@article {Tisminetzky1067, author = {Manuel Tisminetzky and Bruno L Ferreyro and Fernando Frutos-Vivar and Andr{\'e}s Esteban and Fernando R{\'\i}os and Arnaud W Thille and Konstantinos Raymondos and Lorenzo Del Sorbo and {\'O}scar Pe{\~n}uelas and Eddy Fan}, editor = {R{\'\i}os, Fernando and Conforti, Antonio and Chena, Ariel and Pellegrini, Carlos and Plotnikow, Gustavo and Lebus, Janina and Osatnik, Javier and Sagardia, Judith and Bettini, Lisandro and Mar{\'\i}a Ducrey, Marcela and Iezzi, Nicol{\'a}s and Bezzi, Marco and Edith Emmerich, M{\'o}nica and Zuljevic, Nicol{\'a}s and Edgardo G{\'o}mez, Pablo and Alejandro G{\'o}mez, Ra{\'u}l and Fern{\'a}ndez, Rub{\'e}n O. and Ilutovich, Santiago and Fredes, Sebasti{\'a}n and Mare, Sebasti{\'a}n and Bersten, Andrew and Matheson, Elisha and Rodgers, Helen and van Haren, Frank and Russell-Brown, Josie and Nourse, Mary and Jefferson, Katie and Mckew, Sarah and Wong, Helen and Schwartz, Kate and Coutts, Sandra and Hermans, Greet and Bourgeois, Marc and Denolf, Joke and Ceunen, Helga and Valle-Pinheiro, Bruno and Silva, Gustavo and Prata, Cristina and L{\'u}cia Gut, Ana and Oswaldo Abreu, Arthur and Bonaccorsi, Bruno and Teixeira, Cassiano and Magalh{\~a}es, Cintia and Andrade, Cristiane and Jos{\'e} Ibrahim Zeghzeghi, David and Ferreira, Fabio and Pedrosa, Edimar and Fonseca, Fernando and Luiz de Aguiar, Fl{\'a}vio and Costa, Frederico and Sanders-Pinheiro, H{\'e}lady and Oliveira Freire, Carina and Urbano, Hugo and Luiz Rocha, Jorge and Carlos Fernandez Versiani, Jos{\'e} and Carvalho, Juliana and Carmen Mendes, Maria and Aparecida Braga, Maria and Moura, Maycon and Rodrigues J{\'u}nior, Milton and Elias de Oliveira, Neymar and Santos, Nivaldo and C{\'e}sar Jorge, Amaury and Almeida Delfino, P{\'e}ricles and Lara, Rovilson and Altair Amaral de P{\'a}dua, Rubens and Teixeira Sant{\textquoteright}Anna, Sergio and Olivier Ticom, Thatiane and de Oliveira, Wilson and del Sorbo, Lorenzo and Pettenuzzo, Tommaso and Fan, Eddy and D. Ferguson, Niall and Soto-Germani, Luis and Du, Bin and Chen, Yu and Dong, Chenming and Ding, Chengzhi and Nie, Cheng and Shao, Qiang and Zhang, Yan and Chen, Qian and Xu, Lei and Jiang, Wei and Ma, Yu and Shen, Feng and Sui, Feng and Miao, Jiahui and Li, Wenxiong and Ma, Wenliang and Jiang, Yijia and Zheng, Yue and Zhang, Qiuchen and Gao, Ying and Gao, Jingli and Gong, Xiaohui and Guo, Liqing and Qiu, Haibo and Han, Jinhai and Tian, Hongcheng and Zhao, Hongsheng and Hou, Ming and Long, Huaicong and Huang, Chulin and Ge, Huiqing and Zhang, Jian and Zhou, Jian and Yang, Xuefei and Wang, Yaoli and Li, Rui and Li, Ning and Yu, Li and Wu, Xiaoling and Pan, Liwei and Li, Deyong and Zhang, Lijuan and Wu, Meng and Guan, Lina and He, Liping and Huang, Liquan and Liu, Lei and Liu, Mili and Liu, Shuangqing and Liu, Jingfeng and Yuan, Zhide and Liu, Xiujuan and Zuo, Zhigang and Han, Pan and Pang, Jing and Li, Peijun and Pu, Xuehua and Ge, Qinggang and Wang, Qiuhui and Wang, Ruilan and Xie;, Yun and Zheng, Ruiqiang and Shen, Wenjuan and Baoan, Shenzhen and