RT Journal Article SR Electronic T1 Upper Airway Assessment and Responses During Mechanically Assisted Cough JF Respiratory Care FD American Association for Respiratory Care SP 1196 OP 1213 DO 10.4187/respcare.08960 VO 66 IS 7 A1 Tiina M Andersen A1 Brit Hov A1 Thomas Halvorsen A1 Ola Drange Røksund A1 Maria Vollsæter YR 2021 UL http://rc.rcjournal.com/content/66/7/1196.abstract AB When the ability to cough is impaired, secretion clearance may be assisted and augmented with mechanical insufflation-exsufflation (MI-E). In some individuals, the efficacy of MI-E may be hampered by counterproductive upper airway reactions, where the airways close in response to positive pressures. To fully utilize the therapeutic potential inherent in the MI-E technology, we need a better understanding of the pathophysiology behind these untoward reactions. There is increasing interest in monitoring and measuring upper airway responses to MI-E and how such information can be used to optimize MI-E settings. The purpose of this narrative review is to increase the theoretical understanding of the larynx as a respiratory organ, summarize the current literature in the area, and provide insight into how this knowledge can affect current clinical practice.