RT Journal Article SR Electronic T1 Serum Albumin and Disease Severity of Non-Cystic Fibrosis Bronchiectasis JF Respiratory Care FD American Association for Respiratory Care SP 1075 OP 1084 DO 10.4187/respcare.05276 VO 62 IS 8 A1 Seung Jun Lee A1 Hyo-Jung Kim A1 Ju-Young Kim A1 Sunmi Ju A1 Sujin Lim A1 Jung Wan Yoo A1 Sung-Jin Nam A1 Gi Dong Lee A1 Hyun Seop Cho A1 Rock Bum Kim A1 Yu Ji Cho A1 Yi Yeong Jeong A1 Ho Cheol Kim A1 Jong Deog Lee YR 2017 UL http://rc.rcjournal.com/content/62/8/1075.abstract AB BACKGROUND: A clinical classification system has been developed to define the severity and predict the prognosis of subjects with non-cystic fibrosis (CF) bronchiectasis. We aimed to identify laboratory parameters that are correlated with the bronchiectasis severity index (BSI) and FACED score.METHODS: The medical records of 107 subjects with non-CF bronchiectasis for whom BSI and FACED scores could be calculated were retrospectively reviewed. The correlations between the laboratory parameters and BSI or FACED score were assessed, and multiple-linear regression analysis was performed to identify variables independently associated with BSI and FACED score. An additional subgroup analysis was performed according to sex.RESULTS: Among all of the enrolled subjects, 49 (45.8%) were male and 58 (54.2%) were female. The mean BSI and FACED scores were 9.43 ± 3.81 and 1.92 ± 1.59, respectively. The serum albumin level (r = −0.49), bilirubin level (r = −0.31), C-reactive protein level (r = 0.22), hemoglobin level (r = −0.2), and platelet/lymphocyte ratio (r = 0.31) were significantly correlated with BSI. Meanwhile, serum albumin (r = −0.37) and bilirubin level (r = −0.25) showed a significant correlation with the FACED score. Multiple-linear regression analysis showed that the serum bilirubin level was independently associated with BSI, and the serum albumin level was independently associated with both scoring systems. Subgroup analysis revealed that the level of uric acid was also a significant variable independently associated with the BSI in male bronchiectasis subjects.CONCLUSIONS: Several laboratory variables were identified as possible prognostic factors for non-CF bronchiectasis. Among them, the serum albumin level exhibited the strongest correlation and was identified as an independent variable associated with the BSI and FACED scores.