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Abstract
Randomized controlled trials (RCTs) are considered to produce the highest level of evidence in the original studies that informs the practice of evidence-based medicine (EBM). By manipulating an independent variable to study its impact on the outcome, RCTs establish causal relationships and provide valuable insights into clinical treatment. To improve patient outcomes and optimize the use of clinical resources, the practice of EBM plays a crucial role in designing and conducting RCTs to evaluate the effectiveness of clinical interventions. This review aims to explore the essential steps involved in conducting a rigorous and reliable RCT, ensuring the generation of high-quality evidence.
Footnotes
- Correspondence: Jie Li PhD RRT RRT-ACCS RRT-NPS FAARC, 600 S Paulina Street, Suite 765, Chicago 60612, IL. E-mail: jie_li{at}rush.edu
Dr Li discloses relationships with Fisher & Paykel Healthcare, Aerogen, the Rice Foundation, the American Association for Respiratory Care, and Heyer. Dr Li is a section editor for Respiratory Care. Dr Kaur discloses relationship with American Association for Respiratory Care.
Dr Li presented a version of this paper at the symposium Research in Respiratory Care at AARC Congress 2022, held November 8, 2022, in New Orleans, Louisiana.
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