RT Journal Article
SR Electronic
T1 Arterial Stiffness Measured Via Carotid Femoral Pulse Wave Velocity Is Associated With Disease Severity in COPD
JF Respiratory Care
FD American Association for Respiratory Care
SP 274
OP 280
DO 10.4187/respcare.02621
VO 59
IS 2
A1 Halit Cinarka
A1 Servet Kayhan
A1 Aziz Gumus
A1 Murtaza Emre Durakoglugil
A1 Turan Erdogan
A1 Ibrahim Ezberci
A1 Asiye Yavuz
A1 Sevket Ozkaya
A1 Unal Sahin
YR 2014
UL http://rc.rcjournal.com/content/59/2/274.abstract
AB BACKGROUND: Patients with COPD face an increased risk of cardiovascular disease and increased cardiac mortality. Carotid femoral pulse wave velocity (cf-PWV) is a validated measure of arterial stiffness, a well recognized predictor of adverse cardiovascular outcomes, and offers higher predictive value than classical cardiovascular risk factors. We investigated the association between COPD and arterial stiffness using cf-PWV as a noninvasive technique. METHODS: This clinical study was prospective, observational, and cross-sectional. Sixty-two subjects with stable COPD and 22 healthy controls underwent physical examination, chest x-rays, pulmonary function tests, arterial blood gas analysis, and 6-min walk test, and cf-PWV was measured via a validated tonometry system. RESULTS: The COPD subjects had greater arterial stiffness than the control subjects, and that difference was associated with lower FEV1, PaO2, and oxygen saturation during the 6-min walk test. We observed higher cf-PWV in the COPD subjects with severe COPD than in the subjects with mild to moderate COPD. Only FEV1 was an independent predictor of cf-PWV. CONCLUSIONS: Our results suggest that arterial stiffness is increased in subjects with more severe and advanced COPD than in those with mild to moderate COPD. Air flow limitation and hypoxemia may induce increased arterial stiffness in COPD patients.