Clinical studyHyperuricemia in acute illness: a poor prognostic sign☆
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Hyperuricemia in acute heart failure. More than a simple spectator?
2009, European Journal of Internal MedicineCitation Excerpt :In a study in 119 consecutive patients with mild CHF, defined as a NYHA class of I–III, elevated serum levels, UA were strongly and independently associated with poor outcome correlated with high sensitive C-reactive protein levels and predicted intolerance to exercise [11]. In an early study performed in a small population, UA serum levels first appeared to have prognostic values in acute illnesses [25]. As recently reported by Cengel et al. 85 patients admitted with decompensate heart failure in NYHA functional class IV, serum UA levels and female gender were the only predictors of in-hospital mortality [26].
Uric Acid as a Prognostic Factor for Survival Time: A Prospective Cohort Study of Terminally Ill Cancer Patients
2006, Journal of Pain and Symptom ManagementCitation Excerpt :The danger signal, according to the report, facilitates the differentiation of CD8+ T cells and reinforces the reaction of the immune system against the damaged cells. Woolliscroft et al.22 reported that hyperuricemia reflected a severe level of hypoxia of the tissues as well as the increasing destruction of adenosine triphosphate (ATP). Decreasing renal function is a well-known risk factor for hyperuricemia.
Uric acid in chronic heart failure
2005, Seminars in NephrologyMulti-omics integration reveals a nonlinear signature that precedes progression of lung fibrosis
2024, Clinical and Translational ImmunologySERUM BIOMARKERS FOR PULMONARY HYPERTENSION
2022, Bulgarian Cardiology
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This work was supported by USPHS grant AM 19674 and 5M01 RR42.
- 1
From the Human Purine Research Center, Department of Internal Medicine and Biological Chemistry, University of Michigan, Ann Arbor, Michigan.