Development of a Web-Based Tool Built From Pharmacy Claims Data to Assess Adherence to Respiratory Medications in Primary Care

References

1. 1.↵
   GBD 2015 Chronic Respiratory Disease Collaborators. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma. 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Respir Med 2015;5(9):691–706.

   OpenUrl
2. 2.↵
   Global Initiative for Asthma. Pocket Guide for Asthma Management and Prevention. Available at: https://ginasthma.org/pocket-guide-for-asthma-management-and-prevention. Accessed February 27, 2020.
3. 3.↵
   World Health Organization. Burden of COPD. Available at: https://www.who.int/respiratory/copd/burden/en. Accessed February 27, 2020.
4. 4.↵
   1. George M

   . Adherence in asthma and COPD: new strategies for an old problem. Respir Care 2018;63(6):818–831.

   OpenUrlAbstract/FREE Full Text
5. 5.↵
   1. Blais L,
   2. Kettani FZ,
   3. Forget A,
   4. Beauchesne MF,
   5. Lemière C,
   6. Ducharme FM

   . Assessing adherence to inhaled corticosteroids in asthma patients using an integrated measure based on primary and secondary adherence. Eur J Clin Pharmacol 2017;73(1):91–97.

   OpenUrl
6. 6.
   1. Humenberger M,
   2. Horner A,
   3. Labek A,
   4. Kaiser B,
   5. Frechinger R,
   6. Brock C,
   7. et al

   . Adherence to inhaled therapy and its impact on chronic obstructive pulmonary disease (COPD). BMC Pulm Med 2018;18(1):163.

   OpenUrl
7. 7.↵
   1. Savaria F,
   2. Beauchesne MF,
   3. Forget A,
   4. Blais L

   . Adherence and persistence to long-acting anticholinergics treatment episodes in patients with chronic obstructive pulmonary disease. Ann Pharmacother 2017;51(12):1063–1068.

   OpenUrl
8. 8.↵
   1. Ismaila AS,
   2. Sayani AP,
   3. Marin M,
   4. Su Z

   . Clinical, economic, and humanistic burden of asthma in Canada: a systematic review. BMC Pulm Med 2013;13:70–70.

   OpenUrlCrossRefPubMed
9. 9.↵
   1. Dang-Tan T,
   2. Ismaila A,
   3. Zhang S,
   4. Zarotsky V,
   5. Bernauer M

   . Clinical, humanistic, and economic burden of chronic obstructive pulmonary disease (COPD) in Canada: a systematic review. BMC Res Notes 2015;8:464–464.

   OpenUrlPubMed
10. 10.↵
    1. Dima AL,
    2. Hernandez G,
    3. Cunillera O,
    4. Ferrer M,
    5. de Bruin M

    , ASTRO-LAB Group. Asthma inhaler adherence determinants in adults: systematic review of observational data. Eur Respir J 2015;45(4):994–1018

    OpenUrlAbstract/FREE Full Text
11. 11.↵
    1. Pollard S,
    2. Bansback N,
    3. FitzGerld JM,
    4. Bryan S

    . The burden of nonadherence among adults with asthma: a role for shared decision-making. Allergy 2017;72(5):705–712.

    OpenUrl
12. 12.↵
    1. Bourbeau J,
    2. Bartlett SJ

    . Patient adherence in COPD. Thorax 2008;63(9):831–838.

    OpenUrlAbstract/FREE Full Text
13. 13.↵
    1. Kini V,
    2. Ho PM

    . Interventions to improve medication adherence: a review. JAMA 2018;320(23):2461–2473.

    OpenUrlPubMed
14. 14.↵
    1. Wechsler ME

    . Managing asthma in primary care: putting new guideline recommendations into context. Mayo Clin Proc 2009;84(8):707–717.

    OpenUrlCrossRefPubMedWeb of Science
15. 15.↵
    1. Broekhuizen BD,
    2. Sachs AP,
    3. Verheij TJ

    . COPD in primary care: from episodic to continual management. Br J Gen Pract 2012;62(595):60–61.

    OpenUrlFREE Full Text
16. 16.↵
    Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for the Diagnosis, Management, and Prevention of COPD. Available at: https://goldcopd.org. Accessed February 27, 2020.
17. 17.↵
    1. Jimmy B,
    2. Jose J

    . Patient medication adherence: measures in daily practice. Oman Med J 2011;26(3):155–159.

    OpenUrl
18. 18.↵
    1. Lim KG,
    2. Rank MA,
    3. Li JT,
    4. Patel A,
    5. Volcheck GW,
    6. Branda ME,
    7. et al

    . How well does patient self-report predict asthma medication possession? Implications for medication reconciliation and adherence assessment. J Asthma 2010;47(8):878–882.

