PT - JOURNAL ARTICLE AU - Morgan I Soffler AU - Margaret M Hayes AU - Richard M Schwartzstein TI - Respiratory Sensations in Dynamic Hyperinflation: Physiological and Clinical Applications AID - 10.4187/respcare.05198 DP - 2017 Sep 01 TA - Respiratory Care PG - 1212--1223 VI - 62 IP - 9 4099 - http://rc.rcjournal.com/content/62/9/1212.short 4100 - http://rc.rcjournal.com/content/62/9/1212.full AB - Dynamic hyperinflation is a common cause of dyspnea and functional limitation in patients with emphysema. Dynamic hyperinflation occurs in individuals with air-flow limitation when expiratory time is decreased during periods of relative tachypnea (such as during exercise or agitation, for example). In this setting, patients with emphysema develop lung hyperinflation, impairment of inspiratory respiratory muscles, and an increase in work of breathing. The associated decrease in inspiratory capacity results in the stimulation of several receptors, including chemoreceptors and pulmonary receptors, which signal the brain to increase tidal volume. The inability of the respiratory system to respond to signals of increased demand (eg, by enlarging tidal volume and increasing inspiratory flow) results in a dissociation between afferent and efferent signaling thereby intensifying breathing discomfort, or what clinicians term dyspnea. A thorough understanding of the physiology of dyspnea and pathophysiology of dynamic hyperinflation informs the interventions used to mitigate sensations of dyspnea and the physiologic effects of dynamic hyperinflation, respectively. Pharmacotherapy, pulmonary rehabilitation, breathing techniques, positive airway pressure, and lung volume reduction are well-studied interventions that target pathways to dyspnea in patients with dynamic hyperinflation.