@article {Vald{\'e}s399, author = {Luis Vald{\'e}s and Esther San Jos{\'e} and Luc{\'\i}a Ferreiro and Antonio Golpe and Francisco Gude and Jos{\'e} M {\'A}lvarez-Doba{\~n}o and Marco F Pereyra and Mar{\'\i}a E Toubes and Francisco J Gonz{\'a}lez-Barcala}, title = {Interleukin 27 Could Be Useful in the Diagnosis of Tuberculous Pleural Effusions}, volume = {59}, number = {3}, pages = {399--405}, year = {2014}, doi = {10.4187/respcare.02749}, publisher = {Respiratory Care}, abstract = {BACKGROUND: The diagnosis of tuberculous pleural effusion (TBPE) has some limitations. We studied the efficacy of interleukin-27 (IL-27) in the diagnosis of TBPE. METHODS: We measured IL-27, adenosine deaminase (ADA), ADA-2, interferon-gamma (IFNγ), and the ADA{\textperiodcentered}IL-27 and ADA-2{\textperiodcentered}IL-27 products in all the pleural effusion fluids. The diagnostic yield of IL-27 was evaluated with receiver operating characteristic curves. RESULTS: Of 431 pleural effusions, 70 were tuberculous, 146 were neoplastic, 58 were parapneumonic, 28 were empyemas, 88 were transudates, and 41 were other types. With a cutoff point of 0.55 ng/mL, IL-27 had a sensitivity of 91.4\% and a specificity of 85.1\%, which were significantly less than ADA, ADA-2, IFNγ, ADA{\textperiodcentered}IL-27, or ADA-2{\textperiodcentered}IL-27. The area under the receiver operating characteristic curve for IL-27 (0.963) was also significantly lower than that for the other markers, except for IFNγ. However, IL-27 improved the sensitivity of ADA and ADA-2 through ADA{\textperiodcentered}IL-27 and ADA-2{\textperiodcentered}IL-27 products (100\% for both). CONCLUSIONS: IL-27 is less efficient than ADA and ADA-2 in the diagnosis of TBPE. However, ADA{\textperiodcentered}IL-27 and ADA-2{\textperiodcentered}IL-27 improve the diagnostic sensitivity of ADA and ADA-2, and thus could be useful in situations of high clinical suspicion and low ADA level. A value above the cutoff point of the latter is practically diagnostic of TBPE.}, issn = {0020-1324}, URL = {https://rc.rcjournal.com/content/59/3/399}, eprint = {https://rc.rcjournal.com/content/59/3/399.full.pdf}, journal = {Respiratory Care} }