PT - JOURNAL ARTICLE AU - Piraino, Thomas AU - Madden, Maria AU - Roberts, Karsten J AU - Lamberti, James AU - Ginier, Emily AU - Strickland, Shawna L TI - AARC Clinical Practice Guideline: Management of Adult Patients With Oxygen in the Acute Care Setting AID - 10.4187/respcare.09294 DP - 2022 Jan 01 TA - Respiratory Care PG - 115--128 VI - 67 IP - 1 4099 - http://rc.rcjournal.com/content/67/1/115.short 4100 - http://rc.rcjournal.com/content/67/1/115.full AB - Providing supplemental oxygen to hospitalized adults is a frequent practice and can be administered via a variety of devices. Oxygen therapy has evolved over the years, and clinicians should follow evidence-based practices to provide maximum benefit and avoid harm. This systematic review and subsequent clinical practice guidelines were developed to answer questions about oxygenation targets, monitoring, early initiation of high-flow oxygen (HFO), benefits of HFO compared to conventional oxygen therapy, and humidification of supplemental oxygen. Using a modification of the RAND/UCLA Appropriateness Method, 7 recommendations were developed to guide the delivery of supplemental oxygen to hospitalized adults: (1) aim for range of 94–98% for most hospitalized patients (88–92% for those with COPD), (2) the same range of 94–98% for critically ill patients, (3) promote early initiation of HFO, (4) consider HFO to avoid escalation to noninvasive ventilation, (5) consider HFO immediately postextubation to avoid re-intubation, (6) either HFO or conventional oxygen therapy may be used with patients who are immunocompromised, and (7) consider humidification for supplemental oxygen when flows > 4 L/min are used.