Review ArticleSystematic Review

Probiotics for the Prevention of Ventilator-Associated Pneumonia: A Meta-Analysis of Randomized Controlled Trials

Minmin Su, Ying Jia, Yan Li, Dianyou Zhou and Jinsheng Jia
Respiratory Care May 2020, 65 (5) 673-685; DOI: https://doi.org/10.4187/respcare.07097

References

  1. 1.↵
    1. Wolfensberger A,
    2. Meier MT,
    3. Clack L,
    4. Schreiber PW,
    5. Sax H
    . Preventing ventilator-associated pneumonia-a mixed-method study to find behavioral leverage for better protocol adherence. Infect Control Hosp Epidemiol 2018;39(10):1222–1229.
    OpenUrl
  2. 2.↵
    1. Nasiriani K,
    2. Torki F,
    3. Jarahzadeh MH,
    4. Rashidi Maybodi F
    . The effect of brushing with a soft toothbrush and distilled water on the incidence of ventilator-associated pneumonia in the intensive care unit. Tanaffos 2016;15(2):101–107.
    OpenUrl
  3. 3.↵
    1. Dudeck MA,
    2. Weiner LM,
    3. Allen-Bridson K,
    4. Malpiedi PJ,
    5. Peterson KD,
    6. Pollock DA,
    7. et al
    . National Healthcare Safety Network (NHSN) report, data summary for 2012, device-associated module. Am J Infect Control 2013;41(12):1148–1166.
    OpenUrlCrossRefPubMedWeb of Science
  4. 4.↵
    1. Zeng J,
    2. Wang CT,
    3. Zhang FS,
    4. Qi F,
    5. Wang SF,
    6. Ma S,
    7. et al
    . Effect of probiotics on the incidence of ventilator-associated pneumonia in critically ill patients: a randomized controlled multicenter trial. Intensive Care Med 2016;42(6):1018–1028.
    OpenUrl
  5. 5.↵
    1. Meidani M,
    2. Khorvash F,
    3. Abbasi S,
    4. Cheshmavar M,
    5. Tavakoli H
    . Oropharyngeal irrigation to prevent ventilator-associated-pneumonia: comparing potassium permanganate with chlorhexidine. Int J Prev Med 2018;9:93.
    OpenUrl
  6. 6.↵
    1. Sharma G,
    2. Im SH
    . Probiotics as a potential immunomodulating pharmabiotics in allergic diseases: current status and future prospects. Allergy Asthma Immunol Res 2018;10(6):575–590.
    OpenUrl
  7. 7.
    1. Boulangé CL,
    2. Neves AL,
    3. Chilloux J,
    4. Nicholson JK,
    5. Dumas ME
    . Impact of the gut microbiota on inflammation, obesity, and metabolic disease. Genome Med 2016;8(1):42.
    OpenUrlCrossRefPubMed
  8. 8.↵
    1. Meijnikman AS,
    2. Gerdes VE,
    3. Nieuwdorp M,
    4. Herrema H
    . evaluating causality of gut microbiota in obesity and diabetes in humans. Endocr Rev 2018;39(2):133–153.
    OpenUrl
  9. 9.↵
    1. Liu KX,
    2. Zhu YG,
    3. Zhang J,
    4. Tao LL,
    5. Lee JW,
    6. Wang XD,
    7. Qu JM
    . Probiotics' effects on the incidence of nosocomial pneumonia in critically ill patients: a systematic review and meta-analysis. Crit Care 2012;16(3):R109.
    OpenUrlCrossRefPubMed
  10. 10.↵
    1. Karacaer F,
    2. Hamed I,
    3. Özogul F,
    4. Glew RH,
    5. Özcengiz D
    . The function of probiotics on the treatment of ventilator-associated pneumonia (VAP): facts and gaps. J Med Microbiol 2017;66(9):1275–1285.
    OpenUrl
  11. 11.↵
    1. Boyer AF,
    2. Kollef MH
    . Probiotics for ventilator-associated pneumonia: the need for a large, multicenter, randomized controlled trial. Chest 2013;143(3):590–592.