Su, Shengyuan and Shuai, Weizheng and Zhao, Shuangping and Su, Yingying and Fan, Linlin and Sun, Jiajun and Sun, Yun and Sun, Tongwen and Wang, Xiaozhi and Wang, Xue and Wan, Xianyao and Huang, Xiaobo and Zhang, Xiaohong and Xu, Xiaomao and Chen, Xiaomei and Xu, Haifeng and Zhou, Yongfang and Yuan, Yuan and Yu, Yuetian and Li, Yujie and Zhang, Dehou and Zhang, Kun and Zhang, Minwei and Du, Qiguang and Ye, Zhenglong and Rao, Zhenyi and Peng, Zhiyong and Zhou, Fachun and Zhou, Jianxin and Zhu, Yibing and Jun, Zhang and Min Qiang, Huang and Lili, An and Gonz{\'a}lez, Marco and Paola Franco, Adriana and Viviana Lozano, Gineth and Rojas, Daniel and Chingate, Carolina and Vidales, Leidys and Mu{\~n}oz, Mauricio and Romero, Diana and Telag, Bibiana and Burbano, Taylor and Mar{\'\i}a Luna Diana, Ang{\'e}lica and Carrillo, Ang{\'e}lica and Moncayo, Harvey and Pablo Ospina, Juan and Alejandro Gil, Bladimir and Hurtado, Carlos and Enciso, Cesar and Mauro Arias, Carlos and Yepes, David and Andr{\'e}s Ben{\'\i}tez, Federico and Molina, Francisco and G{\'o}mez, Mario and Libreros, Giovanni and Cepeda, Gloria and Ortiz, Guillermo and G{\'o}mez Duque, Mario and {\'A}lvarez, Felipe and Fidel Jaraba, Jos{\'e} and Luis Echeverri, Juan and Mar{\'\i}a Saucedo, Lina and Elena Ochoa, Mar{\'\i}a and Granados, Marcela and P{\'e}rez Guti{\'e}rrez, Norton and Thomen, Rafael and Espinosa, Rigoberto and Antonio Medina, Ronald and Eugenia {\'A}ngel Mej{\'\i}a, Victoria and Roc{\'\i} C{\'a}rdenas, Yenny and Ferrer, Leopoldo and Espinosa, Rigoberto and Jibaja, Manuel and Garc{\'\i}a, Fernanda and Ram{\'\i}rez, Vanesa and Hurtado, Jorge and del Pozo, Gustavo and Salgado, Estuardo and Manuel Figueroa, Victor and Ochoa, Marcelo and Reinoso, Priscilla and Rivadeneira, Francisco and Acosta, Mario and Bello, Manuel and Thille, Arnaud W. and Anguel, Nadia and Beurton, Alexandra and B{\'e}duneau, Ga{\"e}tan and Girault, Christophe and Beuret, Pascal and Devillez, Simon and Boissier, Florence and Bretagnol, Anne and Mathonnet, Armelle and de Jong, Audrey and Jaber, Samir and Dellamonica, Jean and Gratia, Elisabeth and Terzi, Nicolas and Gu{\'e}rin, Claude and Perinel, Sophie and Gu{\'e}rot, Emmanuel and Monnier, Alexandra and Le Meur, Matthieu and Roux, Damien and L{\textquoteright}Her, Erwan and Nseir, Saad and Rouz{\'e}, Anahita and Soupison, Thierry and Raymondos, Konstantinos and Bickenbach, Johannes and Pezechk, Jessica and Mihailescu, Cezar and Moellhoff, Thomas and Schneider, Roland and Matties, Ronald and Haas, Hansj{\"o}rg and Seyboth, Stefan and Schoeffel, Volker and Reutershan, Jorg and Weber-Carstens, Stefan and Brederlau, Jorg and Kraemer, Michael and Putensen, Christian and Ahrens, Jorg and Terhorst, Kirsten and Buchmann, Alexander and Sander, Ralph and Albrecht, Bodo and Rabba, Matthias and Weilbach, Christian and Buettner, Jens and Reisbach, Linda and Ulbricht, Alin and Jung, Christian and Zhu, Ernan and Schmidt, Maren and Weiland, Dirk and Herbstreit, Frank and Peters, Jurgen and Ernst, J{\"u}rgen and Wiesenack, Christoph and Tomelden, June