    OpenUrlPubMed
19. 19.↵
    1. Martin LR,
    2. Williams SL,
    3. Haskard KB,
    4. DiMatteo MR

    . The challenge of patient adherence. Ther Clin Risk Manag 2005;1(3):189–199.

    OpenUrlPubMed
20. 20.↵
    1. Sherman J,
    2. Hutson A,
    3. Baumstein S,
    4. Hendeles L

    . Telephoning the patient's pharmacy to assess adherence with asthma medications by measuring refill rate for prescriptions. J Pediatr 2000;136(4):532–536.

    OpenUrlCrossRefPubMedWeb of Science
21. 21.↵
    1. Cadarette SM,
    2. Wong L

    . An introduction to health care administrative data. Can J Hosp Pharm 2015;68(3):232–237.

    OpenUrl
22. 22.↵
    1. Harbig P,
    2. Barat I,
    3. Lund Nielsen P,
    4. Damsgaard EM

    . Instantaneous detection of nonadherence: quality, strength, and weakness of an electronic prescription database. Pharmacoepidemiol Drug Saf 2012;21(3):323–328.

    OpenUrlCrossRefPubMed
23. 23.
    1. Heisler M,
    2. Hogan MM,
    3. Hofer TP,
    4. Schmittdiel JA,
    5. Pladevall M,
    6. Kerr EA

    . When more is not better: treatment intensification among hypertensive patients with poor medication adherence. Circulation 2008;117(22):2884–2892.

    OpenUrlAbstract/FREE Full Text
24. 24.
    1. Williams LK,
    2. Peterson EL,
    3. Wells K,
    4. Campbell J,
    5. Wang M,
    6. Chowdhry VK,
    7. et al

    . A cluster-randomized trial to provide clinicians inhaled corticosteroid adherence information for their patients with asthma. J Allergy Clin Immunol 2010;126(2):225–231.231.

    OpenUrlCrossRefWeb of Science
25. 25.
    1. Vollmer WM,
    2. Feldstein A,
    3. Smith DH,
    4. Dubanoski JP,
    5. Waterbury A,
    6. Schneider JL,
    7. et al

    . Use of health information technology to improve medication adherence. Am J Manag Care 2011;17(12 Spec No):SP79–SP87.

    OpenUrlPubMed
26. 26.↵
    1. Dixon BE,
    2. Alzeer AH,
    3. Phillips EO,
    4. Marrero DG

    . Integration of provider, pharmacy, and patient-reported data to improve medication adherence for type 2 diabetes: a controlled before-after pilot study. JMIR Med Inform 2016;4(1):e4.

    OpenUrl
27. 27.↵
    1. Comer D,
    2. Couto J,
    3. Aguiar R,
    4. Wu P,
    5. Elliott D

    . Using aggregated pharmacy claims to identify primary nonadherence. Am J Manag Care 2015;21(12):e655–660.

    OpenUrl
28. 28.↵
    Government of Canada. Dossier Santé Québec. Available at: https://www.quebec.ca/sante/vos-informations-de-sante/dossier-sante-quebec. Accessed February 27, 2020.
29. 29.↵
    1. Colorafi KJ,
    2. Evans B

    . Qualitative descriptive methods in health science research. HERD 2016;9(4):16–25.

    OpenUrlCrossRefPubMed
30. 30.↵
    1. Garrett JJ

    . The elements of user experience: user-centered design for the web and beyond. London: Pearson Education; 2010.
31. 31.↵
    1. Green J,
    2. Thorogood N

    . Qualitative methods for health research. Thousand Oaks, CA: Sage; 2014.
32. 32.↵
    1. Gubrium JF,
    2. Holstein JA

    1. Poland BD

    . Transcription quality. In: Gubrium JF, Holstein JA, editors. Handbook of interview research. Thousand Oaks, CA: Sage; 2002:629–650.
33. 33.↵
    1. Attride-Stirling J

    . Thematic networks: an analytic tool for qualitative research. Qual Res 2001;1(3):385–405.

    OpenUrlCrossRef
34. 34.↵
    1. Braun V,
    2. Clarke V

    . Using thematic analysis in psychology. Qual Res Psychol 2006;3(2):77–101.

    OpenUrlCrossRef
35. 35.↵
    1. Vaismoradi M,
    2. Jones J,
    3. Turunen H,
    4. Snelgrove S

    . Theme development in qualitative content analysis and thematic analysis. J Nurs Educ Pract 2016;6(5):100–110.

    OpenUrl
36. 36.↵
    1. Saunders B,
    2. Sim J,
    3. Kingstone T,
    4. Baker S,
    5. Waterfield J,
    6. Bartlam B,
    7. et al

    . Saturation in qualitative research: exploring its conceptualization and operationalization. Qual Quant 2018;52(4):1893–1907.

    OpenUrlCrossRefPubMed
37. 37.↵
    1. Guest G,
    2. Bunce A,
    3. Johnson L

    . How many interviews are enough? An experiment with data saturation and variability. Field Meth 2006;18(1):59–82.

