TY - JOUR T1 - Modeling of Lung Function Recovery in Neuralgic Amyotrophy With Diaphragm Impairment JF - Respiratory Care SP - 1269 LP - 1276 DO - 10.4187/respcare.05568 VL - 62 IS - 10 AU - Brenda L Rice AU - Rendell W Ashton AU - Xiao-Feng Wang AU - Steven J Shook AU - Eduardo Mireles-Cabodevila AU - Loutfi S Aboussouan Y1 - 2017/10/01 UR - http://rc.rcjournal.com/content/62/10/1269.abstract N2 - BACKGROUND: Neuralgic amyotrophy is an inflammatory peripheral nerve disorder in which phrenic nerve involvement can lead to diaphragm paralysis. The prevalence, magnitude, and time course of diaphragm recovery are uncertain.METHODS: This study modeled the course of recovery of lung function in 16 subjects with diaphragm impairment from neuralgic amyotrophy. The first and last available vital capacity, sitting-to-supine decline in vital capacity, and maximal inspiratory pressures were compared.RESULTS: An asymptotic regression model analysis in 11 subjects with at least partial recovery provided estimates of the vital capacity at onset (47%, 95% CI 25–68%), the final vital capacity (81%, 95% CI 62–101%), and the half-time to recovery (22 months, 95% CI 15–43 months). In those subjects, there was a significant improvement between the first and last measured FVC (median 44–66%, P = .004) and maximal inspiratory pressure (mean 34–51%, P = .004). Five subjects (31%) with complete recovery had a final sitting-to-supine drop of vital capacity of 16% and a maximal predicted inspiratory pressure of 63%.CONCLUSIONS: Sixty-nine percent of subjects with diaphragm impairment from neuralgic amyotrophy experience recovery of lung function and diaphragm strength, but recovery is slow and may be incomplete. ER -