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Research ArticleOriginal Research

Time to Extubation Among ARDS Subjects With and Without COVID-19 Pneumonia

Gregory D Burns, Justin S Phillips, Richard H Kallet, David V Glidden, Carolyn M Hendrickson and John Z Metcalfe
Respiratory Care October 2023, 68 (10) 1340-1346; DOI: https://doi.org/10.4187/respcare.09876
Gregory D Burns
Respiratory Care Division, Department of Anesthesia and Perioperative Care, University of California, San Francisco at Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California.
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  • For correspondence: [email protected]
Justin S Phillips
Respiratory Care Division, Department of Anesthesia and Perioperative Care, University of California, San Francisco at Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California.
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Richard H Kallet
Department of Anesthesia and Perioperative Care, University of California, San Francisco at San Francisco General Hospital, San Francisco, California.
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David V Glidden
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California
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Carolyn M Hendrickson
Division of Pulmonary and Critical Care Medicine, University of California, San Francisco at Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California.
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John Z Metcalfe
Division of Pulmonary and Critical Care Medicine, University of California, San Francisco at Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California.
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Abstract

BACKGROUND: Pneumonia from COVID-19 that results in ARDS may require invasive mechanical ventilation. This retrospective study assessed the characteristics and outcomes of subjects with COVID-19–associated ARDS versus ARDS (non-COVID) during the first 6 months of the COVID-19 pandemic in 2020. The primary objective was to determine whether mechanical ventilation duration differed between these cohorts and identify other potential contributory factors.

METHODS: We retrospectively identified 73 subjects admitted between March 1 and August 12, 2020, with either COVID-19–associated ARDS (37) or ARDS (36) who were managed with the lung protective ventilator protocol and required >48 h of mechanical ventilation. Exclusion criteria were the following: <18 years old or the patient required tracheostomy or interfacility transfer. Demographic and baseline clinical data were collected at ARDS onset (ARDS day 0), with subsequent data collected on ARDS days 1–3, 5, 7, 10, 14, and 21. Comparisons were made by using the Wilcoxon rank-sum test (continuous variables) and chi-square test (categorical variables) stratified by COVID-19 status. A Cox proportional hazards model assessed the cause-specific hazard ratio for extubation.

RESULTS: The median (interquartile range) mechanical ventilation duration among the subjects who survived to extubation was longer in those with COVID-19-ARDS versus the subjects with non-COVID ARDS: 10 (6–20) d versus 4 (2–8) d; P < .001. Hospital mortality was not different between the two groups (22% vs 39%; P = .11). The competing risks Cox proportional hazard analysis (fit among the total sample, including non-survivors) revealed that improved compliance of the respiratory system and oxygenation were associated with the probability of extubation. Oxygenation improved at a lower rate in the subjects with COVID-19–associated ARDS than in the subjects with non-COVID ARDS.

CONCLUSIONS: Mechanical ventilation duration was longer in subjects with COVID-19–associated ARDS compared with the subjects with non-COVID ARDS, which may be explained by a lower rate of improvement in oxygenation status.

  • Extubation
  • weaning
  • Corona Virus Disease 2019
  • acute respiratory distress syndrome

Footnotes

  • Correspondence: Gregory D Burns MAS RRT, Respiratory Care Division, Department of Anesthesia and Perioperative Care,University of California, San Francisco at Zuckerberg San Francisco General Hospital and Trauma Center, 1001 Potrero Ave, San Francisco, CA 94110. E-mail: Gregory.burns{at}ucsf.edu
  • Mr Kallet discloses relationships with ContinuED, Lungpacer Medical, and the Asthma & Allergy Prevention Company. Mr Phillips discloses relationships with ContinuED and Saxe Communications. The other authors have disclosed no conflicts of interest.

  • See the Related Editorial on Page 1475

  • Copyright © 2023 by Daedalus Enterprises
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Respiratory Care: 68 (10)
Respiratory Care
Vol. 68, Issue 10
1 Oct 2023
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Time to Extubation Among ARDS Subjects With and Without COVID-19 Pneumonia
Gregory D Burns, Justin S Phillips, Richard H Kallet, David V Glidden, Carolyn M Hendrickson, John Z Metcalfe
Respiratory Care Oct 2023, 68 (10) 1340-1346; DOI: 10.4187/respcare.09876

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Time to Extubation Among ARDS Subjects With and Without COVID-19 Pneumonia
Gregory D Burns, Justin S Phillips, Richard H Kallet, David V Glidden, Carolyn M Hendrickson, John Z Metcalfe
Respiratory Care Oct 2023, 68 (10) 1340-1346; DOI: 10.4187/respcare.09876
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Keywords

  • Extubation
  • weaning
  • Corona Virus Disease 2019
  • acute respiratory distress syndrome

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