RT Journal Article
SR Electronic
T1 High-Frequency Oscillatory Ventilation Use and Severe Pediatric ARDS in the Pediatric Hematopoietic Cell Transplant Recipient
JF Respiratory Care
FD American Association for Respiratory Care
SP 404
OP 411
DO 10.4187/respcare.05765
VO 63
IS 4
A1 Courtney M Rowan
A1 Ashley Loomis
A1 Jennifer McArthur
A1 Lincoln S Smith
A1 Shira J Gertz
A1 Julie C Fitzgerald
A1 Mara E Nitu
A1 Elizabeth AS Moser
A1 Deyin D Hsing
A1 Christine N Duncan
A1 Kris M Mahadeo
A1 Jerelyn Moffet
A1 Mark W Hall
A1 Emily L Pinos
A1 Robert F Tamburro
A1 Ira M Cheifetz
A1 the Investigators of the Pediatric Acute Lung Injury and Sepsis Network
YR 2018
UL http://rc.rcjournal.com/content/63/4/404.abstract
AB INTRODUCTION: The effectiveness of high-frequency oscillatory ventilation (HFOV) in the pediatric hematopoietic cell transplant patient has not been established. We sought to identify current practice patterns of HFOV, investigate parameters during HFOV and their association with mortality, and compare the use of HFOV to conventional mechanical ventilation in severe pediatric ARDS.METHODS: This is a retrospective analysis of a multi-center database of pediatric and young adult allogeneic hematopoietic cell transplant subjects requiring invasive mechanical ventilation for critical illness from 2009 through 2014. Twelve United States pediatric centers contributed data. Continuous variables were compared using a Wilcoxon rank-sum test or a Kruskal-Wallis analysis. For categorical variables, univariate analysis with logistic regression was performed.RESULTS: The database contains 222 patients, of which 85 subjects were managed with HFOV. Of this HFOV cohort, the overall pediatric ICU survival was 23.5% (n = 20). HFOV survivors were transitioned to HFOV at a lower oxygenation index than nonsurvivors (25.6, interquartile range 21.1–36.8, vs 37.2, interquartile range 26.5–52.2, P = .046). Survivors were transitioned to HFOV earlier in the course of mechanical ventilation, (day 0 vs day 2, P = .002). No subject survived who was transitioned to HFOV after 1 week of invasive mechanical ventilation. We compared subjects with severe pediatric ARDS treated only with conventional mechanical ventilation versus early HFOV (within 2 d of invasive mechanical ventilation) versus late HFOV. There was a trend toward difference in survival (conventional mechanical ventilation 24%, early HFOV 30%, and late HFOV 9%, P = .08).CONCLUSIONS: In this large database of pediatric allogeneic hematopoietic cell transplant subjects who had acute respiratory failure requiring invasive mechanical ventilation for critical illness with severe pediatric ARDS, early use of HFOV was associated with improved survival compared to late implementation of HFOV, and the subjects had outcomes similar to those treated only with conventional mechanical ventilation.