RT Journal Article
SR Electronic
T1 Home Oxygen After Hospitalization for COVID-19: Results From the Multi-Center OXFORD Study
JF Respiratory Care
FD American Association for Respiratory Care
SP 281
OP 289
DO 10.4187/respcare.11436
VO 69
IS 3
A1 Freedman, Michael B
A1 Kim, Yoo Jin
A1 Kaur, Ramandeep
A1 Jain, Bijal V
A1 Adegunsoye, Ayodeji O
A1 Chung, Yu-Che
A1 DeLisa, Julie A
A1 Gardner, Jessica M
A1 Gordon, Howard S
A1 Greenberg, Jared A
A1 Kaul, Malvika
A1 Khouzam, Nader
A1 Labedz, Stephanie L
A1 Mokhlesi, Babak
A1 Rintz, Jacob
A1 Rubinstein, Israel
A1 Taylor, Analisa
A1 Vines, David L
A1 Ziauddin, Lubna
A1 Gerald, Lynn B
A1 Krishnan, Jerry A
YR 2024
UL http://rc.rcjournal.com/content/69/3/281.abstract
AB BACKGROUND: In the first months of the pandemic, prior to the introduction of proven-effective treatments, 15–37% of patients hospitalized with COVID-19 were discharged on home oxygen. After proven-effective treatments for acute COVID-19 were established by evidence-based guidelines, little remains known about home oxygen requirements following hospitalization for COVID-19.METHODS: This was a retrospective, multi-center cohort study of subjects hospitalized for COVID-19 between October 2020–September 2021 at 3 academic health centers. Information was abstracted from electronic health records at the index hospitalization and for 60 d after discharge. The World Health Organization COVID-19 Clinical Progression Scale score was used to identify patients with severe COVID-19.RESULTS: Of 517 subjects (mean age 58 y, 47% female, 42% Black, 36% Hispanic, 22% with severe COVID-19), 81% were treated with systemic corticosteroids, 61% with remdesivir, and 2.5% with tocilizumab. About one quarter of subjects were discharged on home oxygen (26% [95% CI 22–29]). Older age (adjusted odds ratio [aOR] 1.02 per 5 y [95% CI 1.02–1.02]), higher body mass index (aOR 1.02 per kg/m2 [1.00–1.04]), diabetes (yes vs no, aOR 1.73 [1.46–2.02]), severe COVID-19 (vs moderate, aOR 3.19 [2.19–4.64]), and treatment with systemic corticosteroids (yes vs no, aOR 30.63 [4.51–208.17]) were associated with an increased odds of discharge on home oxygen. Comorbid hypertension (yes vs no, aOR 0.71 [0.66–0.77) was associated with a decreased odds of home oxygen. Within 60 d of hospital discharge, 50% had documentation of pulse oximetry; in this group, home oxygen was discontinued in 46%.CONCLUSIONS: About one in 4 subjects were prescribed home oxygen after hospitalization for COVID-19, even after guidelines established proven-effective treatments for acute illness. Evidence-based strategies to reduce the requirement for home oxygen in patients hospitalized for COVID-19 are needed.