RT Journal Article SR Electronic T1 Daily oxygenation support for patients hospitalized with SARS-CoV-2 in an integrated health system JF Respiratory Care FD American Association for Respiratory Care SP respcare.10401 DO 10.4187/respcare.10401 A1 Valerie Danesh A1 Heath White A1 Kristen M Tecson A1 R Jay Widmer A1 Elisa L Priest A1 Ariel Modrykamien A1 Gerald O Ogola A1 I-Chia Liao A1 Jacallene Bomar A1 Alfredo Vazquez A1 Edgar J Jimenez A1 Alejandro C Arroliga YR 2022 UL http://rc.rcjournal.com/content/early/2022/10/11/respcare.10401.abstract AB Background: Many studies of novel coronavirus 2019 (COVID-19) are constructed to report hospitalization outcomes, with few large multi-center population-based reports on the time course of intra-hospitalization characteristics, including daily oxygenation support requirements. Comprehensive epidemiologic profiles of oxygenation methods used by day and by week during hospitalization across all severities are important to illustrate the clinical and economic burden of COVID-19 hospitalizations.Methods: This is a retrospective, multicenter observational cohort study of 15,361 consecutive hospitalizations of patients with COVID-19 at 25 adult acute care hospitals in Texas participating in the Society of Critical Care Medicine Discovery Viral Respiratory Illness Universal Study (VIRUS) COVID-19 registryResults: At initial hospitalization, the majority required nasal cannula (44.0%) with increasing proportion of invasive mechanical ventilation in the first week and particularly the weeks to follow. After four weeks of acute illness, 69.9% of adults hospitalized with COVID-19 required intermediate (e.g., high-flow nasal cannula, non-invasive ventilation) or advanced respiratory support (e.g., invasive mechanical ventilation), with similar proportions extending to hospitalizations lasting 6 weeks or longer.Conclusions: Data representation of intra-hospital processes of care drawn from hospitals with varied size, teaching and trauma designations is important to presenting a balanced perspective of care delivery mechanisms employed, such as daily oxygen method utilization.