and Rauch, Stefan and Fischer, Matthias and Kenchen, Andrea and Iversen, Maja and Salameh, Yones and Seitz, Wolfgang and Wagner, Martin and Gnielinski, Mathias and Gottschalk, Andr{\'e} and Honig, Frauke and Fegbeutel, Christine and Knitsch, Wolfgang and Wilhelmi, Mathias and Ruschulte, Heiner and Panke, Sebastian and Schott, Martin and Tautz, Bernard and David, Matthias and Kobusch, Karin and Hensel, Hongting and Scharnofske, Jorg and Chorianopoulos, Emanuel and Preusch, Michael and Hoffmann, Marion and von Knobelsdorff, George and Wedel, Beate and Hohn, Andreas and Hinkelbein, Jochen and Plessow, Joanna and Rolfes, Caroline and Lindner, Joachim and Wrigge, Hermann and Ginz, Hans F. and Goerdes, Detlef and Frenkel, Christian and Tietz, Caren and Pohl, Walter and Siebers, Christian and Henkel, Jochen and Ney, Ludwig and Frey, Lorenz and Rabe, Chritian and Brettner, Frank and Rembold, Vanessa and Meyer, Joachim and Ziegler, Michael and Schulze, Karl and Bein, Thomas and Holten, Dirk and Schappacher, Markus and Allgaeuer, Sebastian and Phillip Zucker, Tom and Glaser, Martin and Schmola, Markus and Kredel, Marcus and Soukup, Jean and Matamis, Dimitrios and Flevari, Aikaterini and Christos, Christofis and Manoulakas, Efstratios and Mouloudi, Eleni and Massa, Eleni and Papaioannou, Maria and Polychronis, Tasioudis and Vasileiadou, Georgia and Synnefaki, Eleni and Luis Ranero, Jorge and Estuardo {\'A}vila, Luis and Armando Mu{\~n}oz, Jos{\'e} and Silvia Bonilla, Ana and M{\'e}ndez, Erick and Jos{\'e} Deyet, Juan and Abraham Reyes, Gary and Martin-Loeches, Ignacio and Honan, David and Zilahi, Gabor and Fitzpatrick, Gerry and Maurizio Maggiore, Salvatore and Roasio, Agostino and Sacco, Alice and Bottazzi, Andrea and Neville Cracchiolo, Andrea and Cotoia, Antonella and Micalizzi, Camilla and Longhini, Federico and Tardini, Francesca and Curto, Francesco and Maugeri, Jessica and Maria Montini, Luca and Mirabella, Lucia and Pozzi, Marco and Elena, Maria and Bottiroli, Maurizio and Rocco, Monica and Logrieco, Nicola and Murino, Patrizia and Grasso, Salvatore and Spadaro, Savino and Livigni, Sergio and Romagnoli, Stefano and Spina, Tullio and Amin, Pravin and Kumar Mani, Ashwin and Ray, Banambar and Devaprasad, Dedeepiya and Jayakumar, Devachandran and Dumra, Harjit and Natarajan, Karthiraj and Patil, Leena and Shah, Mehul and Ramakrishnan, Nagarajan and Ebenezer, R and Chawla, Rajesh and Sahu, Samir and Ramasubban, Suresh and Young Suh, Gee and Jang, Eumi and Bum Lee, Heung and Jiyoung, Hong and Koo Kang, Hyung and Eunsuk, Jeong and Young Hong, Ji and Hwa Lee, Jin and Jeon, Jinhee and Hee Park, Ju and Kyung Chan, Kim and Lee, Sang-Min and Young Park, So and Park, Sunghoon and Lee, Won-Yeon and Choi, Wonil and Joo Lee, Yeon and Su Sim, Yun and Man Lim, Chae and del Carmen Marin, Maria and Ortega P{\'e}rez, Abad Q and Ch{\'a}vez, Alfonso and Augusto P{\'e}rez-Calatayud, {\'A}ngel and Garc{\'\i}a-Luna, Alfonso and Rugerio, Andrea and Arellano, Alfredo and Velasco, Arturo and Jos{\'e} Longino, Asunci{\'o}n and Tamariz, Antonio