TY - JOUR T1 - A Method for Increasing Jet Nebulizer Delivery Efficiency for Aerosol Drug Delivery in Ventilated Newborns: An In Vitro Study JF - Respiratory Care SP - 1244 LP - 1250 VL - 51 IS - 11 AU - Michael C Quong AU - Bernard Thébaud AU - Warren H Finlay Y1 - 2006/11/01 UR - http://rc.rcjournal.com/content/51/11/1244.abstract N2 - BACKGROUND: A substantial percentage of the aerosol produced by a nebulizer is lost down the expiratory limb of the ventilator circuit. We describe a method for the capture, return, and reaerosolization of that undelivered aerosol. METHODS: We designed an expiratory-limb setup in which an “entraining jet” of gas accelerates unused aerosol and propels it toward an impaction surface. The deposited solution is then returned to the nebulizer reservoir via a feedback tube. As a result, more of the initial dose is delivered to the patient. The fraction of the dose delivered to a filter connected to a passive neonatal test lung was measured with and without the aerosol-recycling components activated. We used a ΔP (difference between the peak inspiratory pressure and the positive-end-expiratory pressure) of approximately 7.5 cm H2O, tidal volume of approximately 6 mL, respiratory rate of 40 breaths/min, and an inspiratory-expiratory ratio of 1:2.3. RESULTS: There was a statistically significant improvement with the feedback return to the reservoir, with up to nearly 60% more aerosol delivered. CONCLUSION: This improvement in aerosol delivery is encouraging, but more comprehensive studies are needed before such a device could be implemented clinically. ER -