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Vasoactive Intestinal Polypeptide as Mediator of Asthma

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Abstract

Vasoactive intestinal polypeptide (VIP) is one of the most abundant, biologically active peptides found in the human lung. VIP is a likely neurotransmitter or neuromodulator of the inhibitory non-adrenergic non-cholinergic airway nervous system and influences many aspects of pulmonary biology. In human airways VIP-immunoreactive nerve fibres are present in the tracheobronchial airway smooth muscle layer, the walls of pulmonary and bronchial vessels and around submucosal glands. Next to its prominent bronchodilatory effects, VIP potently relaxes pulmonary vessels. The precise role of VIP in the pathogenesis of asthma is still uncertain. Although a therapy using the strong bronchodilatory effects of VIP would offer potential benefits, the rapid inactivation of the peptide by airway peptidases has prevented effective VIP-based drugs so far and non-peptide VIP-agonists did not reach clinical use.

References (159)

  • EM Lutz et al.

    The VIP2 receptor: molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide

    FEBS Lett

    (1993)
  • E Ciccarelli et al.

    Properties of the VIP-PACAP type II receptor stably expressed in CHO cells

    Regul Pept

    (1994)
  • A Couvineau et al.

    Human intestinal VIP receptor: cloning and functional expression of two cDNA encoding proteins with different N-terminal domains

    Biochem Biophys Res Commun

    (1994)
  • A Couvineau et al.

    Vasoactive intestinal peptide (VIP)1 receptor. Three nonadjacent amino acids are responsible for species selectivity with respect to recognition of peptide histidine isoleucineamide

    J Biol Chem

    (1996)
  • SP Sreedharan et al.

    Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor

    Biochem Biophys Res Commun

    (1993)
  • P Gourlet et al.

    Development of high affinity selective VIP1 receptor agonists

    Peptides

    (1997)
  • P Gourlet et al.

    In vitro properties of a high affinity selective antagonist of the VIP1 receptor

    Peptides

    (1997)
  • L Pei

    Molecular cloning of a novel transcriptional repressor protein of the rat type 1 vasoactive intestinal peptide receptor gene

    J Biol Chem

    (1998)
  • M Delgado et al.

    Differential expression of vasoactive intestinal peptide receptors 1 and 2 (VIP-R1 and VIP-R2) mRNA in murine lymphocytes

    J Neuroimmunol

    (1996)
  • M Svoboda et al.

    Molecular cloning and functional characterization of a human VIP receptor from SUP-T1 lymphoblasts

    Biochem Biophys Res Commun

    (1994)
  • P Gourlet et al.

    The long-acting vasoactive intestinal polypeptide agonist RO 25-1553 is highly selective of the VIP2 receptor subclass

    Peptides

    (1997)
  • DA Groneberg et al.

    Expression and distribution of vasoactive intestinal polypeptide receptor VPAC2 mRNA in human airways

    Lab Invest

    (2001)
  • T Sata et al.

    Vasoactive intestinal peptide evokes endothelium-dependent relaxation and cyclic AMP accumulation in rat aorta

    Peptides

    (1988)
  • SM Shreeve et al.

    Molecular properties of the vasoactive intestinal peptide receptor in aorta and other tissues

    Peptides

    (1992)
  • SC Martin et al.

    Vasoactive intestinal peptide stimulates a cAMP-mediated Cl- current in avian salt gland cells

    Regul Pept

    (1994)
  • S Audigier et al.

    Vasoactive intestinal polypeptide increases inositol phospholipid breakdown in the rat superior cervical ganglion

    Brain Res

    (1986)
  • RK Malhotra et al.

    Vasoactive intestinal polypeptide and muscarine mobilize intracellular Ca2+ through breakdown of phosphoinositides to induce catecholamine secretion. Role of IP3 in exocytosis

    J Biol Chem

    (1988)
  • D Stallwood et al.

