PT  - JOURNAL ARTICLE
AU  - Murri, Mora
AU  - García-Delgado, Regina
AU  - Alcázar-Ramírez, José
AU  - Fernández-Ramos, Ana
AU  - Alcaide, Juan
AU  - Cardona, Fernando
AU  - Tinahones, Francisco J
TI  - Effect of CPAP on Oxidative Stress and Circulating Progenitor Cell Levels in Sleep Patients With Apnea-Hypopnea Syndrome
AID  - 10.4187/respcare.01081
DP  - 2011 Nov 01
TA  - Respiratory Care
PG  - 1830--1836
VI  - 56
IP  - 11
4099  - http://rc.rcjournal.com/content/56/11/1830.short
4100  - http://rc.rcjournal.com/content/56/11/1830.full
AB  - BACKGROUND: The sleep apnea-hypopnea syndrome is associated with elevated oxidative stress, which is associated with reduced levels and functional impairment of progenitor cells. OBJECTIVE: To evaluate whether one month of CPAP treatment affects circulating-progenitor-cell levels and oxidative stress in patients with sleep apnea-hypopnea syndrome. METHODS: We enrolled 13 patients with sleep apnea-hypopnea syndrome who required nasal CPAP. We evaluated white-blood-cell oxidative stress and CD45−, CD34+, KDR+, and CD133+ cell levels via flow-cytometry, before and one month after CPAP treatment. RESULTS: Superoxide anion and hydrogen peroxide were reduced, and markers of protection against oxidative stress were increased after CPAP. Progenitor-cell levels increased significantly after CPAP. There was a significant negative correlation between CD45−, CD34+, KDR+, and CD133+ cell levels and the severity of sleep apnea-hypopnea syndrome and superoxide anion. CONCLUSIONS: CD45−, CD34+, KDR+, and CD133+ cell levels rose significantly and reached values close to those in the control group after one month of CPAP. This change was accompanied by a significant decrease in oxidative stress, and no change in anthropometric or metabolic variables, including insulin resistance, weight, blood pressure, or lipid levels; consequently, the increase in progenitor-cell levels might be attributable to reduced oxidative stress.