@article {Gros2026, author = {Antoine Gros and Laurent Holzapfel and Sophie Marqu{\'e} and Laurent Perard and Guy Demingeon and Bonavie Piralla and Sandrine Gaillard and Xavier Tchenio}, title = {Intra-individual Variation of the Cuff-Leak Test as a Predictor of Post-Extubation Stridor}, volume = {57}, number = {12}, pages = {2026--2031}, year = {2012}, doi = {10.4187/respcare.01527}, publisher = {Respiratory Care}, abstract = {BACKGROUND: This was an evaluation of intra-individual variation of the cuff-leak test (ΔCLT) immediately post-intubation and pre-extubation, as a predictor of post-extubation stridor. METHODS: Prospective, clinical investigation in the ICU of a non-university hospital. CLTs were performed immediately after intubation (T0) and before extubation (T1) to evaluate the differences in cuff leak (ΔCLT = CLT1 - CLT0). RESULTS: We included 104 mechanically ventilated subjects in the study over a 12-month period. The incidence of post-extubation stridor was 6.7\%. Stridor was more common in females of short stature. ΔCLT was considered as significant when CLT1 - CLT0 was negative. The sensitivity and the specificity of the test were 86\% and 48\%, respectively. When we tested the pre-extubation CLT alone with a threshold of 130 mL as a predictor of post-extubation stridor, the sensitivity and the specificity of the test were 86\% and 76\%, respectively. CONCLUSIONS: The intra-individual variation of CLT immediately post-intubation and pre-extubation does not improve the accuracy of a standard pre-extubation CLT to predict post-extubation stridor. Moreover, the standard pre-extubation CLT did not appear in our study to be an ideal test to detect post-extubation stridor. Larger studies should be performed before generalizing these preliminary results.}, issn = {0020-1324}, URL = {https://rc.rcjournal.com/content/57/12/2026}, eprint = {https://rc.rcjournal.com/content/57/12/2026.full.pdf}, journal = {Respiratory Care} }