    OpenUrl
  12. 12.↵
    1. Giamarellos-Bourboulis EJ,
    2. Bengmark S,
    3. Kanellakopoulou K,
    4. Kotzampassi K
    . Pro- and synbiotics to control inflammation and infection in patients with multiple injuries. J Trauma 2009;67(4):815–821.
    OpenUrlCrossRefPubMed
  13. 13.↵
    1. Kotzampassi K,
    2. Giamarellos-Bourboulis EJ,
    3. Voudouris A,
    4. Kazamias P,
    5. Eleftheriadis E
    . Benefits of a synbiotic formula (Synbiotic 2000Forte) in critically Ill trauma patients: early results of a randomized controlled trial. World J Surg 2006;30(10):1848–1855.
    OpenUrlCrossRefPubMedWeb of Science
  14. 14.↵
    1. Morrow LE,
    2. Kollef MH,
    3. Casale TB
    . Probiotic prophylaxis of ventilator-associated pneumonia: a blinded, randomized, controlled trial. Am J Respir Crit Care Med 2010;182(8):1058–1064.
    OpenUrlCrossRefPubMedWeb of Science
  15. 15.↵
    1. Shimizu K,
    2. Yamada T,
    3. Ogura H,
    4. Mohri T,
    5. Kiguchi T,
    6. Fujimi S,
    7. et al
    . Synbiotics modulate gut microbiota and reduce enteritis and ventilator-associated pneumonia in patients with sepsis: a randomized controlled trial. Crit Care 2018;22(1):239.
    OpenUrl
  16. 16.↵
    1. Spindler-Vesel A,
    2. Bengmark S,
    3. Vovk I,
    4. Cerovic O,
    5. Kompan L
    . Synbiotics, prebiotics, glutamine, or peptide in early enteral nutrition: a randomized study in trauma patients. JPEN J Parenter Enteral Nutr 2007;31(2):119–126.
    OpenUrlCrossRefPubMedWeb of Science
  17. 17.↵
    1. Klarin B,
    2. Adolfsson A,
    3. Torstensson A,
    4. Larsson A
    . Can probiotics be an alternative to chlorhexidine for oral care in the mechanically ventilated patient? A multicentre, prospective, randomised controlled open trial. Crit Care 2018;22(1):272.
    OpenUrl
  18. 18.↵
    1. Mahmoodpoor A,
    2. Hamishehkar H,
    3. Asghari R,
    4. Abri R,
    5. Shadvar K,
    6. Sanaie S
    . Effect of a probiotic preparation on ventilator-associated pneumonia in critically ill patients admitted to the intensive care unit: a prospective double-blind randomized controlled trial. Nutr Clin Pract 2019;34(1):156–162.
    OpenUrl
  19. 19.↵
    1. Luo D,
    2. Wan X,
    3. Liu J,
    4. Tong T
    . Optimally estimating the sample mean from the sample size, median, mid-range, and/or mid-quartile range. Stat Methods Med Res 2018;27(6):1785–1805.
    OpenUrl
  20. 20.↵
    1. Wan X,
    2. Wang W,
    3. Liu J,
    4. Tong T
    . Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol 2014;14:135.
    OpenUrlCrossRefPubMed
  21. 21.↵
    1. Higgins J,
    2. Green S
    . Cochrane handbook for systematic reviews of intervensions. 5.1.0. The Cochrane Collaboration. Available at: http://handbook.cochrane.org. Accessed on January 8, 2020.
  22. 22.↵
    1. Barraud D,
    2. Blard C,
    3. Hein F,
    4. Marçon O,
    5. Cravoisy A,
    6. Nace L,
    7. et al
    . Probiotics in the critically ill patient: a double blind, randomized, placebo-controlled trial. Intensive Care Med 2010;36(9):1540–1547.
    OpenUrlCrossRefPubMedWeb of Science
  23. 23.↵
    1. Forestier C,
    2. Guelon D,
    3. Cluytens V,
    4. Gillart T,
    5. Sirot J,
    6. De Champs C
    . Oral probiotic and prevention of Pseudomonas aeruginosa infections: a randomized, double-blind, placebo-controlled pilot study in intensive care unit patients. Crit Care 2008;12(3):R69.
