Skip to main content
 

Main menu

  • Home
  • Content
    • Current Issue
    • Editor's Commentary
    • Coming Next Month
    • Archives
    • Most-Read Papers of 2021
  • Authors
    • Author Guidelines
    • Submit a Manuscript
  • Reviewers
    • Reviewer Information
    • Create Reviewer Account
    • Reviewer Guidelines: Original Research
    • Reviewer Guidelines: Reviews
    • Appreciation of Reviewers
  • CRCE
    • Through the Journal
    • JournalCasts
    • AARC University
    • PowerPoint Template
  • Open Forum
    • 2022 Call for Abstracts
    • 2021 Abstracts
    • Previous Open Forums
  • Podcast
    • English
    • Español
    • Portugûes
    • 国语
  • Videos
    • Video Abstracts
    • Author Interviews
    • Highlighted Articles
    • The Journal

User menu

  • Subscribe
  • My alerts
  • Log in

Search

  • Advanced search
American Association for Respiratory Care
  • Subscribe
  • My alerts
  • Log in
American Association for Respiratory Care

Advanced Search

  • Home
  • Content
    • Current Issue
    • Editor's Commentary
    • Coming Next Month
    • Archives
    • Most-Read Papers of 2021
  • Authors
    • Author Guidelines
    • Submit a Manuscript
  • Reviewers
    • Reviewer Information
    • Create Reviewer Account
    • Reviewer Guidelines: Original Research
    • Reviewer Guidelines: Reviews
    • Appreciation of Reviewers
  • CRCE
    • Through the Journal
    • JournalCasts
    • AARC University
    • PowerPoint Template
  • Open Forum
    • 2022 Call for Abstracts
    • 2021 Abstracts
    • Previous Open Forums
  • Podcast
    • English
    • Español
    • Portugûes
    • 国语
  • Videos
    • Video Abstracts
    • Author Interviews
    • Highlighted Articles
    • The Journal
  • Twitter
  • Facebook
  • YouTube
Meeting ReportAerosol and Oxygen Therapy

Multidrug Aerosol Delivery During Mechanical Ventilation

Ann D Cuccia, Janice A Lee, Michael McPeck and Gerald C Smaldone
Respiratory Care October 2021, 66 (Suppl 10) 3606671;
Ann D Cuccia
Respiratory Care Program, Stony Brook University, Stony Brook, New York, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Janice A Lee
Division of Pulmonary, Critical Care & Sleep Medicine, State University of New York at Stony Brook, Stony Brook, New York, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael McPeck
Division of Pulmonary, Critical Care & Sleep Medicine, State University of New York at Stony Brook, Stony Brook, New York, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gerald C Smaldone
Division of Pulmonary, Critical Care & Sleep Medicine, State University of New York at Stony Brook, Stony Brook, New York, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • References
  • Info & Metrics
Loading

Abstract

Background: Continuous nebulization of pulmonary vasodilators is an off-label therapy for hypoxemia. Patients may require additional aerosol therapies such as bronchodilators and antibiotics. This study evaluates delivery of concurrent therapy of multiple medications during continuous nebulization without interruption or circuit disconnection.

Methods: One i-AIRE dual-port breath-enhanced jet nebulizer (BEJN) or two Aerogen Solo vibrating mesh nebulizers (VMN) were installed on the dry side of the humidifier. VMN were stacked; one for infusion, the second for bolus drug delivery. The BEJN was powered by air at 3.5 L/min, 50 psig. Radiolabeled saline was infused at 5 & 10 mL/h with radiolabeled 3 mL and 6 mL bolus injections at 30 and 120 min respectively. Two adult breathing patterns (duty cycle 0.13 and 0.34) were tested with an infusion time of 4 h. Inhaled Mass expressed as % of initial syringe activity (IM %/min) was monitored in real time with a ratemeter. All delivered radioaerosol was collected on a filter at the airway opening. Transients in aerosol delivery were documented.

Results: IM %/h during continuous infusion was linear and predictable, mean ± SD: 3.63 ± 2.02%, 3.54 ± 2.78% for BEJN and VMN, respectively. BEJN functioned without incident. VMN continuous aerosol delivery stopped spontaneously in 4 of 8 runs (50%); bolus delivery stopped spontaneously in 9 of 16 runs (56%). Tapping restarted VMN function during 3 of 4 continuous runs and 7 of 9 bolus delivery runs. Bolus delivery IM% (mean ± SD): 22.17 ± 7.65%, 14.37 ± 10.62% for BEJN and VMN, respectively.

Conclusions: Simultaneous continuous and bolus nebulization without circuit disconnection is possible for both jet and mesh technology. Monitoring of VMN devices may be necessary in case of spontaneous interruption of nebulization.

Footnotes

  • Commercial Relationships: DISCLOSURES: Mr. McPeck and Dr. Lee: no disclosures. Ms. Cuccia is a consultant to InspiRx. Dr. Smaldone serves as a consultant and member of the advisory board of InspiRx Inc. Stony Brook University holds patents licensed to InspiRx, Inc.

  • Support: InspiRx, Inc. Somerset, NJ.

  • Copyright © 2021 by Daedalus Enterprises
PreviousNext
Back to top

In this issue

Respiratory Care
Vol. 66, Issue Suppl 10
1 Oct 2021
  • Table of Contents
  • Index by author

 

Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on American Association for Respiratory Care.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Multidrug Aerosol Delivery During Mechanical Ventilation
(Your Name) has sent you a message from American Association for Respiratory Care
(Your Name) thought you would like to see the American Association for Respiratory Care web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Multidrug Aerosol Delivery During Mechanical Ventilation
Ann D Cuccia, Janice A Lee, Michael McPeck, Gerald C Smaldone
Respiratory Care Oct 2021, 66 (Suppl 10) 3606671;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Multidrug Aerosol Delivery During Mechanical Ventilation
Ann D Cuccia, Janice A Lee, Michael McPeck, Gerald C Smaldone
Respiratory Care Oct 2021, 66 (Suppl 10) 3606671;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • References

Related Articles

Cited By...

Info For

  • Subscribers
  • Institutions
  • Advertisers

About Us

  • About the Journal
  • Editorial Board
  • Reprints/Permissions

AARC

  • Membership
  • Meetings
  • Clinical Practice Guidelines

More

  • Contact Us
  • RSS
American Association for Respiratory Care

Print ISSN: 0020-1324        Online ISSN: 1943-3654

© Daedalus Enterprises, Inc.

Powered by HighWire