RT Journal Article SR Electronic T1 Analysis of Risk Factors for Extubation Failure in Subjects Submitted to Non-Emergency Elective Intracranial Surgery JF Respiratory Care FD American Association for Respiratory Care SP 2059 OP 2066 DO 10.4187/respcare.01039 VO 57 IS 12 A1 Milena Carlos Vidotto A1 Luciana Carrupt Machado Sogame A1 Mariana Rodrigues Gazzotti A1 Mirto Nelson Prandini A1 José Roberto Jardim YR 2012 UL http://rc.rcjournal.com/content/57/12/2059.abstract AB BACKGROUND: Extubation failure is defined as the re-institution of respiratory support ranging from 24 to 72 hours following scheduled extubation and occurs in 2% to 25% of extubated patients. The aim of this study was to determine clinical and surgical risk factors that may predict extubation failure in patients submitted to non-emergency intracranial surgery. METHODS: This was a prospective observational cohort study. The study was carried out on 317 subjects submitted to non-emergency intracranial surgery for tumors, aneurysms, and arteriovenous malformation. Preoperative assessment was performed and subjects were followed up for the determination of extubation failure until either discharge from hospital or death. RESULTS: Twenty-six (8.2%) of the 317 subjects experienced extubation failure following surgery. The following variables were considered for the multivariate analysis: level of consciousness at the time of extubation, duration of mechanical ventilation prior to extubation, sex and the use of intraoperative mannitol. The multivariate analysis determined that the most important variable for extubation failure was the level of consciousness at the time of extubation (P = .001), followed by female sex, which also showed to be significant (P = .006). CONCLUSIONS: Lower level of consciousness (GCS 8T-10T) and female sex were considered risk factors for extubation failure in subjects submitted to elective intracranial surgery.