Extracorporeal oxygenation with hydrogen peroxide: A preliminary report

doi:10.1016/0022-4804(69)90123-1

Journal of Surgical Research

Volume 9, Issue 8, August 1969, Pages 487-491

https://doi.org/10.1016/0022-4804(69)90123-1 Get rights and content

Abstract

A method for increasing the oxygenating efficiency of membranes has been described. It consists mainly in the addition of hydrogen peroxide to the dialyzing fluid of an artificial kidney unit. The pH, pO₂, pCO₂, plasma hemoglobin, blood flow, and arterial and venous pressures have been measured during 6 hours of perfusion.

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There are more references available in the full text version of this article.

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Safety and Efficacy of Hydrogen Peroxide in Controlling Blood Loss and Surgical Site Infection After Multisegmental Lumbar Spine Surgery: A Retrospective, Case-Controlled Study
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In otorhinolaryngeal surgery, H2O2 irrigation can be effectively used during adenoidectomy for reducing intraoperative blood loss and the cost of surgery.16 The hemostatic effect of H2O2 results from the oxidation reaction and thermal effects, which promote platelet aggregation and act on the vascular endothelial cells to cause coagulation and shrinkage and degeneration of the capillaries.19-21 Because we used H2O2 irrigation before incision closure, only the postoperative blood loss could be controlled, not the intraoperative blood loss.
To explore the safety and efficacy of hydrogen peroxide H₂O₂ in controlling blood loss and surgical site infection (SSI) after multisegmental lumbar spine surgery.
A total of 2626 patients who had undergone multisegmental lumbar spinal surgery from January 2015 to January 2018 were included in the present study. Stratified by the use of H₂O₂ irrigation, they were divided into 2 groups: the control group (n = 1345) and the experimental group (n = 1281). The demographic parameters, laboratory examination results, and surgery-related information (e.g., operative time, number of operated levels, intraoperative blood loss, postoperative drainage, postoperative SSI, extubation time), and perioperative complications were recorded.
No significant differences were seen regarding the demographic parameters, laboratory examination results, comorbidities, and surgery-related information. The extubation time and postoperative drainage collection were lower in the experimental group (3.6 ± 0.5 vs. 4.1 ± 0.6 days, P = 0.402; 251.8 ± 67.5 vs. 291.8 ± 71.3 mL, P = 0.013). In the control group, the rate of SSI was 2.4% (32 of 1345) and included 17 superficial wound infections and 15 deep wound infections. In the experimental group, the SSI rate was 1.4% (18 of 1281; 15 with a superficial wound infection and 3 with a deep wound infection). Staphylococcus aureus was the most common organism, especially in the experimental group (66.7% vs. 50%). No statistically significant difference was found between the 2 groups in the perioperative complications, including hematencephalon, deep vein thrombosis, pulmonary embolism, and myocardial infarction (P > 0.05). Pneumocephalus was not observed in either group.
The application of H₂O₂ in posterior lumbar interbody fusion can reduce the blood loss and incidence of SSI after surgery and was quite beneficial for controlling the increasing number of vancomycin-resistant bacteria.
Pulmonary support by intravenous oxygenation through capillary silicone rubber tubing
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1996, ASAIO Journal

^☆: This study was supported by the Medical Research Council of Canada Grants No. MA-2865 and ME-2866.

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Extracorporeal oxygenation with hydrogen peroxide: A preliminary report☆

Abstract

J. Thorac. Cardiov. Surg.

Brit. J. Anaesth.

Heart-Lung Bypass Principles and Techniques of Extracorporeal Circulation