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Abstract
BACKGROUND: There is limited evidence on the clinical importance of the endotracheal tube (ETT) size selection in patients with status asthmaticus who require invasive mechanical ventilation. We set out to explore the clinical outcomes of different ETT internal diameter sizes in subjects mechanically ventilated with status asthmaticus.
METHODS: This was a retrospective study of intubated and non-intubated adults admitted for status asthmaticus between 2014–2021. We examined in-hospital mortality across subgroups with different ETT sizes, as well as non-intubated subjects, using logistic and generalized linear mixed-effects models. We adjusted for demographics, Charlson comorbidities, the first Sequential Organ Failure Assessment score, intubating personnel and setting, COVID-19, and the first PaCO2. Finally, we calculated the post-estimation predictions of mortality.
RESULTS: We enrolled subjects from 964 status asthmaticus admissions. The average age was 46.9 (SD 14.5) y; 63.5% of the encounters were women and 80.6% were Black. Approximately 72% of subjects (690) were not intubated. Twenty-eight percent (275) required endotracheal intubation, of which 3.3% (32) had a 7.0 mm or smaller ETT (ETT ≤ 7 group), 16.5% (159) a 7.5 mm ETT (ETT ≤ 7.5 group), and 8.6% (83) an 8.0 mm or larger ETT (ETT ≥ 8 group). The adjusted mortality was 26.7% (95% CI 13.2–40.2) for the ETT ≤ 7 group versus 14.3% ([(95% CI 6.9–21.7%], P = .04) for ETT ≤ 7.5 group and 11.0% ([95% CI 4.4–17.5], P = .02) for ETT ≥ 8 group, respectively.
CONCLUSIONS: Intubated subjects with status asthmaticus had higher mortality than non-intubated subjects. Intubated subjects had incrementally higher observed mortality with smaller ETT sizes. Physiologic mechanisms can support this dose-response relationship
Footnotes
- Correspondence: Markos G Kashiouris MD MPH, Division of Pulmonary and Critical Care, Virginia Commonwealth University, PO Box 980509, Richmond, VA 23298. E-mail: mkashiouris{at}vcu.edu
See the Related Editorial on Page 373
The authors have disclosed no conflicts of interest.
The study was supported by a VCU Wright Center for Translational Science Award (UL1TR000058), Division of Pulmonary Disease and Critical Care Medicine, VCU School of Medicine.
- Copyright © 2022 by Daedalus Enterprises
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