increased risk for inducing hypoxic or hypercapnic respiratory failure.

The mean FEV1 of the subjects enrolled in this study was 57.1% predicted, and 31 of the 97 subjects had an FEV1 < 50% predicted. All the subjects were able to walk during regular out-patient clinic visits and showed stable baseline respiratory variables. The subjects were monitored continuously via electrocardiograms as well as for breathing frequency, SpO2, and subjective response by a respiratory physician (SYK, YJK, HJH) throughout the experiment. A number of studies examined the physiologic effects of face masks in subjects with mild respiratory disease (eg, asthma, COPD, and chronic rhinitis) while performing simulated work tasks.26–29 For example, Harber et al26 reported that subjects with mild COPD or asthma experienced adverse effects on ventilation while wearing half-mask respirators, which differ from N95s. In their study, the subjects with severe COPD and with an FEV1 < 50% predicted were excluded.27 They concluded that the respirator significantly affected several physiologic variables and subjective responses, and that the type of lung disease (eg, mild asthma or COPD) did not significantly affect the results.27 In contrast, we enrolled and performed close monitoring of subjects with severe COPD, and these subjects showed significant adverse effects in terms of respiratory variables and subjective symptoms while resting or walking for 6 min and wearing an N95.

The adverse effects of N95 use in healthy people were originally studied in workers while the workers were wearing required respirators and showed elevated CO2 levels and decreased O2 levels during a qualitative respirator fit test.30 In addition, the physiologic impact of the N95 has been studied in health-care workers.22,23 Although the mask did not cause any adverse physiologic effects during 1 h of use, continuous use of the N95 for >4 h was associated with headaches and two subjects showed peak transcutaneous CO2 levels > 50 mm Hg.23 The effects of N95 use have also been assessed in pregnant women.31–33 No differences were observed between pregnant and nonpregnant women in terms of physiologic variables (eg, heart rate, breathing frequency, O2 saturation, or transcutaneous CO2 level) after wearing an N95 for 1 h during sedentary activity or exercise.31 However, exercising at 3 Metabolic Equivalent of Task while breathing through an N95 reduced the tidal volume, minute ventilation, and exhaled O2 concentration but increased exhaled CO2 concentration in pregnant women.32 These results suggest that breathing through an N95 impedes gas exchange in pregnant women, and these factors should be considered when recommending N95 use.

According to the respiratory protection guideline of the American Thoracic Society,14 FFRs generally induce minimum adverse physiologic effects and are tolerated by both healthy individuals and persons with impaired lung function. However, the American Thoracic Society agrees that FFR use can increase breathing resistance, dead space, and physiologic load. In particular, Lee and Wang34 reported that N95 (model 8210; 3M) use yielded mean increments of 126% and 122% in inspiratory and expiratory flow resistance, respectively, measured by using rhinomanometry. Moreover, they reported that N95 use induced a mean 37% reduction in air-exchange volume.34 According to the guideline for physicians of the Hong Kong Medical Association, the elderly, people with illness (eg, chronic lung disease, heart disease, or stroke), and pregnant women should consult their physician to determine whether they can use N95s because they may already have reduced lung volumes.24

In a study on the efficacy of N95s in subjects with coronary heart disease, the subjects walked for 2 h while wearing an N95.20 All 96 subjects enrolled in that study tolerated the mask intervention well. Moreover, the mean ambulatory arterial blood pressure and heart rate were more stable in the subjects who used masks than in those who did not use a mask. Although patients with uncontrolled heart failure were excluded from that study, the results indicate that N95 use for <2 h is safe for people with coronary heart disease in a stable state.20 Unlike that study, we found that subjects with COPD enrolled in this study showed significant differences in physiologic variables, depending on whether they used a mask. The subjects showed worsening of respiratory variables when they wore an N95, including increased breathing frequency, Embedded Image, and decreased SpO2. When considering the increase in respiratory resistance with N95 use, patients with COPD and low baseline pulmonary function may be considered to have a greater physiologic impact with mask use.

A major limitation of this study was that it was performed at a single center with a relatively small mask failure group. Nevertheless, the results are sufficient for informing guidelines on safe N95 use in patients with COPD. In the future, a larger population should be recruited from multiple institutes. Another limitation is that we used the 6MWT to evaluate the safety of N95 use during exercise. The 6MWT is simple and is often used to evaluate exercise tolerance. However, the safety of N95 use during 6 min of walking may not adequately reflect safety under real outdoor conditions; outdoor activities may last for varying durations of time and may involve varying levels of exertion. Most of the subjects in the mask failure group showed hypoxemia or hypercapnia and mask-associated symptoms during the 6MWT. Furthermore, other susceptible patients, such as those with asthma or severe heart failure, should be included in future studies of N95 use safety.

