RT Journal Article
SR Electronic
T1 Surfactant Replacement Therapy in the Neonate: Beyond Respiratory Distress Syndrome
JF Respiratory Care
FD American Association for Respiratory Care
SP 1203
OP 1208
VO 54
IS 9
A1 Donn, Steven M
A1 Dalton, Jennifer
YR 2009
UL http://rc.rcjournal.com/content/54/9/1203.abstract
AB Surfactant-replacement therapy is a life-saving treatment for preterm infants with respiratory distress syndrome, a disorder characterized by surfactant deficiency. Repletion with exogenous surfactant decreases mortality and thoracic air leaks and is a standard practice in the developed world. In addition to respiratory distress syndrome, other neonatal respiratory disorders are characterized by surfactant deficiency, which may result from decreased synthesis or inactivation. Two of these disorders, meconium aspiration syndrome and bronchopulmonary dysplasia, might also be amenable to surfactant-replacement therapy. This paper discusses the use of surfactant-replacement therapy beyond respiratory distress syndrome and examines the evidence to date.