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Reference values for volumetric capnography-derived non-invasive parameters in healthy individuals

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Abstract

The aim of this study was to determine typical values for non-invasive volumetric capnography (VCap) parameters for healthy volunteers and anesthetized individuals. VCap was obtained by a capnograph connected to the airway opening. We prospectively studied 33 healthy volunteers 32 ± 6 years of age weighing 70 ± 13 kg at a height of 171 ± 11 cm in the supine position. Data from these volunteers were compared with a cohort of similar healthy anesthetized patients ventilated with the following settings: tidal volume (VT) of 6–8 mL/kg, respiratory rate 10-15 bpm, PEEP of 5–6 cmH2O and FiO2 of 0.5. Volunteers showed better clearance of CO2 compared to anesthetized patients as indicated by (median and interquartile range): (1) an increased elimination of CO2 per mL of VT of 0.028 (0.005) in volunteers versus 0.023 (0.003) in anesthetized patients, p < 0.05; (2) a lower normalized slope of phase III of 0.26 (0.17) in volunteers versus 0.39 (0.38) in anesthetized patients, p < 0.05; and (3) a lower Bohr dead space ratio of 0.23 (0.05) in volunteers versus 0.28 (0.05) in anesthetized patients, p < 0.05. This study presents reference values for non-invasive volumetric capnography-derived parameters in healthy individuals. Mechanical ventilation and anesthesia altered these values significantly.

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Authors and Affiliations

  1. Department of Anesthesiology, Hospital Privado de Comunidad, Mar del Plata, Argentina

    Gerardo Tusman, Agustin Torroba & Federico Casella

  2. Department of Critical Care Medicine, Hospital Italiano, Buenos Aires, Argentina

    Emiliano Gogniat, Sergio Giannasi & Eduardo San Roman

  3. Swisstom AG, Landquart, Switzerland

    Stephan H. Bohm

  4. Bioengineering Laboratory, Electronic Department, School of Engineering, Mar del Plata University, Mar del Plata, Argentina

    Adriana Scandurra

  5. Department of Surgical Sciences, Clinical Physiology University Hospital, Uppsala, Sweden

    Fernando Suarez-Sipmann

  6. Instituto de investigación Sanitaria. Fundación Jiménez Díaz. IIS-FJD, CIBERES, Madrid, Spain

    Fernando Suarez-Sipmann

Authors
  1. Gerardo Tusman
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  2. Emiliano Gogniat
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  3. Stephan H. Bohm
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  4. Adriana Scandurra
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  5. Fernando Suarez-Sipmann
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  6. Agustin Torroba
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  7. Federico Casella
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  8. Sergio Giannasi
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  9. Eduardo San Roman
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Corresponding author

Correspondence to Gerardo Tusman.

Additional information

This work was performed at Hospital Privado de Comunidad, Mar del Plata, Argentina and Hospital Italiano, Buenos Aires, Argentina.

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Tusman, G., Gogniat, E., Bohm, S.H. et al. Reference values for volumetric capnography-derived non-invasive parameters in healthy individuals. J Clin Monit Comput 27, 281–288 (2013). https://doi.org/10.1007/s10877-013-9433-x

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  • DOI: https://doi.org/10.1007/s10877-013-9433-x

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