TY - JOUR T1 - Experimental Model of Atelectasis in Newborn Piglets JF - Respiratory Care SP - 121 LP - 126 DO - 10.4187/respcare.02352 VL - 59 IS - 1 AU - Talitha Comaru AU - Humberto Holmer Fiori AU - Renato Machado Fiori AU - Priscila Padoim AU - Jaqueline Basso Stivanin AU - Vinicius Duval da Silva Y1 - 2014/01/01 UR - http://rc.rcjournal.com/content/59/1/121.abstract N2 - BACKGROUND: There are few studies using animal models in chest physical therapy. However, there are no models to assess these effects in newborns. This study aimed to develop a model of obstructive atelectasis induced by artificial mucus injection in the lungs of newborn piglets, for the study of neonatal physiotherapy. METHODS: Thirteen newborn piglets received artificial mucus injection via the endotracheal tube. X-rays and blood gas analysis confirmed the atelectasis. RESULTS: The model showed consistent results between oxygenation parameters and radiological findings. Ten (76.9%) of the 13 piglets responded to the intervention. This did not significantly differ from the expected percentage of 50% by the binomial test (95% CI 46.2–95%, P = .09). CONCLUSIONS: Our model of atelectasis in newborn piglets is both feasible and appropriate to evaluate the impact of physical therapies on atelectasis in newborns. ER -