Conclusions

We generally recommend the use of N95s for patients with COPD for protection against PM exposure during outdoor activity under high PM conditions. However, patients with very severe COPD, mMRC scores ≥ 3, or FEV1 < 30% predicted should be careful when using N95s. Performance of the 6MWT while wearing the N95 may predict mask-associated risks in patients with severe COPD. Also, patients should be warned to remove the N95s immediately on the onset of dyspnea, headache, or dizziness.

Footnotes

  • Correspondence: Sung Hwan Jeong MD PhD, Division of Pulmonology, Allergy and Critical Care, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, 21565 Namdong-daero 774-21, Guwol-dong, Incheon, Republic of Korea. E-mail: jsw{at}gilhospital.com
  • This study was supported by a Korea Centers for Disease Control and Prevention grant [HD15A1482].

  • The authors have disclosed no conflicts of interest.

  • Copyright © 2020 by Daedalus Enterprises

References

  1. 1.↵
    Air quality guidelines global update 2005: particulate matter, ozone, nitrogen dioxide and sulfur dioxide. World Health Organization Regional Office for Europe; 2006. Available at: http://www.who.int/iris/handle/10665/107823. Accessed June 3, 2019.
  2. 2.↵
    Review of evidence on health aspects of air pollution: REVIHAAP Project. World Health Organization Regional Office for Europe; 2013. Available at: http://www.euro.who.int/en/health-topics/environment-and-health/air-quality/publications/2013/review-of-evidence-on-health-aspects-of-air-pollution-revihaap-project-final-technical-report. Accessed June 3, 2019.
  3. 3.↵
    Ambient air pollution: a global assessment of exposure and burden of disease. Geneva: World Health Organization; 2016. Available at: https://www.who.int/phe/publications/air-pollution-global-assessment/en/. Accessed June 3, 2019.
  4. 4.↵
    1. Dockery DW,
    2. Pope CA III.,
    3. Xu X,
    4. Spengler JD,
    5. Ware JH,
    6. Fay ME,
    7. et al
    . An association between air pollution and mortality in six U.S. cities. N Engl J Med 1993;329(24):1753–1759.
    OpenUrlCrossRefPubMed
  5. 5.
    1. Pope CA III.,
    2. Dockery DW
    . Health effects of fine particulate air pollution: lines that connect. J Air Waste Manag Assoc 2006;56(6):709–742.
    OpenUrlCrossRefPubMed
  6. 6.
    1. Thurston GD,
    2. Kipen H,
    3. Annesi-Maesano I,
    4. Balmes J,
    5. Brook RD,
    6. Cromar K,
    7. et al
    . A joint ERS/ATS policy statement: what constitutes an adverse health effect of air pollution? An analytical framework. Eur Respir J 2017;49(1). pii: 1600419.
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. Pope CA III.,
    2. Burnett RT,
    3. Thun MJ,
    4. Calle EE,
    5. Krewski D,
    6. Ito K,
    7. Thurston GD
    . Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA 2002;287(9):1132–1141.
    OpenUrlCrossRefPubMed
  8. 8.
    1. Schikowski T,
    2. Adam M,
    3. Marcon A,
    4. Cai Y,
    5. Vierkötter A,
    6. Carsin AE,
    7. et al
    . Association of ambient air pollution with the prevalence and incidence of COPD. Eur Respir J 2014;44(3):614–626.
    OpenUrlAbstract/FREE Full Text
  9. 9.
    1. Gan WQ,
    2. FitzGerald JM,
    3. Carlsten C,
    4. Sadatsafavi M,
    5. Brauer M
    . Associations of ambient air pollution with chronic obstructive pulmonary disease hospitalization and mortality. Am J Respir Crit Care Med 2013;187(7):721–727.
    OpenUrlCrossRefPubMed
  10. 10.
    1. Guarnieri M,
    2. Balmes JR
    . Outdoor air pollution and asthma. Lancet 2014;383(9928):1581–1592.
    OpenUrlCrossRefPubMed
  11. 11.↵
    1. Ko FW,
    2. Tam W,
    3. Wong TW,
    4. Chan DP,
    5. Tung AH,
    6. Lai CK,
    7. Hui DS
    . Temporal relationship between air pollutants and hospital admissions for chronic obstructive pulmonary disease in Hong Kong. Thorax 2007;62(9):780–785.
    OpenUrlAbstract/FREE Full Text
  12. 12.↵
    1. Raaschou-Nielsen O,
    2. Andersen ZJ,
    3. Beelen R,
    4. Samoli E,
    5. Stafoggia M,
    6. Weinmayr G,
    7. et al
    . Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE). Lancet Oncol 2013;14(9):813–822.
    OpenUrlCrossRefPubMed
  13. 13.↵
    1. MacIntyre EA,
    2. Gehring U,
    3. Mölter A,
    4. Fuertes E,
    5. Klümper C,
    6. Krämer U,
    7. et al
    . Air pollution and respiratory infections during early childhood: an analysis of 10 European birth cohorts within the ESCAPE Project. Environ Health Perspect 2014;122(1):107–113.
    OpenUrlPubMed
  14. 14.↵
    1. Harber P,
    2. Barnhart S,
    3. Boehlecke BA,
    4. Beckett WS,
    5. Gerrity T,
    6. Mcdiarmid MA,
    7. et al
    . Respiratory protection guidelines. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, March 1996. Am J Respir Crit Care Med 1996;154(4 Pt 1):1153–1165.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Langrish JP,
    2. Mills NL,
    3. Chan JK,
    4. Leseman DL,
    5. Aitken RJ,
    6. Fokkens PH,
    7. et al
    . Beneficial cardiovascular effects of reducing exposure to particulate air pollution with a simple facemask. Part Fibre Toxicol 2009;6:8.
