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Research ArticleOriginal Research

PEEP Generated by High-Flow Nasal Cannula in a Pediatric Model

Beverly D Ejiofor, Ryan W Carroll, William Bortcosh and Robert M Kacmarek
Respiratory Care May 2019, respcare.06470; DOI: https://doi.org/10.4187/respcare.06470
Beverly D Ejiofor
Massachusetts General Hospital, Boston, Massachusetts. Drs Carroll and Kacmarek are also affiliated with Harvard Medical School, Boston, Massachusetts.
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  • For correspondence: [email protected]
Ryan W Carroll
Massachusetts General Hospital, Boston, Massachusetts. Drs Carroll and Kacmarek are also affiliated with Harvard Medical School, Boston, Massachusetts.
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William Bortcosh
Massachusetts General Hospital, Boston, Massachusetts. Drs Carroll and Kacmarek are also affiliated with Harvard Medical School, Boston, Massachusetts.
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Robert M Kacmarek
Massachusetts General Hospital, Boston, Massachusetts. Drs Carroll and Kacmarek are also affiliated with Harvard Medical School, Boston, Massachusetts.
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Abstract

BACKGROUND: High-flow nasal cannulas (HFNC) have been increasingly used in the pediatric critical care patient population. There are different theories about the mechanism by which HFNC reduces work of breathing, including diminishing upper airway dead space by the washout of carbon dioxide. However, one of the likely primary mechanisms by which HFNC reduces work of breathing is by generating PEEP. There are limited data assessing the PEEP delivered by moderate flows (8 –50 L/min) of HFNC, which are used most commonly in pediatric patients.

METHODS: Pediatric upper-airway models were created with 5 different nares produced by a 3-dimensional printer and connected to a lung simulator. Age-specific flows were delivered via the 5 different setups. Pressure throughout the simulated airway was measured at HFNC flows of 6 – 60 L/min with 25%, 50%, and 75% air leak to simulate open-mouth breathing.

RESULTS: PEEPs of 1.2–36 cm H2O were generated with HFNC flows of 6 – 60 L/min. In general, for each specific cannula, increasing the flow and decreasing the air leak resulted in higher levels of PEEP delivered (P < .001 and > 10% difference). Changes in lung mechanics as generated by the lung simulator to simulate different patient ages resulted in the establishment of different levels of PEEP.

CONCLUSIONS: HFNCs deliver varying amounts of PEEP at the alveolar level with flows of 6 – 60 L/min. Increasing flow and decreasing leak resulted in the generation of greater PEEP. PEEP levels differed across cannulas and model weights at the same leak level, likely due to differences in the nasal interface between the HFNC device and the model nares.

  • noninvasive
  • ventilation
  • ventilation
  • high-flow nasal cannula
  • PEEP
  • child
  • pediatric intensive care units

Footnotes

  • Correspondence: Beverly D Ejiofor, Massachusetts General Hospital, Respiratory Care Services, 275 Cambridge Street, Boston, MA 02114. E-mail: bejiofor{at}partners.org
  • Dr Kacmarek has disclosed a relationship with Medtronic, Orange Medical, and Venner Medical. The other authors have disclosed no conflicts of interest.

  • Copyright © 2019 by Daedalus Enterprises
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Respiratory Care: 67 (7)
Respiratory Care
Vol. 67, Issue 7
1 Jul 2022
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PEEP Generated by High-Flow Nasal Cannula in a Pediatric Model
Beverly D Ejiofor, Ryan W Carroll, William Bortcosh, Robert M Kacmarek
Respiratory Care May 2019, respcare.06470; DOI: 10.4187/respcare.06470

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PEEP Generated by High-Flow Nasal Cannula in a Pediatric Model
Beverly D Ejiofor, Ryan W Carroll, William Bortcosh, Robert M Kacmarek
Respiratory Care May 2019, respcare.06470; DOI: 10.4187/respcare.06470
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Keywords

  • noninvasive
  • ventilation
  • high-flow nasal cannula
  • PEEP
  • child
  • pediatric intensive care units

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