PT - JOURNAL ARTICLE AU - Patrícia Leão da Silva AU - Marco Túlio de Mello AU - Nadia Carla Cheik AU - Priscila Lima Sanches AU - Aline de Piano AU - Flávia Campos Corgosinho AU - Raquel Munhoz da Silveira Campos AU - June Carnier AU - Daniela Inoue AU - Claudia MO do Nascimento AU - Lila M Oyama AU - Lian Tock AU - Sérgio Tufik AU - Ana R Dâmaso TI - The Role of Pro-inflammatory and Anti-inflammatory Adipokines on Exercise-Induced Bronchospasm in Obese Adolescents Undergoing Treatment AID - 10.4187/respcare.01307 DP - 2012 Apr 01 TA - Respiratory Care PG - 572--582 VI - 57 IP - 4 4099 - http://rc.rcjournal.com/content/57/4/572.short 4100 - http://rc.rcjournal.com/content/57/4/572.full AB - BACKGROUND: Recent studies have demonstrated a greater prevalence in exercise-induced bronchospasm (EIB) in obese adolescents. However, the role of pro-/anti-inflammatory adipokines and the repercussions of obesity treatment on EIB need to be explored further. Therefore, the objective of this study was to evaluate the role of pro-/anti-inflammatory adipokines on EIB in obese adolescents evaluated after long-term interdisciplinary therapy. METHODS: Thirty-five post-pubertal obese adolescents, including 20 non-EIB (body mass index [BMI] 36 ± 5 kg/m2) and 15 EIB (BMI 36 ± 5 kg/m2), were enrolled in this study. Body composition was measured by plethysmography, using the BOD POD body composition system, and visceral fat was analyzed by ultrasound. Serum levels of adiponectin and leptin were analyzed. EIB and lung function were evaluated according to the American Thoracic Society criteria. Patients were recruited to a 1-year interdisciplinary intervention of weight loss, consisting of medical, nutritional, exercise, and psychological components. RESULTS: Anthropometrics and lung function variables improved significantly after the therapy in both groups. Furthermore we observed a reduction in EIB occurrence in obese adolescents after treatment. There was an increase in adiponectin levels and a reduction in leptin levels after the therapy. In addition, a low FEV1 value was a risk factor associated with EIB occurrence at baseline, and was correlated after treatment with changes in anthropometric and maximal O2 consumption values as well as the adipokines profile. CONCLUSIONS: In the present study it was demonstrated that 1 year of interdisciplinary therapy decreased EIB frequency in obese adolescents, paralleled by an increase in lung function and improvement in pro-/anti-inflammatory adipokines.