RT Journal Article
SR Electronic
T1 Use and Outcomes of Noninvasive Ventilation for Acute Respiratory Failure in Different Age Groups
JF Respiratory Care
FD American Association for Respiratory Care
SP 36
OP 43
DO 10.4187/respcare.03966
VO 61
IS 1
A1 Ozsancak Ugurlu, Aylin
A1 Sidhom, Samy S
A1 Khodabandeh, Ali
A1 Ieong, Michael
A1 Mohr, Chester
A1 Lin, Denis Y
A1 Buchwald, Irwin
A1 Bahhady, Imad
A1 Wengryn, John
A1 Maheshwari, Vinay
A1 Hill, Nicholas S
YR 2016
UL http://rc.rcjournal.com/content/61/1/36.abstract
AB BACKGROUND: The prevalence of chronic disease and do-not-intubate status increases with age. Thus, we aimed to determine characteristics and outcomes associated with noninvasive ventilation (NIV) use for acute respiratory failure (ARF) in different age groups.METHODS: A database comprising prospective data collected on site on all adult patients with ARF requiring ventilatory support from 8 acute care hospitals in Massachusetts was used.RESULTS: From a total of 1,225 ventilator starts, overall NIV utilization, success, and in-hospital mortality rates were 22, 54, and 18% in younger (18–44 y); 34, 65, and 13% in middle-aged (45–64 y); 49, 68, and 17% in elderly (65–79 y); and 47, 76, and 24% in aged (≥80 y) groups, respectively (P < .001, P = .08, and P = .11, respectively). NIV use for cardiogenic pulmonary edema and subjects with a do-not-intubate order increased significantly with advancing age (25, 57, 57, and 74% and 7, 12, 18, and 31%, respectively, in the 4 age groups [P < .001 and P = .046, respectively]). For subjects receiving NIV with a do-not-intubate order, success and in-hospital mortality rates were similar in different age groups (P = .27 and P = .98, respectively).CONCLUSIONS: NIV use and a do-not-intubate status are more frequent in subjects with ARF ≥65 y than in those <65 y, especially for subjects with cardiogenic pulmonary edema. However, NIV success and mortality rates were similar between age groups. (ClinicalTrials.gov registration NCT00458926.)