and Muguerza, Christus and Ivette Reynoso, Claudia and D{\textquoteright}ector-Lira, Dulce and Guti{\'e}rrez-Zarate, Dami{\'a}n and P{\'e}rez, Dulce and Daniel Anica Malag{\'o}n, Eduardo and Monares, Enrique and Deloya, Ernesto and Manzo, Ervin and De Jes{\'u}s Montelongo, Felipe and Javier Flores, Francisco and Ram{\'\i}rez, Mavy and Camarena, Gilberto and Felipe V{\'a}zquez, Gilberto and V{\'a}zquez, H{\'e}ctor and Morales, Gustavo and Edgar Zamora, Sergio and Maga{\~n}a, Georgina and Isidro S{\'a}nchez-Gonz{\'a}lez, Jes{\'u}s and Rosendo S{\'a}nchez-Medina, Jorge and Zaragoza, Jos{\'e} J and Antonio Buensuseso, Juan and Carlos D{\'a}vila, Juan and Mijangos-M{\'e}ndez, Julio C and Mart{\'\i}nez-Medina, Manuel and Chac{\'o}n, Mar{\'\i}a and Ver{\'o}nica Calyeca, Mar{\'\i}a and Jorge Mart{\'\i}nez-Soria, Jos{\'e} and M{\'e}ndez, Raquel and de Jes{\'u}s Garc{\'\i}a-Graullera, Roberto and Rosas, Roberto and Sanjuana, Saira and Reyes, Sergio and {\~N}amendys-Silva, Silvio A and Estrada Guti{\'e}rrez, Alfonso and Maycotte, Zalatiel and Castellanos, Villegas and Lizette, Lilian and S{\'a}nchez-Hurtado, Luis Alejandro and Larios, Carlos and Ali Zeggwagh, Amine and Akkaoui, Elmostafa and Amor, Mourad and Belkhi, Hicham and Haimeur, Charki and Ezzouine, Hanane and Elkhayari, Mina and Dendane, Tarek and Kuiper, Michael and Koopmans, Matty and Parke, Rachael and France, Dawn and Goodson, Jennifer and Sol Cruz, Raulle and Arguello, Becket and Rafael Gutierrez-Mu{\~n}oz, Fernando and Giuliana Meza, Monica and Manuel Cruz, Jos{\'e} and Wilber Portugal, Jos{\'e} and Contardo, Manuel and Laca, Manuel and Castillo, Luis and Bisso, Aland and Quispe, Rocio and Oyanguren, Indira and Dias, Sofia and Honrado, Teresa and Rodr{\'\i}guez, Gloria and Gonz{\'a}lez-Barreto, Wilma and Col{\'o}n-Barreto, Br{\'\i}gida and Rosado-Paso, Christian and Delgado, Yara and Pe{\~n}uelas, {\'O}scar and Blandino, Aaron and de Pablo, Ra{\'u}l and Gajate, Luis and Belenguer, Alberto and Levy, Alberto and Moneo, Alejandro and Busto, Beatriz and Ortu{\~n}o, Francisco and Ortega, Alfonso and Veganzones, Javier and Cabanillas, Amparo and Cruz, Manuel and Mar{\'\i}a de Pablo, Ana and Zubillaga, Susana and Mart{\'\i}n-Pellicer, Ana and Villagr{\'a}, Ana and Algaba, {\'A}ngela and Gonz{\'a}lez-Gonz{\'a}lez, Elena and Alonso-Ovies, {\'A}ngela and V{\'a}zquez-S{\'a}nchez, Antonia and Dot, Irene and Ram{\'o}n Masclans, Joan and Garc{\'\i}a-Jim{\'e}nez, Antonio and Vi{\~n}uales, Antonio and Mar{\'\i}a, Anxela and Abad, Beatriz and Cereijo, Enrique and de Haro, Candelaria and Martin-L{\'o}pez, Caridad and Subira, Carles and Vicent, Carlos and Garc{\'\i}a-Martin, Carolina and Huidobro, Samantha and Forteza, Catalina and Rialp, Gemma and Laborda, C{\'e}sar and Riera, Jordi and Sacanell, Judit and Roca, Oriol and Mart{\'\i}nez-Fidalgo, Concepci{\'o}n and Arizo, David and Granado, David and Dom{\'\i}nguez-Garc{\'\i}a, Pedro J and Hermosa, Cecilia and Morales, Eduardo and Palencia, Eduardo and Abril, Elena and Padilla, Rebeca and Hidalgo, Fernando and