    OpenUrlCrossRefPubMed
  16. 16.
    1. Rengasamy A,
    2. Zhuang Z,
    3. Berryann R
    . Respiratory protection against bioaerosols: literature review and research needs. Am J Infect Control 2004;32(6):345–354.
    OpenUrlCrossRefPubMed
  17. 17.↵
    1. Radonovich LJ Jr.,
    2. Simberkoff MS,
    3. Bessesen MT,
    4. Brown AC,
    5. Cummings DAT,
    6. Gaydos CA,
    7. et al
    . N95 respirators vs medical masks for preventing influenza among health care personnel: a randomized clinical trial. JAMA 2019;322(9):824–833.
    OpenUrlCrossRef
  18. 18.↵
    1. Cherrie JW,
    2. Apsley A,
    3. Cowie H,
    4. Steinle S,
    5. Mueller W,
    6. Lin C,
    7. et al
    . Effectiveness of face masks used to protect Beijing residents against particulate air pollution. Occup Environ Med 2018;75(6):446–452.
    OpenUrlAbstract/FREE Full Text
  19. 19.↵
    1. Laumbach R,
    2. Meng Q,
    3. Kipen H
    . What can individuals do to reduce personal health risks from air pollution? J Thorac Dis 2015;7(1):96–107.
    OpenUrlPubMed
  20. 20.↵
    1. Langrish JP,
    2. Li X,
    3. Wang S,
    4. Lee MM,
    5. Barnes GD,
    6. Miller MR,
    7. et al
    . Reducing personal exposure to particulate air pollution improves cardiovascular health in patients with coronary heart disease. Environ Health Perspect 2012;120(3):367–372.
    OpenUrlCrossRefPubMed
  21. 21.↵
    1. Bourassa S,
    2. Bouchard PA,
    3. Lellouche F
    . Impact of gas mask on work of breathing, breathing patterns, and gas exchange in healthy subjects. Respir Care 2018;63(11):1350–1359.
    OpenUrlAbstract/FREE Full Text
  22. 22.↵
    1. Roberge RJ,
    2. Coca A,
    3. Williams WJ,
    4. Powell JB,
    5. Palmiero AJ
    . Physiological impact of the N95 filtering facepiece respirator on healthcare workers. Respir Care 2010;55(5):569–577.
    OpenUrlAbstract/FREE Full Text
  23. 23.↵
    1. Lim EC,
    2. Seet RC,
    3. Lee KH,
    4. Wilder,
    5. Smith EP,
    6. Chuah BY,
    7. Ong BK
    . Headaches and the N95 face‐mask amongst healthcare providers. Acta Neurol Scand 2006;113(3):199–202.
    OpenUrlCrossRefPubMed
  24. 24.↵
    Guidance for physicians: on assessment of medical fitness to use respirators in conditions of high air quality health index. Hong Kong Medical Association, Labour Department, Department of Health, Environmental Protection Department; 2013. December. Available at: https://www.epd.gov.hk/epd/english/envir_standards/non_statutory/files/Guidance_for_Physicians_eng_2013.pdf. Accessed by June 3, 2019.
  25. 25.↵
    1. Vestbo J,
    2. Hurd SS,
    3. Agusti AG,
    4. Jones PW,
    5. Vogelmeier C,
    6. Anzueto A,
    7. et al
    . Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2013;187(4):347–365.
    OpenUrlCrossRefPubMed
  26. 26.↵
    1. Bansal S,
    2. Harber P,
    3. Yun D,
    4. Liu D,
    5. Liu Y,
    6. Wu S,
    7. et al
    . Respirator physiological effects under simulated work conditions. J Occup Environ Hyg 2009;6(4):221–227.
    OpenUrlCrossRefPubMed
  27. 27.↵
    1. Harber P,
    2. Santiago S,
    3. Bansal S,
    4. Liu Y,
    5. Yun D,
    6. Wu S
    . Respirator physiologic impact in persons with mild respiratory disease. J Occup Environ Med 2010;52(2):155–162.
    OpenUrlPubMed
  28. 28.
    1. Harber P,
    2. Santiago S,
    3. Wu S,
    4. Bansal S,
    5. Liu Y,
    6. Yun D
    . Subjective response to respirator type: effect of disease status and gender. J Occup Environ Med 2010;52(2):150–154.
    OpenUrlPubMed
  29. 29.↵
    1. Raven PB,
    2. Jackson AW,
    3. Page K,
    4. Moss RF,
    5. Bradley O,
    6. Skaggs B
    . The physiological responses of mild pulmonary impaired subjects while using a “demand” respirator during rest and work. Am Ind Hyg Assoc J 1981;42(4):247–257.
    OpenUrlPubMed
  30. 30.↵
    1. Laferty EA,
    2. McKay RT
    . Physiologic effects and measurement of carbon dioxide and oxygen levels during qualitative respirator fit testing. J Chem Health Saf 2006;13(5):22–28.
    OpenUrl
  31. 31.↵
    1. Roberge RJ,
    2. Kim JH,
    3. Powell JB
    . N95 respirator use during advanced pregnancy. Am J Infect Control 2014;42(10):1097–1100.
    OpenUrlPubMed
  32. 32.↵
    1. Tong PS,
    2. Kale AS,
    3. Ng K,
    4. Loke AP,
    5. Choolani MA,
    6. Lim CL,
    7. et al
    . Respiratory consequences of N95-type mask usage in pregnant healthcare workers—a controlled clinical study. Antimicrob Resist Infect Control 2015;4:48. eCollection 2015. Erratum in: Antimicrob Resist Infect Control. 2016;5:e26.
    OpenUrl
  33. 33.↵
    1. Roberge RJ
    . Physiological burden associated with the use of filtering facepiece respirators (N95 masks) during pregnancy. J Womens Health (Larchmt) 2009;18(6):819–826.
    OpenUrlPubMed
  34. 34.↵
    1. Lee HP,
    2. Wang de Y
    . Objective assessment of increase in breathing resistance of N95 respirators on human subjects. Ann Occup Hyg 2011;55(8):917–921.
    OpenUrlCrossRefPubMed
PreviousNext
Back to top

