@article {Azeredo333, author = {Leandro M Azeredo and S{\'e}rgio N Nemer and Carmen SV Barbas and Jefferson B Caldeira and Ros{\^a}ngela No{\'e} and Bruno L Guimar{\~a}es and C{\'e}lia P Caldas}, title = {The Integrative Weaning Index in Elderly ICU Subjects}, volume = {62}, number = {3}, pages = {333--339}, year = {2017}, doi = {10.4187/respcare.04524}, publisher = {Respiratory Care}, abstract = {BACKGROUND: With increasing life expectancy and ICU admission of elderly patients, mechanical ventilation, and weaning trials have increased worldwide.METHODS: We evaluated a cohort with 479 subjects in the ICU. Patients younger than 18 y, tracheostomized, or with neurologic diseases were excluded, resulting in 331 subjects. Subjects >=70 y old were considered elderly, whereas those \<70 y old were considered non-elderly. Besides the conventional weaning indexes, we evaluated the performance of the integrative weaning index (IWI). The probability of successful weaning was investigated using relative risk and logistic regression. The Hosmer-Lemeshow goodness-of-fit test was used to calibrate and the C statistic was calculated to evaluate the association between predicted probabilities and observed proportions in the logistic regression model.RESULTS: Prevalence of successful weaning in the sample was 83.7\%. There was no difference in mortality between elderly and non-elderly subjects (P = .16), in days of mechanical ventilation (P = .22) and days of weaning (P = .55). In elderly subjects, the IWI was the only respiratory variable associated with mechanical ventilation weaning in this population (P \< .001).CONCLUSIONS: The IWI was the independent variable found in weaning of elderly subjects that may contribute to the critical moment of this population in intensive care.}, issn = {0020-1324}, URL = {https://rc.rcjournal.com/content/62/3/333}, eprint = {https://rc.rcjournal.com/content/62/3/333.full.pdf}, journal = {Respiratory Care} }