    OpenUrlCrossRef
38. 38.↵
    RQRM. reMed: Data Registry for Prescribed Medications/Banque de données sur les médicaments d'ordonnance. Available at: http://www.rqrm.ca/plateformes/optimisation-de-l-usage/64-4-remed-data-registry-for-prescribed-medications-banque-de-donnees-sur-les-medicaments-d-ordonnance.html. Accessed February 27, 2020.
39. 39.↵
    1. Gross NJ,
    2. Barnes PJ

    . New therapies for asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2017;195(2):159–166.

    OpenUrlCrossRefPubMed
40. 40.↵
    1. Quantin C,
    2. Coatrieux G,
    3. Fassa M,
    4. Breton V,
    5. Jaquet-Chiffelle DO,
    6. de Vlieger P,
    7. et al

    . Centralised versus decentralised management of patients' medical records. Stud Health Technol Inform 2009;150:700–704.

    OpenUrlPubMed
41. 41.↵
    1. Nau DP

    . Proportion of days covered (PDC) as a preferred method of measuring medication adherence. Springfield, VA: Pharmacy Quality Alliance; 2012.
42. 42.↵
    1. Blais L,
    2. Beauchesne MF,
    3. Rey E,
    4. Malo JL,
    5. Forget A

    . Use of inhaled corticosteroids during the first trimester of pregnancy and the risk of congenital malformations among women with asthma. Thorax 2007;62(4):320–328.

    OpenUrlAbstract/FREE Full Text
43. 43.↵
    1. Martel M-J,
    2. Rey É,
    3. Beauchesne M-F,
    4. Perreault S,
    5. Lefebvre G,
    6. Forget A,
    7. et al

    . Use of inhaled corticosteroids during pregnancy and risk of pregnancy induced hypertension: nested case-control study. BMJ 2005;330(7485):230.

    OpenUrlAbstract/FREE Full Text
44. 44.↵
    1. Boulet L-P,
    2. Becker A,
    3. Bérubé D,
    4. Beveridge R,
    5. Ernst P

    . Summary of recommendations from the Canadian asthma consensus report. CMAJ 1999;161(11 Suppl):S1–S12.

    OpenUrlAbstract/FREE Full Text
45. 45.↵
    1. Blais L,
    2. Beauchesne M-F,
    3. Lévesque S

    . Socioeconomic status and medication prescription patterns in pediatric asthma in Canada. J Adolesc Health 2006;38(5):607.e609–.e616.

    OpenUrl
46. 46.↵
    1. Reddel HK,
    2. Bateman ED,
    3. Becker A,
    4. Boulet L-P,
    5. Cruz AA,
    6. Drazen JM,
    7. et al

    . A summary of the new GINA strategy: a roadmap to asthma control. Eur Respir J 2015;46(3):622–639.

    OpenUrlAbstract/FREE Full Text
47. 47.↵
    1. Lareau SC,
    2. Yawn BP

    . Improving adherence with inhaler therapy in COPD. Int J Chron Obstruct Pulmon Dis 2010;5:401–406.

    OpenUrlCrossRefPubMed
48. 48.↵
    1. Kerse N,
    2. Buetow S,
    3. Mainous AG 3rd.,
    4. Young G,
    5. Coster G,
    6. Arroll B

    . Physician-patient relationship and medication compliance: a primary care investigation. Ann Fam Med 2004;2(5):455–461.

    OpenUrlAbstract/FREE Full Text
49. 49.
    1. Stavropoulou C

    . Non-adherence to medication and doctor-patient relationship: evidence from a European survey. Patient Educ Couns 2011;83(1):7–13.

    OpenUrlCrossRefPubMed
50. 50.↵
    1. Tarn DM,
    2. Mattimore TJ,
    3. Bell DS,
    4. Kravitz RL,
    5. Wenger NS

    . Provider views about responsibility for medication adherence and content of physician-older patient discussions. J Am Geriatr Soc 2012;60(6):1019–1026.

    OpenUrlCrossRefPubMed
51. 51.↵
    1. McKendry R,
    2. Haggerty J

    . Defusing the confusion: concepts and measures of continuity of health care. Ottawa, Canada: Canadian Foundation for Healthcare Improvement; 2002.
52. 52.↵
    1. Yousif A,
    2. Lemière C,
    3. Cartier A,
    4. Forget A,
    5. Blais L

    . Development of a graphical tool to measure medication adherence in asthma patients: a mixed-methods pilot study. J Asthma 2019;56(5):543–552.

    OpenUrl
53. 53.↵
    1. Morse JM,
    2. Barrett M,
    3. Mayan M,
    4. Olson K,
    5. Spiers J

    . Verification strategies for establishing reliability and validity in qualitative research. Int J Qual Methods 2002;1(2):13–22.

    OpenUrl