In this issue

Respiratory Care: 65 (5)
Respiratory Care
Vol. 65, Issue 5
1 May 2020
  • Table of Contents
  • Table of Contents (PDF)
  • Cover (PDF)
  • Index by author

 

Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on American Association for Respiratory Care.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Risks of N95 Face Mask Use in Subjects With COPD
(Your Name) has sent you a message from American Association for Respiratory Care
(Your Name) thought you would like to see the American Association for Respiratory Care web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Risks of N95 Face Mask Use in Subjects With COPD
Sun Young Kyung, Yujin Kim, Hyunjoong Hwang, Jeong-Woong Park, Sung Hwan Jeong
Respiratory Care May 2020, 65 (5) 658-664; DOI: 10.4187/respcare.06713

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Risks of N95 Face Mask Use in Subjects With COPD
Sun Young Kyung, Yujin Kim, Hyunjoong Hwang, Jeong-Woong Park, Sung Hwan Jeong
Respiratory Care May 2020, 65 (5) 658-664; DOI: 10.4187/respcare.06713
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

Related Articles

Cited By...

Keywords

  • Air pollution
  • COPD
  • particulate matter
  • respirators
  • respiratory protective devices
  • Safety

Info For

  • Subscribers
  • Institutions
  • Advertisers

About Us

  • About the Journal
  • Editorial Board

AARC

  • Membership
  • Meetings
  • Clinical Practice Guidelines

More

  • Contact Us
  • RSS
American Association for Respiratory Care

Print ISSN: 0020-1324        Online ISSN: 1943-3654

© Daedalus Enterprises, Inc.

Powered by HighWire