Differential effects of milrinone and dobutamine on right ventricular preload, afterload and systolic performance in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy☆
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2022, American Journal of Emergency MedicineCitation Excerpt :However, dobutamine has a half-life of 2 min compared to the half-life of milrinone which is 2–4 h [67]. While direct comparisons of these medications specifically for RHF are sparse, the limited evidence on RHF and trials in patients with advanced decompensated heart failure in general show similar clinical outcomes with either medication [69-71]. Given the shorter half-life, lower cost, and ED availability, dobutamine may be a preferable choice for use in the ED.
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2021, Clinics in Chest MedicineCitation Excerpt :Dobutamine improves hemodynamics in severe RV infarction and in PH after liver transplantation.37,56 Milrinone, a selective PDE-3 inhibitor, often is used in pulmonary vascular dysfunction due to LV dysfunction or post–cardiac transplant, because it reduces PA pressures and improves RV function.57,58 Its use in PAH or isolated RV failure can be limited by systemic hypotension or its effects on an unloaded LV.
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This work was performed when Dr. Eichhorn and Dr. Weiland were recipients of fellowship awards from the American Heart Association, Massachusetts Affiliate.