    Identity of a membrane-bound vasoactive intestinal peptide-binding protein with calmodulin

    J Biol Chem

    (1992)
  • M Andersson et al.

    Simultaneous solubilization of high-affinity receptors for VIP and glucagon and of a low-affinity binding protein for VIP, shown to be identical to calmodulin

    FEBS Lett

    (1993)
  • SI Said

    Vasoactive intestinal peptide: involvement of calmodulin and catalytic antibodies

    Neurochem Int

    (1993)
  • JD Boomsma et al.

    The role of neuropeptides in asthma

    Chest

    (1992)
  • JM Hand et al.

    Relaxation of isolated guinea pig trachea, bronchi and pulmonary arteries produced by vasoactive intestinal peptide (VIP)

    Eur J Pharmacol

    (1984)
  • RJ Altiere et al.

    Comparative effects of inhaled isoproterenol and vasoactive intestinal peptide on histamine-induced bronchoconstriction in human subjects

    Chest

    (1984)
  • A Morice et al.

    Vasoactive intestinal peptide causes bronchodilatation and protects against histamine-induced bronchoconstriction in asthmatic subjects

    Lancet

    (1983)
  • O Ito et al.

    Vasoactive intestinal polypeptide precursors have highly potent bronchodilatory activity

    Peptides

    (1991)
  • SI Said et al.

    Polypeptide with broad biological activity: isolation from small intestine

    Science

    (1970)
  • SI Said et al.

    Potent peripheral and splanchnic vasodilator peptide from normal gut

    Nature

    (1970)
  • MA Ghatei et al.

    Regulatory peptides in the mammalian respiratory tract

    Endocrinology

    (1982)
  • JN Baraniuk et al.

    Vasoactive intestinal peptide in human nasal mucosa

    J Clin Invest

    (1990)
  • CJ Woodhead

    Neuropeptides in nasal mucosa

    Clin Otolaryngol

    (1994)
  • SI Said

    Vasoactive peptides in the lung, with special reference to vasoactive intestinal peptide

    Exp Lung Res

    (1982)
  • RD Dey et al.

    Localization of VIP-immunoreactive nerves in airways and pulmonary vessels of dogs, cat, and human subjects

    Cell Tissue Res

    (1981)
  • A Laitinen et al.

    VIP like immunoreactive nerves in human respiratory tract. Light and electron microscopic study

    Histochemistry

    (1985)
  • A Luts et al.

    Peptide-containing nerve fibers in the respiratory tract of the ferret

    Cell Tissue Res

    (1989)
  • A Fischer et al.

    Nitric oxide synthase in neurons and nerve fibers of lower airways and in vagal sensory ganglia of man. Correlation with neuropeptides

    Am J Respir Crit Care Med

    (1996)
  • A Fischer et al.

    Evidence for an esophageal origin of VIP-IR and NO synthase-IR nerves innervating the guinea pig trachealis: a retrograde neuronal tracing and immunohistochemical analysis

    J Comp Neurol

    (1998)
  • A Fischer et al.

    Correlation of vasoactive intestinal peptide and nitric oxide synthase with choline acetyltransferase in the airway innervation

    Ann N Y Acad Sci

    (1996)
  • E Cutz et al.

    Release of vasoactive intestinal polypeptide in mast cells by histamine liberators

    Nature

    (1978)
  • MS O»Dorisio et al.

    Vasoactive intestinal polypeptide modulation of lymphocyte adenylate cyclase

    J Immunol

    (1981)
  • RFFR Murphy et al.

    Immunoreactivities of vasoactive intestinal peptide (VIP) and glucagon in leukocytes from leukaemic patients

    J Lab Clin Med

    (1981)
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    Author for correspondence: David A. Groneberg, Division of Allergy Research, Department of Pediatric Pneumology and Immunology, Biomedical Research Center, Forum 4, Charité Campus-Virchow, Ausgustenburger Platz 1, 13353 Berlin, Germany. Fax: +49-30450559951.E-mail: [email protected]

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