RT Journal Article
SR Electronic
T1 Modeling of Lung Function Recovery in Neuralgic Amyotrophy With Diaphragm Impairment
JF Respiratory Care
FD American Association for Respiratory Care
SP respcare.05568
DO 10.4187/respcare.05568
A1 Brenda L Rice
A1 Rendell W Ashton
A1 Xiao-Feng Wang
A1 Steven J Shook
A1 Eduardo Mireles-Cabodevila
A1 Loutfi S Aboussouan
YR 2017
UL http://rc.rcjournal.com/content/early/2017/07/11/respcare.05568.abstract
AB BACKGROUND: Neuralgic amyotrophy is an inflammatory peripheral nerve disorder in which phrenic nerve involvement can lead to diaphragm paralysis. The prevalence, magnitude, and time course of diaphragm recovery are uncertain.METHODS: This study modeled the course of recovery of lung function in 16 subjects with diaphragm impairment from neuralgic amyotrophy. The first and last available vital capacity, sitting-to-supine decline in vital capacity, and maximal inspiratory pressures were compared.RESULTS: An asymptotic regression model analysis in 11 subjects with at least partial recovery provided estimates of the vital capacity at onset (47%, 95% CI 25–68%), the final vital capacity (81%, 95% CI 62–101%), and the half-time to recovery (22 months, 95% CI 15–43 months). In those subjects, there was a significant improvement between the first and last measured FVC (median 44–66%, P = .004) and maximal inspiratory pressure (mean 34–51%, P = .004). Five subjects (31%) with complete recovery had a final sitting-to-supine drop of vital capacity of 16% and a maximal predicted inspiratory pressure of 63%.CONCLUSION: Sixty-nine percent of subjects with diaphragm impairment from neuralgic amyotrophy experience recovery of lung function and diaphragm strength, but recovery is slow and may be incomplete.