Estrella, Alfonso and Luis Palaz{\'o}n, Eugenio and Minaya, Federico and Mart{\'\i}n-Gonz{\'a}lez, F{\'e}lix and Callejo-Torre, Fernando and Iglesias, Fernando and Valledor, Manuel and Mart{\'\i}n-Cuadrado, Marta and Roche-Campo, Ferr{\'a}n and Mar{\'\i}a Raurich, Joan and Ferreruela, Mireia and Teresa Mill{\'a}n, Mar{\'\i}a and Lucena, Francisco and Sancho, Helena and Escudero, Germ{\'a}n and Hern{\'a}ndez, Gonzalo and Guerrero-L{\'o}pez, Francisco and Hern{\'a}ndez-Garc{\'e}s, H{\'e}ctor and Aguirre-Bermeo, Hern{\'a}n and Torrens, Mar{\'\i}a and Rodr{\'\i}guez, Nuria and S{\'a}ez, Ignacio and Temprano, Susana and Garc{\'\i}a Gigorro, Renata and Prieto, Isidro and Vallverd{\'u}, Immaculada and Astola, Iv{\'a}n and Yano, Raquel and Blanco, Jes{\'u}s and Mar{\'\i}a Quiroga, Jos{\'e} and Antonio Fern{\'a}ndez-Ratero, Jos{\'e} and Mart{\'\i}nez-Barrios, Miguel and Luis Flordelis, Jos{\'e} and {\'A}ngel Blasco-Navalpotro, Miguel and D{\'\i}az-Abad, Ricardo and Mar{\'\i}a Mont{\'o}n, Jos{\'e} and Carmen Espinoza, Mar{\'\i}a and Elena Plumed, Mar{\'\i}a and Jos{\'e} Tolon, Mar{\'\i}a and Teresa Jurado, Mar{\'\i}a and del Carmen Fern{\'a}ndez-Gonz{\'a}lez, Mar{\'\i}a and del Rosario Truchero, Mar{\'\i}a and Elena P{\'e}rez-Losada, Mar{\'\i}a and Isabel Rubio, Mar{\'\i}a and L{\'o}pez-S{\'a}nchez, Marta and Isabel Ruiz-Garc{\'\i}a, Mar{\'\i}a and Consuelo Pintado, Mar{\'\i}a and Trascasa Mu{\~n}oz, Mar{\'\i}a and Ugalde, Marta and Serna, Pablo and Mart{\'\i}nez-Gonz{\'a}lez, Oscar and Le{\'o}n, Miguel and Ferrer, Miquel and Magret, M{\`o}nica and Mu{\~n}oz-L{\'o}pez, Alfonso and Tomas, Roser and Fern{\'a}ndez, Salvador and Franco, Nieves and Salgado, Patricia and Su{\'a}rez-de la Rica, Alejandro and S{\'a}nchez-Iniesta, Rafael and Montiel, Raquel and Montoiro, Raquel and Velilla, Carmen and Ismael Gonz{\'a}lez-Luengo, Ra{\'u}l and Galeiras, Rita and Almaraz, Roc{\'\i}o and Mar{\'\i}a {\'A}lvaro, Rosa and Tomas, Roser and Caba{\~n}es, Sara and Pedro Tirapu, Juan and Garc{\'\i}a-Montesinos, Manuel and Garc{\'\i}a-Herrera, Adriana and Esther de la Cruz, Laura and Anzueto, Antonio and Duarte, Alexander G and Nishi, Shawn and Goodlett, Shawn and Skinkis, Paula and Hirst, Roxana and Pope, Caryn O and Schmidt, Gregory A and Amendola, Julie A and Patel, Mayur B and Hosay, Morgan A and Stewart, James W and Meena, Nikhil and Duggal, Abhijit and Mireles-Cabodevila, Eduardo and Kaur, Gurpreet and Hastings, Andrei and Ferrari, Michelle and Rivera-Arzon, Ginger and Aruz, Felicita and Otero-Dominguez, Yomayra and Rodriguez-Cintron, William and Habib, Sheila and Estrada, Rodolfo and Assal, Hebatallah and Sutherasan, Yuda and Kongpolprom, Napplika and Rittayamai Phunsup, Nuttapol and Thomrongpairoj, Preecha and Theerawit, Pongdhep and Abroug, Fekri and Jamoussi, Amira and Mohamed Ali, Cherif and Mustapha, Ferjani and Guizani, Tayeb and Nejla, Tilouch and Hammouda Abed, Zeineb and Jerbi, Zouheir and Cakar, Nahit and Erdivanl, Ba{\c s}ar and Dilek, Ahmet and Esmaoglu, Aliye and Ozg{\"u}ltekin, Asu and Sen, Betul and Gucyetmez, Bulent and Erdogan, Cem