TY - JOUR T1 - Prediction of Extubation Failure in COVID-19 JF - Respiratory Care SP - 1323 LP - 1329 DO - 10.4187/respcare.08564 VL - 66 IS - 8 AU - Pedro H de Andrade Filho AU - Eduardo S de Assis Brasil AU - Ladyer G Costa AU - Daniel Escóssia M Sousa AU - Talison S Pereira AU - João Manoel Silva, Jr Y1 - 2021/08/01 UR - http://rc.rcjournal.com/content/66/8/1323.abstract N2 - BACKGROUND: may be a reliable noninvasive alternative to the index. Furthermore, the ROX index (ie, the ratio of to breathing frequency) has been validated to predict high-flow nasal cannula failure in subjects under spontaneous breathing. However, these indices have not been tested in subjects with COVID-19 receiving invasive mechanical ventilation. This study aims to verify the correlation between both the ROX index and with and the ratio of to breathing frequency, and to determine the accuracy of the indices that use for the prediction of extubation failure in subjects with COVID-19.METHODS: A prospective cohort study was conducted from May 15, 2020, to June 15, 2020, with subjects with COVID-19 on invasive mechanical ventilation. Indices using in the formula were compared to those using . Additionally, the performance of the indices in predicting extubation failure was evaluated.RESULTS: This study included 69 subjects age 64.8 ± 14.6 y. There were no differences between the median values of the indices, including between the ROX index and to breathing frequency (P = .40) or between and (P = .83). When comparing the ROX index with the index to breathing frequency, they were found to be strongly correlated (R2 = 0.75 [95% CI 0.6763–0.8152], P < .001). The comparison of with revealed R2 = 0.70 (95% CI 0.563–0.749, P < .001). The area under the receiver operating characteristic curve for the ROX index to determine extubation failure was 0.74 (P = .01), whereas for it was 0.78 (P < .001).CONCLUSIONS: The indices presented a good correlation in subjects with COVID-19 on invasive mechanical ventilation, and both the ROX index and can discriminate extubation failure in this population. ER -