PT - JOURNAL ARTICLE AU - David M Mannino TI - The Changing Definition and Perception of COPD AID - 10.4187/respcare.10059 DP - 2022 Jun 01 TA - Respiratory Care PG - 750--755 VI - 67 IP - 6 4099 - http://rc.rcjournal.com/content/67/6/750.short 4100 - http://rc.rcjournal.com/content/67/6/750.full AB - COPD remains one of the leading causes of death worldwide. The impact of smoking and air pollution remain important causative factors. Traditional classification of COPD includes the overlap of emphysema, chronic bronchitis and asthma. More recently the COPDGene definition includes the terms possible, probable and definite COPD. These are supported by findings from exposures, symptoms, spirometry and radiologic imaging. This new approach can lead to earlier diagnosis and modification of risk factors, earlier therapeutic intervention and improved treatments of established disease.