and Tok, Demet and Surav, Dilek and Ozturk, Erdogan and Daskaya, Hayrettin and Senturk, Evren and Sabri Ozden, Eyyup and Esen, Figen and Karab{\i}y{\i}k, Lale and Turan, Guldem and Ayo{\u g}lu, Hilal and Sungurtekin, Hulya and Ulusoy, Hulya and Ozkan Akinci, Ibrahim and Sel{\c c}uk, Mehtap and Baykara, Nur and Ergin Ozcan, Perihan and Coskun, Ramazan and Tavuk{\c c}u {\"O}zkan, Sedef and Dasc{\i}, Selcuk and Turan, Sema and Konar, Serhat and Ljama, Taner and Acar, Umut and Orak, Yavuz and Ela, Yuksel and Nin, Nicol{\'a}s and Deicas, Alberto and Serra, Carolina and Nu{\~n}ez, Edgardo and Pereira, Patricia and Illardi, Lucia and Cabrera, Julio and Burghi, Gast{\'o}n and Aramendi, Ignacio and Alfonso, Miguel and Bango, Ariel and Briva, Arturo and Santos, Cristina and Montoya, Elizabeth and Giordano, Alvaro and Pais, Richard and Nin, Nicolas and Hurtado, Javier and L{\'o}pez, Luc{\'\i}a and Mendez, Diego and Nu{\~n}ez, Carlos and Pittini, Gustavo}, title = {Decline in Ventilatory Ratio as a Predictor of Mortality in Adults With ARDS Receiving Prone Positioning}, volume = {67}, number = {9}, pages = {1067--1074}, year = {2022}, doi = {10.4187/respcare.09783}, publisher = {Respiratory Care}, abstract = {BACKGROUND: Prone positioning reduces mortality in patients with moderate/severe ARDS. It remains unclear which physiological parameters could guide clinicians to assess which patients are likely to benefit from prone position. This study aimed to determine the association between relative changes in physiological parameters at 24 h of prone positioning and ICU mortality in adult subjects with ARDS.METHODS: We conducted a cohort study using the VENTILA database, including adults with ARDS receiving prone positioning. We used multivariable logistic regression to assess the association between relative changes in physiological parameters (PaO2/FIO2, dynamic driving pressure, PaCO2, and ventilatory ratio defined as [minute ventilation [mL/min] {\texttimes} PaCO2 [mm Hg]]/[predicted body weight {\texttimes} 100 [mL/min] {\texttimes} 37.5 [mm Hg] with ICU mortality) (primary outcome). We report adjusted odds ratios with 95\% CI as measures of association.RESULTS: We included 156 subjects of which 82 (53\%) died in the ICU. A relative decline in the ventilatory ratio at 24 h was associated with lower ICU mortality (odds ratio 0.80 [95\% CI 0.66{\textendash}0.97], every 10\% decrease). Relative changes in PaO2/FIO2 (odds ratio 0.89 [95\% CI 0.77{\textendash}1.03], every 25\% increase), PaCO2 (odds ratio 0.97 [95\% CI 0.82{\textendash}1.16], every 10\% decrease), and dynamic driving pressure (odds ratio 0.98 [95\% CI 0.89{\textendash}1.07], every 10\% decrease) were not associated with ICU mortality.CONCLUSIONS: In subjects with ARDS receiving prone positioning, a relative decline in the ventilatory ratio at 24 h was associated with lower ICU mortality.}, issn = {0020-1324}, URL = {https://rc.rcjournal.com/content/67/9/1067}, eprint = {https://rc.rcjournal.com/content/67/9/1067.full.pdf}, journal = {Respiratory Care} }