PT  - JOURNAL ARTICLE
AU  - Baedorf Kassis, Elias N
AU  - Hu, Stephanie
AU  - Lu, MingYu
AU  - Johnson, Alistair E W
AU  - Bose, Somnath
AU  - Schaefer, Maximilian S
AU  - Talmor, Daniel S
AU  - Lehman, Li-Wei H
AU  - Shahn, Zach S
TI  - Titration of Ventilator Settings to Target Driving Pressure and Mechanical Power
AID  - 10.4187/respcare.10258
DP  - 2022 Nov 08
TA  - Respiratory Care
PG  - respcare.10258
4099  - http://rc.rcjournal.com/content/early/2022/11/08/respcare.10258.short
4100  - http://rc.rcjournal.com/content/early/2022/11/08/respcare.10258.full
AB  - BACKGROUND: Driving pressure (ΔP) and mechanical power (MP) may be important mediators of lung injury in ARDS; however, there is little evidence for strategies directed at lowering these parameters. We applied predictive modeling to estimate the effects of modifying ventilator parameters on ΔP and MP.METHODS: Two thousand six hundred twenty-two subjects with ARDS (Berlin criteria) from the Medical Information Mart for Intensive Care IV version 1.0 database admitted to the ICU at Beth Israel Deaconess Medical Center between 2008–2019 were included. Flexible confounding-adjusted regression models for time-varying data were fit to estimate the effects of adjusting PEEP and tidal volume (VT) on ΔP and adjusting VT and breathing frequency (f) on MP.RESULTS: Reduction in VT reduced ΔP and MP, with more pronounced effect on MP with lower compliance. Strategies reducing f consistently increased MP (when VT was adjusted to maintain consistent minute ventilation). Adjustment of PEEP yielded a U-shaped effect on ΔP.CONCLUSIONS: This novel conditional modeling confirmed expected response patterns for ΔP, with the response to adjustments depending on subjects’ lung mechanics. Furthermore, a VT-driven approach should be favored over an f-driven approach when aiming to reduce MP.