TY - JOUR T1 - Tiotropium for Treatment of Stable COPD: A Meta-analysis of Clinically Relevant Outcomes JF - Respiratory Care SP - 477 LP - 487 DO - 10.4187/respcare.00852 VL - 56 IS - 4 AU - Abebaw Mengistu Yohannes AU - Thomas George Willgoss AU - Jørgen Vestbo Y1 - 2011/04/01 UR - http://rc.rcjournal.com/content/56/4/477.abstract N2 - OBJECTIVE: To systematically review recent evidence on the effectiveness of tiotropium versus placebo, ipratropium, and long-acting β2 agonists on outcomes relevant to patients with stable COPD, including health-related quality of life, dyspnea, exacerbations and hospitalizations. METHODS: Our inclusion criteria for trials were: ≥ 12 weeks; compared tiotropium to placebo, ipratropium, or long-acting β agonists; patients ≥ 40 y old and with stable COPD. Sixteen trials (16,301 patients) met the inclusion criteria. RESULTS: Tiotropium improved health-related quality of life (measured with St George's Respiratory Questionnaire) compared to placebo (odds ratio [OR] 1.61, 95% CI 1.38–1.88, P < .001) and ipratropium (OR 2.03, 95% CI 1.34–3.07, P = .001). Tiotropium also improved dyspnea (measured with the Transitional Dyspnea Index) compared to placebo (OR 1.96, 95% CI 1.58–2.44, P < .001) and ipratropium (OR 2.10, 95% CI 1.28–3.44, P = .003). Tiotropium decreased the likelihood of an exacerbation (OR 0.83, 95% CI 0.72–0.94, P = .004) and related hospitalizations (OR 0.89, 95% CI 0.80–0.98, P = .02) but not serious adverse events (OR 1.06, 95% CI 0.97–1.17, P = .19), compared to placebo. The cumulative incidence of dry mouth was 7.4% with tiotropium, compared to 3.9% with ipratropium, 1.6% with salmeterol, and 2.0% with placebo. CONCLUSIONS: In stable COPD, tiotropium showed superior efficacy in improving quality of life and dyspnea, compared to placebo and ipratropium. However, tiotropium's differences with salmeterol were less clear. ER -