    OpenUrlCrossRefPubMed
  24. 24.↵
    1. Knight DJ,
    2. Gardiner D,
    3. Banks A,
    4. Snape SE,
    5. Weston VC,
    6. Bengmark S,
    7. Girling KJ
    . Effect of synbiotic therapy on the incidence of ventilator associated pneumonia in critically ill patients: a randomised, double-blind, placebo-controlled trial. Intensive Care Med 2009;35(5):854–861.
    OpenUrlCrossRefPubMedWeb of Science
  25. 25.↵
    1. Oudhuis GJ,
    2. Bergmans DC,
    3. Dormans T,
    4. Zwaveling JH,
    5. Kessels A,
    6. Prins MH,
    7. et al
    . Probiotics versus antibiotic decontamination of the digestive tract: infection and mortality. Intensive Care Med 2011;37(1):110–117.
    OpenUrlCrossRefPubMedWeb of Science
  26. 26.↵
    1. Weng H,
    2. Li JG,
    3. Mao Z,
    4. Feng Y,
    5. Wang CY,
    6. Ren XQ,
    7. Zeng XT
    . Probiotics for preventing ventilator-associated pneumonia in mechanically ventilated patients: a meta-analysis with trial sequential analysis. Front Pharmacol 2017;8:717.
    OpenUrl
  27. 27.↵
    1. Rongrungruang Y,
    2. Krajangwittaya D,
    3. Pholtawornkulchai K,
    4. Tiengrim S,
    5. Thamlikitkul V
    . Randomized controlled study of probiotics containing Lactobacillus casei (Shirota strain) for prevention of ventilator-associated pneumonia. J Med Assoc Thai 2015;98(3):253–259.
    OpenUrlPubMed
  28. 28.↵
    1. Tan M,
    2. Zhu JC,
    3. Du J,
    4. Zhang LM,
    5. Yin HH
    . Effects of probiotics on serum levels of Th1/Th2 cytokine and clinical outcomes in severe traumatic brain-injured patients: a prospective randomized pilot study. Crit Care 2011;15(6):R290.
    OpenUrlCrossRefPubMed
  29. 29.↵
    1. Bo L,
    2. Li J,
    3. Tao T,
    4. Bai Y,
    5. Ye X,
    6. Hotchkiss RS,
    7. et al
    . Probiotics for preventing ventilator-associated pneumonia. Cochrane Database of Syst Rev 2014;(10):CD009066.
  30. 30.↵
    1. Siempos II,
    2. Ntaidou Tk,
    3. Falagas ME
    . Impact of the administration of probiotics on the incidence of ventilator-associated pneumonia: a meta-analysis of randomized controlled trials. Crit Care Med 2010;38(3):954–962.
    OpenUrlCrossRefPubMedWeb of Science
  31. 31.↵
    1. Banupriya B,
    2. Biswal N,
    3. Srinivasaraghavan R,
    4. Narayanan P,
    5. Mandal J
    . Probiotic prophylaxis to prevent ventilator associated pneumonia (VAP) in children on mechanical ventilation: an open-label randomized controlled trial. Intensive Care Med 2015;41(4):677–685.
    OpenUrl
  32. 32.↵
    1. Li XC,
    2. Wang JZ,
    3. Liu YH
    . Effect of probiotics on respiratory tract pathogen colonization in neonates undergoing mechanical ventilation [in Chinese with English abstract]. Zhongguo Dang Dai Er Ke Za Zhi 2012;14(6):406–408.
    OpenUrlPubMed
  33. 33.↵
    1. Wang J,
    2. Liu X,
    3. Ariani F,
    4. Tao LL,
    5. Zhang J,
    6. Qu JM
    . Probiotics for preventing ventilator-associated pneumonia: a systematic review and meta-analysis of high-quality randomized controlled trials. PloS One 2013;8(12):e83934.
    OpenUrl
  34. 34.↵
    1. Gill HS,
    2. Guarner F
    . Probiotics and human health: a clinical perspective. Postgrad Med J 2004;80(947):516–526.
    OpenUrlAbstract/FREE Full Text
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