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Meeting ReportAerosol and Oxygen Therapy

Evaluation of Aerosol Delivery Through an Oxygen Hood With Different Aerosol Inlet

Shu-Hsin Chen, Hsiu-Chu Chang and Hui-Ling Lin
Respiratory Care October 2021, 66 (Suppl 10) 3604147;
Shu-Hsin Chen
Respiratory Therapy, Keelung Chang Gung Memorial Hospital, New Taipei City, Taiwan
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Hsiu-Chu Chang
Respiratory Therapy, Keelung Chang Gung Memorial Hospital, New Taipei City, Taiwan
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Hui-Ling Lin
Department of Respiratory Therapy, Chang Gung University, Taoyuan City, Taiwan
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Abstract

Background: Aerosol delivery to infants and children is a challenge due to their intolerance of the interface of a jet nebulizer. The effectiveness of aerosol delivery through an oxygen hood to infants has been proven. Yet, the influence of hood design and breath pattern on the aerosolized drug dose is not well explored. This study aimed to evaluated nebulized drug delivered through a facemask vs. a hood with infant and toddler breath pattern.

Methods: A breathing simulation (ASL 5000, Ingmar Medical Inc.) was used to generate infant (VT 50 mL, respiratory rate 33 b/min, flow 13.1 L/min) and toddler (VT 100 mL, respiratory rate 24 b/min, flow 14.5 L/min) breath patterns, and connected to either an infant or a child intubation mannequin. A bacterial filter was placed between the ASL 5000 and the bronchi of the mannequin to collect aerosolized drug particles. A united-dose of salbutamol (5 mg/2.5 mL) was placed in a small volume nebulizer (Galmed Inc., Taiwan) and diluted to 4 mL. The nebulizer was connected either to a pediatric facemask or a customized infant oxygen hood (22 x 25.5 x 20 cm), or a child oxygen hood (36 x 33 x 27 cm) with and without a cover, and a hole with 2.5 cm diameter at the center of the top, back, and side. Drug mass deposited in the filter and on the face of the mannequin was analyzed by UV spectrophotometry at 276 nm wavelength (n = 5). Statistical analyses were performed with ANOVA and Scheffe post hoc test, with a significance level of P < 0.05.

Results: Table 1 below illustrates comparisons between the inhaled drug dose and face dose between infant and child breath patterns. The inhaled dose was significantly greater with an oxygen hood and the nebulizer at the back for infant breath pattern, and with a facemask for toddler breath pattern (P < 0.001).

Conclusions: Aerosol delivery through an oxygen hood, with the nebulizer placed at the center of the back of the hood, is effective in the infant model. A facemask was more effective for toddler breath patterns.

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Comparison of inhaled and face drug doses with two breath pattern (mean±SD)

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Respiratory Care
Vol. 66, Issue Suppl 10
1 Oct 2021
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Evaluation of Aerosol Delivery Through an Oxygen Hood With Different Aerosol Inlet
Shu-Hsin Chen, Hsiu-Chu Chang, Hui-Ling Lin
Respiratory Care Oct 2021, 66 (Suppl 10) 3604147;

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Evaluation of Aerosol Delivery Through an Oxygen Hood With Different Aerosol Inlet
Shu-Hsin Chen, Hsiu-Chu Chang, Hui-Ling Lin
Respiratory Care Oct 2021, 66 (Suppl 10) 3604147;
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